Taru Muranen lab
@tarumur.bsky.social
We study tumor stroma interactions in my lab at BIDMC at Boston, and are big fans of fibroblasts and ECM. Opinions are my own!
And it is finally officially out and about.
Nature Cell Biology@natcellbio.nature.com · 4mo ago☕ @tarumur.bsky.social , @nina-kozlova.bsky.social & co report a functional role for NDRG1 in regulating R-loops & DNA repair, thus linking cancer-associated fibroblast-derived extracellular matrix to chemotherapy responses in pancreatic cancer. #PDAC @bidmc-cancercenter.bsky.social bit.ly/4dwcz0W
5. Another @natcellbio.nature.com paper, this time from senior author @tarumur.bsky.social, reporting on the identification of a novel role for cancer-associated fibroblasts in pancreatic ductal adenocarcinomas. Dr. Muranen is one of six ACS grantee authors on the paper. doi.org/10.1038/s415...
Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing - Nature Cell Biology
Kozlova et al. report a functional role for NDRG1 in regulating R-loops and DNA repair, thereby linking cancer-associated fibroblast-derived extracellular matrix to chemotherapy responses in pancreati...
doi.org
Our project of ten years is finally out today @natcellbio.nature.com. Huge thanks for the tour de force to first author @nina-kozlova.bsky.social and all the co-authors, collaborators, and of course the whole Muranen lab. rdcu.be/ffBUb
Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing
Nature Cell Biology - Kozlova et al. report a functional role for NDRG1 in regulating R-loops and DNA repair, thereby linking cancer-associated fibroblast-derived extracellular matrix to...
rdcu.be
Happy to post this online-first article published in @aacrjournals.bsky.social Molecular Cancer Research by the talented (and recently graduated!) Dr. Hanna Doh @hannadoh.bsky.social ! aacrjournals.org/mcr/article/...
Interaction of NDRG1 and TGM2 modulates DNA replication and repair
Abstract. In tumor cells, DNA replication is constantly challenged by endogenous and exogenous sources, referred to as replication stress, and various pathways have evolved to mitigate this stress in ...
aacrjournals.org
Happy to celebrate #WomenInScience and @kaylacruzer.bsky.social in particular who defended her PhD beautifully yesterday from #Harvard BBS program! Amazing job and packed room too!!!
Such an amazing day yesterday, my first student defended her PhD thesis beautifully. Congratulations Dr. Hanna Doh @hannadoh.bsky.social !!!
This is pretty cool...
Eric Topol@erictopol.bsky.social · 11mo agoWhy does the naked mole rat have the longest lifespan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation www.science.org/doi/10.1126/...
Oh the irony... The lead pic from a lab and the whole institution they just gave stop work orders.. though I do love organoids so yay for that... www.nih.gov/news-events/...
NIH to prioritize human-based research technologies
New initiative aims to reduce use of animals in NIH-funded research.
nih.gov
So so happy for you, especially in these times of frequent gloom, this is such great news, makes me very happy! Go Violet!
Violet Hong 수민@violet-hong.bsky.social · last yr.Im beyond thrilled to share that I will be attending Vanderbilt IGP PhD program this fall! I want to sincerely thank @tarumur.bsky.social and @klab.bsky.social being amazing scientific beacons for the past 4 years! I hope to continue my passion in researching GI diseases at Vandy! Go dores! 💛
Please please colleagues in other states, write to your representatives, the link is below through AACR.
Ludwig Cancer Research@ludwigcancer.bsky.social · 2y agoWorried about continued funding for cancer (and other biomedical) research? @theaacr.bsky.social will help you reach your representatives in the U.S. Congress. bit.ly/4inD1eb
We (me and lab) will be showing up in Boston, come join tomorrow Friday at Boston Common 12pm if you care about the future of science and in our case cancer research!!!
Stand Up for Science!@standupforscience.net · 2y agoSO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING! To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
chng.it
There are legit criticisms of IDCs and how they are negotiated, but cutting infrastructural and administrative support to 1/4-1/6 of what it was overnight is a devastating assault on universities and US biomedical research.
Needhi Bhalla 💅🏽@needhibhalla.bsky.social · 2y agowhat a fucking Friday afternoon news dump: they are capping indirects at 15% grants.nih.gov/grants/guide...
An Optimized Protocol for Simultaneous Propagation of Patient-derived Organoids and Matching CAFs Work by Jenny Högström (@jennyhogstrom.bsky.social) and Taru Muranen (@tarumur.bsky.social) at Beth Israel Deaconess Medical Center. #LifeSciences #Reproducibility #CancerBiology
Happy holidays from our labs to yours, and we were happily surprised by the snow as well (and the gigantic snow men at HMS)!!!
Our VERY detailed protocol of generating HR+ breast cancer organoids and matching CAFs is out: bio-protocol.org/e5160 This is a follow-up to @jennyhogstrom.bsky.social last paper, just with more details to help everyone generate these organoid CAF co-cultured and to move cancer research forward!
bio-protocol.org
First post ever here, to celebrate my amazing lab and their recent achievements!
