It is a deranged lie to say “there were ICUs… empty all over the country… at the height” of COVID. I was a medicine resident at Mass General in 2020. The hospital tripled its adult ICU capacity. Cancer units, peds ICUs, perioperative units all became COVID ICUs. They were full of dying patients.

Aaron Rupar@atrupar.com · 3d ago

RFK Jr: Trump wanted to end lockdowns. In Fauci's diary, he talks about how the president was calling him trying to get him to reopen the country BASH: The lockdowns were down by governors K: They cited Fauci B: Govs were hearing from hospitals that their ICUs were overrun K: That's not true

Ever write "consider" or "can" in your consult note recs? Retrospective study of 250 ID consults in Australia found primary team adherence to these "ambiguous" recommendations was 59.5%, while it was 87.2% for recommendations without such qualifiers academic.oup.com/cid/advance-...

Reconsidering ambiguous language in infectious disease consult recommendations

In this retrospective study of 1087 Infectious Diseases consultation recommendations at a multi-site health network in Australia, ambiguous language occurr

academic.oup.com

NIH grants have been under political scrutiny since early 2025. But what does the screening process actually look like? What is being flagged? I spent a month digging into leaked docs and emails. We've published the 235-word list that are being flagged by an internal AI tool. And so much more. 🧵

Inside the new political screening that’s stalling NIH grants

Mandatory reviews by top health officials and checks for 235 disfavoured terms have left hundreds of vetted grant applications in administrative limbo.

nature.com

The SNAP Trial Exemplifies What EBM Should Look Like: www.sensible-med.com/p/the-snap-t... #IDSky

The SNAP Trial Exemplifies What EBM Should Look Like

It's always worth showing properly designed and conducted trials--though it's bad for pageviews. Nonetheless, SNAP authors show the way to answering questions in biomedicine

sensible-med.com

Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

U.S. infectious disease research is on the brink. Without immediate action from Congress, much of it will cease to exist within a year. For example👇 1️⃣ No collaborative RFAs posted for >1 year (normal: many / year). 2️⃣ No foreign collaborators allowed on grants. 🧪🪦 www.idsociety.org/globalassets...

1/12 🎉 Our paper on colonization pressure (CP) and nosocomial pathogen acquisition is out in Nature Communications! Lots of surprising findings. www.nature.com/articles/s41...

Using electronic health records to assess the relationship between colonization pressure and nosocomial pathogen acquisition - Nature Communications

Hospitalised patients are at risk of acquiring infections, and the risk increases when there is a higher prevalence among ward co-occupants, known as colonisation pressure. Here, the authors built an ...

nature.com

🚨 My lab is hiring! @ucirvine.bsky.social Seeking full-time data scientists & machine learning engineers. We apply LLMs and AI tools to clinical data, rapidly scaling up epidemiological analyses and models of sepsis, hospital-acquired infections, and more. tpaklab.org #MedSky #IDsky 🧪 1/x

🚨 My lab is hiring! @ucirvine.bsky.social Seeking full-time data scientists & machine learning engineers. We apply LLMs and AI tools to clinical data, rapidly scaling up epidemiological analyses and models of sepsis, hospital-acquired infections, and more. tpaklab.org #MedSky #IDsky 🧪 1/x

ID fellow Alejandro De La Hoz Gomez, MD, of Mass General Brigham shares three things people don’t realize about a career in infectious diseases. #WhyILoveID

I'll try to TL;DR the debate lol (although its not a short TL;DR). ATS CAP guidelines say give antibiotics for CAP with +virus in severe CAP, non-severe hospitalized CAP, and outpatient CAP with comorbidities, but don't give antibiotics for non-comorbid outpatient CAP

I've been using #ClaudeCode for #research #informatics—cohort building, debugging pipelines, genomics in #AllofUs. Before any of that was useful, I had to set things up right. The setup isn't complicated, but it matters. Here's how I do it: 1/

The last part abt how measles disrupts immunity vs other infections is, imo, underappreciated (& mechanism was recently clarified). It's part of why measles vaccination was seen to help beyond just reducing measles complications - not getting measles reduces severity of subsequent infections too.

Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens

Measles virus infection can cause long-term damage to the immune system.

science.org

Ryan Marino, MD@ryanmarino.bsky.social · 5mo ago

Before the vaccine, 10% of measles infections resulted in deafness. Measles currently causes 100K children/yr to become blind. Even those who recover completely can later develop the fatal encephalitis. Every infection disrupts the immune system and can cause loss of all immunity to other infections

🚨 New pre-print! 🚨 In the largest study of its kind to-date, we investigate the ecological and evolutionary mechanisms driving within-patient evolution of antimicrobial resistance (AMR). Read here: www.biorxiv.org/content/10.6... , and follow along with this thread, discussing our findings (1/21)

Clinical trials affected by NIH grant terminations "Approximately 1 in 30 trials and more than 74 000 trial participants were affected ... Affected trials disproportionately studied infectious diseases, prevention, and behavioral interventions" #MedSky #IDSky jamanetwork.com/journals/jam...

