Senior Associate Director role at Alzheimer’s Association leading scientific grants, peer review and clinical trial pipeline tracking in dementia research. www.dementiaresearcher.nihr.ac.uk/job/senior-a...

Senior Associate Director: Scientific Grants

Alzheimer’s Association seeks a Senior Associate Director to lead scientific grants, peer review and clinical trial pipeline tracking in dementia research.

dementiaresearcher.nihr.ac.uk

60 centiloids. Fascinating. www.alzforum.org/news/confere...

My grant that I submitted in October finally got assigned to a study section scheduled for May 21. Quite the system we've got going here.

Gotta love a story about a nice Jewish boy listening to the advice of his mother. www.science.org/content/arti...

Meet three scientists who said no to Epstein

The warning signs included a web search, a mother’s doubts, and inklings of a “sexist attitude”

science.org

This is a very carefully worded way of saying that all funding decisions are coming from top from here on out. Also, no more paylines. grants.nih.gov/news-events/...

I sure would like to have time to focus on completing and writing up the actual science. What a silly system we’ve got.

Why on earth would zoom’s default setting be to allow meeting attendees to annotate your shared screen? I gave a public seminar yesterday, and one of the attendees started drawing red lines on the presentation slides 🤦🏻‍♂️. I didn’t even know that was possible.

Bravo. This MIGHT be why. I wish every science joirnalism article framed it this way. theconversation.com/people-who-s...

People who survive cancers are less likely to develop Alzheimer’s – this might be why

A new mouse study suggests some cancers release signals that help the brain clear Alzheimer’s-linked proteins, offering clues to a long-standing medical mystery.

theconversation.com

This quantification of loss is staggering. And knowing some of the excellent people that make up these numbers… is heartbreaking www.science.org/content/arti...

U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office

A Science analysis reveals how many were fired, retired, or quit across 14 agencies

science.org

It looks like another government shutdown might be incoming. Which means more study section and council delays, and more scientists holding on by an ever thinning string. But you won’t see many scientists complaining, because I assume most of us agree that Congress needs to try and restrain ICE.

Fully funded PhD programme at Kings College London training researchers to use human genetics AI and multi omics for therapeutic target discovery. Closing date: 28th February www.dementiaresearcher.nihr.ac.uk/job/phd-geno...

PhD: Genome Data Science - DEMENTIA RESEARCHER

Kings College London offers fully funded PhDs using genome data science and AI to discover therapeutic targets for disease.

dementiaresearcher.nihr.ac.uk

This study makes my head hurt. Can a gene variant that’s present in 95% of human beings (APOE3) be considered a risk allele? www.ucl.ac.uk/news/2026/ja...

Most Alzheimer’s cases linked to variants in a single gene

Potentially more than 90% of Alzheimer’s disease cases would not occur without the contribution of a single gene (APOE), according to a new analysis led by UCL researchers.

ucl.ac.uk

Apparently 2025 was a big year for APOE4 publications

A powerful maiden speech by my senator, whose dad was recently diagnosed with Alzheimer’s disease. newjerseyglobe.com/congress/in-...

In maiden Senate speech, Andy Kim promises to care for his father and for America - New Jersey Globe

Exactly one year after he was first sworn in as a U.S. Senator, Andy Kim gave his maiden speech on the Senate floor today. The speech, technically Kim’s

newjerseyglobe.com

My lab member @arainhirra.bsky.social was saying that she thinks journals should pay scientists to publish their research. I hadn’t really thought about it, but now that I do…why haven’t there been smaller journals that have tried to leapfrog the larger journals by offering to buy high impact work?

APOE-directed therapeutics in AD: My first substack post: open.substack.com/pub/hyassine...

ApoE directed Therapeutics in Alzheimer's disease, SFN 2025

Alzheimer’s disease has historically been viewed through the lens of amyloid plaques and tau tangles, but accumulating evidence shows that these features alone cannot fully explain why some individual...

open.substack.com

Currently watching Pluribus, and they’ve got their rats in mouse cages. Someone call IACUC.

www.nature.com/articles/d41...

Three rising stars in ageing research

From Alzheimer’s to obesity, these researchers are tackling the most common age-related conditions.

nature.com

Love this story (although the headline’s a little misleading). apple.news/A5noSQhLDRdu...

6-year-old girl comes to the rescue of Harvard researchers studying the axolotl — CBS News

Earlier this year, a Harvard research team studying the axolotl, a salamander with the superpower to regrow body parts, lost almost all its government funding.

apple.news

I feel slightly less guilty about using AI to help me write a grant about an AI-based project. But that might be how the machines want me to feel.

While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from @bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...

Sex-specific factors and APOEε4 genotype alter functional connectivity at middle age

Cognitive aging is influenced by sex and sex-specific factors. Indeed, research has shown that parity (pregnancy and parenthood) uniquely alters bioma…

sciencedirect.com

Love it! Now I want to carve a pumpkin as a mouse brain, but I think it's too late.

Marco A. Maximo Prado@maximoprado.bsky.social · 11mo ago

and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz

In the mood for something sciency and spooky? How about the Halloween special of @uclbrainstories.bsky.social - where me and @caswell.bsky.social talk to @drjlange.bsky.social on some of the gothic stories in neuroscience! 👻 🧠 🎃 💀🧟‍♂️ spotify.link/2lHT9pLQRXb

Episode 23- Jenny Lange on the gothic history of neuroscience, a Halloween special

spotify.link

Don't worry folks! Pretty soon we'll go from having a 0% chance of getting grants (govt shutdown) to having a 5% chance of getting grants (continuing resolution and multi-year funding). But that's only temporary...eventually, it'll go back to the easy-peasy 10-15% funding lines we all know and love.

Very interesting

Molecular Neurodegeneration@molneurodegen.bsky.social · 11mo ago

'Interplay between #astrocyte reactivity and #APOE ε4 status is associated with accelerated #pTau-related tau pathology in #AlzheimersDisease' Xiaoxie Mao, Yan Wang, Ying Luan, Ying Wang...Binyin Li, Zijing Li, Qihao Guo, Fang Xie molecularneurodegeneration.biomedcentral.com/articles/10....

That's a hell of a figure. www.alzforum.org/news/researc...

Hmm. Reading about oxygen administration for preterm babies and the potential for hyperoxia and oxidative stress, and that is a topic that I’ve heard zero info about up until now.

Pushing through my skepticism to review these K99 and K01 applications I've been assigned. The good news is that there are some tremendous applicants that could contribute so much if given the chance. The bad news is that there's no way to give them a chance if the govt doesn't open back up.

Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects. pubs.acs.org/doi/abs/10.1...

Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics

Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...

pubs.acs.org

Is it sad that my first thought was: a five year cell culture experiment isn't that bad. There would still be two years left to finish up their PhD or postdoc 😭 😭https://www.alzforum.org/news/research-news/neurons-born-and-raised-organoids-act-their-age