the most realistic scene in Jurassic Park is when two scientists make a questionable decision — traveling to an undisclosed location with a strange man — on the promise of three years of modest funding
Nicholas Tatonetti, PhD
@tatonetti.bsky.social
Making drugs safer one billion data points at a time. @CedarsSinai Prof, @Stanford BMI, @Columbia DBMI, EiC of BioData Mining, he/they enby 🏳️🌈
I wrote about the history, politics, and persistence of giving babies their fathers' last names. And in doing this research, I've concluded that all last names are bad actually!
Why Is Dad's Name Still the Default?
the history, politics, and law of patrilineal naming
aubreyhirsch.substack.com
It's time again for the AMIA Translational Bioinformatics Year-in-Review! This year: 2k papers triaged, 600+ reviewed. The final set is wild. Foundation models, multimodal bio, spatial everything, generative proteins, and some pure brain candy. Can't wait to present! #Amplify2026
OnSIDES v3.1.1 is out! 🎉 Updated with drug labels through April 2026 from all four sources (US, UK, EU, Japan): - 41K+ product labels - 6.9M drug–adverse event pairs - 4,097 ingredients Also fixes some bugs — if you're using that., please upgrade. github.com/tatonetti-la...
Release OnSIDES v3.1.1 · tatonetti-lab/onsides
Updated April 2026 with the latest drug labels from all four regulatory sources. Summary Type v3.1.0 v3.1.1 Products 42,268 41,119 Adverse effects 5,472,613* 6,928,666 Ingredients 1,955 ...
github.com
GI fellow Jamil Samaan noticed something odd when using AI ambient scribes and speech transcription tools Clinicians with non-native English accents appeared to confuse the model He and Yassi Fatapour decided to investigate, now out in npj Digital Medicine www.nature.com/articles/s41...
Accent related errors in clinical speech transcription and a LLM-based remedy - npj Digital Medicine
npj Digital Medicine - Accent related errors in clinical speech transcription and a LLM-based remedy
nature.com
New editorial in BioData Mining: A crisis of overconfidence in clinical AI led by @cedarssinaihsu.bsky.social PhD student, Jacob Berkowitz. Why sounding confident can be more dangerous than being inaccurate, and why calibration needs to be central in clinical AI. link.springer.com/article/10.1...
A crisis of overconfidence: Why confidence, not accuracy, is the real risk in clinical AI - BioData Mining
BioData Mining - Language models today are trained to convey confidence in their outputs, regardless of whether those outputs are correct. The alignment methods we use to make them helpful also...
link.springer.com
You can now connect ChatGPT to an Apple Watch. So I imported 29 mil steps & 6 mil heartbeats into the new ChatGPT Health. It graded my heart health an F. ⁉️ Cardiologist @erictopol.bsky.social called it “baseless.” Any bot claiming to give health insights shouldn’t be this clueless. Even in beta. 🧵
I suspect Holly Mitchell is going to find in the coming years that she shares Henry Waxman's legacy as someone who blocked a whole part of the LA region from getting rail for decades due to needless, pointless capitulation to fearmongering. Her time on the Metro Board will not be remembered kindly.
Excited to announce our new project with ARPA-H which advances methods to artificially accelerate the aging of organoids to study drug toxicities over time!! A current huge gap in our understanding and our models. www.cedars-sinai.org/newsroom/ced...
Cedars-Sinai Will Pioneer AI in Drug Safety With New Funding
Cedars-Sinai receives an up to $5,054,235.00 award to develop KronosRx, a platform using AI and 'patient avatars' to predict adverse drug reactions, improve cli
cedars-sinai.org
Is "Agent Engineering" the next big thing? Getting so-called "AI Agents" to work together effectively isn't trivial. @moorejh.bsky.social and I discuss the need for rigorous development in our latest editorial in BioData Mining biodatamining.biomedcentral.com/articles/10....
From prompt engineering to agent engineering: expanding the AI toolbox with autonomous agentic AI collaborators for biomedical discovery - BioData Mining
biodatamining.biomedcentral.com
👀 Health AI PhD Information Session hosted by Cedars-Sinai! This event is an opportunity for interested students to learn more. November 21 @ 8 AM PT Register: forms.office.com/r/vMreBMZQak
Microsoft Forms
forms.office.com
Application period for the Cedars-Sinai PhD Program in Health AI is now OPEN! Come study cutting-edge AI in a top hospital with clinical rotations, clinical collaborators, & easy access to clinical data - please RP! www.cedars-sinai.edu/education/gr... #artificialintelligence #bioinformatics #phd
PhD in Health Artificial Intelligence
cedars-sinai.edu
Nice piece in the NYT about the risks of "magical thinking" with AI that allow big tech to hype their products www.nytimes.com/2025/09/25/o... #artificialintelligence #magic #hype #llms
Opinion | There’s Nothing Magical in the Machine
nytimes.com
Loving my state rn. California’s $23 Billion Plan to Restore Federal Cuts to Scientific Research www.nytimes.com/2025/09/13/u...
California’s $23 Billion Plan to Restore Federal Cuts to Scientific Research
nytimes.com
AI methods are great tools for advancing drug safety surveillance. We show that LLMs can accurately identify and extract essential concepts from messy product drug labels. Just published in _Drug Safety_! Great work led by @undinagislad! link.springer.com/article/10.1...
Leveraging Large Language Models in Extracting Drug Safety Information from Prescription Drug Labels - Drug Safety
Introduction Adverse drug reactions (ADRs), including those resulting from drug interactions, remain a leading cause of morbidity and mortality. Structured product labels (SPLs) serve as a primary sou...
link.springer.com
We used AI to audit 21,000+ RCTs. The result? -- only 15% of trials fully comply with CONSORT guidelines. Transparency in clinical trials has a long way to go. Amazing work by Apoorva in my group! jamanetwork.com/journals/jam...
An LLM Analysis of Reporting Quality of Randomized Clinical Trial Articles
This study uses a zero-shot large-language model to automatically assess compliance with the Consolidated Standards of Reporting Trials guideline for English-language randomized clinical trials publis...
jamanetwork.com
The top three science funders are the US, China, and Japan. The three fund more science than every other country, combined. In 2024, the US funded more scientific research than China and Japan, combined. The US also funds more science than every other country except for Japan and China, combined.
For the eleventy billionth time: Attacks on science funding and science jobs in the United States don’t mean that science will just move elsewhere. It means a lot less science for everyone. There aren’t enough jobs or funding everywhere else )combined) for US scientists to just move.
The 2025 volume of the Annual Review of Biomedical Data Science is now online. Take a look at the most read article from this new volume, "Spatial Transcriptomics Brings New Challenges and Opportunities for Trajectory Inference" arevie.ws/45D2NWD @marylynritchie.bsky.social @tatonetti.bsky.social
This creates a fun game that rewards superfluous, outlandish (dare I say outre?) verbiage.
Can Bluesky say every word in the dictionary? I dunno but I plan to find out! I made a website that tracks every single word said on bluesky (as of yesterday).
With the correct rhetorical device you can make complete jibberish sound like poetry. Just ask Shakespeare (or better read Forsyth's The Elements of Eloquence)
A new immigrant detention center will be opening in Indiana called the “Speedway Slammer,” modeled after Florida’s “Alligator Alcatraz.” On #playbookpod, Megan Messerly explains why the rhetoric used by the administration to describe these centers is significant. 🎧 Listen here: ow.ly/yY5B50WAzH8
Just came across this fail. Literally everything that's wrong with AI/tech in healthcare. Not only is the patient and doctor buried in their devices, but they're facing AWAY from each other 🤦♂️!! Technology should facilitate and center the humanity of healthcare. Not do whatever this is.
I’m petrified about today’s science news. Genetically modifying crabs to have cheetah genes? This could go sideways fast.
What is Vibe Coding and how can it be used to advance biomedical research? @tatonetti.bsky.social & I explain in this editorial biodatamining.biomedcentral.com/articles/10.... #bioinformatics #datascience #coding #vibecoding
Vibe coding: a new paradigm for biomedical software development - BioData Mining
biodatamining.biomedcentral.com
Vibe coding is coming for biomedical software development, my first editorial as Co-Editor-in-Chief of @BioDataMining with @moorejh.bsky.social biodatamining.biomedcentral.com/articles/10....
Vibe coding: a new paradigm for biomedical software development - BioData Mining
biodatamining.biomedcentral.com
If anyone is wondering, yes we will be monitoring the safety and side effects of drugs from the moment they hit the market
"At FDA we're accelerating drug approvals so that you don't need to use primates or even animal models. You can do the drug approvals very, very quickly with AI."
So the market for our drug safety monitoring algorithms just opened up 👀
"At FDA we're accelerating drug approvals so that you don't need to use primates or even animal models. You can do the drug approvals very, very quickly with AI."
Excited that our paper on GenAI-based text normalization is out at Journal of Biomedical Informatics! If you ever had a bunch of messy text and need to map it to a controlled terminology, then this is the method for you. www.sciencedirect.com/science/arti... Special 👏 to Jacob Berkowitz!!
Biomedical text normalization through generative modeling
A large proportion of electronic health record (EHR) data consists of unstructured medical language text. The formatting of this text is often flexibl…
sciencedirect.com
Learn observational data from the best. @ColumbiaDBMI and @OHDSI are offering summer school to learn all the real-world-data analysis tips and tricks. columbiauniversity1.regfox.com/ohdsi-summer...
TBD3
Online registration for Columbia OHDSI Summer School starts on April 9th 2025. Online registration ends July 11th 2025.
columbiauniversity1.regfox.com
✅ PASSED SENATE TRANSPORTATION COMMITTEE: SB 445 by @scottwiener.bsky.social that streamlines permit approval process for transit projects to tackle cities that cause costly delay against transit.