Clinical Trials Affected by Research Grant Terminations at the National Institutes of Health

This cross-sectional study summarizes the number of trials with terminated grants from the National Institutes of Health (NIH) and calculates the proportion of affected trials among those with previou...

jamanetwork.com

What I'm Reading: Curiosity, a 1B-parameter model built on Epic Cosmos. It's genuinely interesting: zero-shot outputs rivaled supervised baselines across 78 real-world tasks, and the scaling laws (α=0.52) mirror NLP. Cool to see how information scales across domains. arxiv.org/abs/2508.12104 1/

Rise of anti-science rhetoric has fundamentally changed the relationship between doctors and patients www.statnews.com/2025/12/10/a... by @krutikakuppalli.bsky.social via @statnews.com #HHS #FDA #CDC #publichealth #vaccines #science #MedSky

Rise of anti-science rhetoric has fundamentally changed the relationship between doctors and patients

“The rise of anti-science and anti-vaccine rhetoric has fundamentally changed the relationship between clinicians and patients.”

statnews.com

A @idsainfo.bsky.social position statement in @cidjournal.bsky.social describing why the society backed out of ATS CAP guidelines. [In viral pneumonia] “briefly withholding antibiotics for patients with nonsevere illness to clarify the diagnosis is safe” #IDSky academic.oup.com/cid/advance-...

Infectious Diseases Society of America (IDSA) Position Statement: Why IDSA Did Not Endorse the Community-Acquired Pneumonia Guidelines 2025 Update

The Infectious Diseases Society of America (IDSA) did not endorse updated community-acquired pneumonia guidelines because they recommend antibiotics for pa

academic.oup.com

Today I am very proud to announce the release of the Antibiotic Resistance Microbiology Dataset - Mass General Brigham (ARMD-MGB; physionet.org/content/armd...) , as part of an NIH-funded collaboration led by Jonathan Chen at Stanford. (1/6)

To be effective, data science agents need to be able to read plots reliably. @sara-altman.bsky.social and I wrote about some concerning findings on LLMs' ability to interpret plots when the content contradicts their expectations on the @posit.co blog. posit.co/blog/introdu...

When plotting, LLMs see what they expect to see - Posit

Data science agents need to accurately read plots even when the content contradicts their expectations. Our testing shows today's LLMs still struggle here.

posit.co

Gave my 1st talk in NL: how to make multicenter data analysis with patient data actually work. tl;dr: common data models (global interoperability) + LLMs (data harmonization, mapping, future-proofing) + federated learning (privacy) Let me know what you think! drive.google.com/file/d/1N3yk...

An #LLM extracted signs and symptoms for patients with sepsis with similar accuracy to humans, and identified 7 syndromes differentially correlating with multidrug-resistant infection risk and mortality. ja.ma/47onWVE

Maybe AI Knows Something That We Do Not! 🆕💫 Cohort study LLM accurately extracted presenting signs & symptoms from admission notes that clustered into syndromes differentially correlated with infection sources, MDR infections, and mortality #IDsky jamanetwork.com/journals/jam...

Syndromic Analysis of Sepsis Cohorts Using Large Language Models

This cohort study compares the performance of a large language model against manual medical record review for extracting presenting signs and symptoms data from hospital admission notes and uses these...

jamanetwork.com

My new piece in @medpagetoday.com We Can Stop Deadly Hospital Outbreaks - So Why Aren't We? Genomic surveillance can prevent outbreaks from spreading, save lives, and costs. So what’s holding it back from being implemented in hospitals? #IDSky www.medpagetoday.com/opinion/seco...

Opinion | We Can Stop Deadly Hospital Outbreaks -- So Why Aren't We?

Genomic surveillance can help contain local and nationwide threats

medpagetoday.com

#IDsky #Medsky 🧪🦠

Sanjat Kanjilal@sanjatkanjilal.bsky.social · last yr.

It may be silly posting abt research in times like this but I have to share a small bit of joy with fellow ID heads. Our paper modeling the impact of colonization pressure on nosocomial pathogen acquisition just dropped on medRxiv! Only 3.5 years in the making. www.medrxiv.org/content/10.1... 1/14

New preprint from our lab by Rangachar Srinivasa et al: We WGS 4 major respiratory viruses in 3 hospitals (RSV, influenza, rhinovirus, HMPV) & found silent transmission happening under the radar Genomics uncovered hidden spread, complex transmission chains #IDSky 📄: www.medrxiv.org/content/10.1...

How many hospitalized patients need care in the ICU? How many of them survive? What interventions do they receive there? These are some of the questions I had two years ago while trying to write the "background" section for my masters thesis. But I couldn't find the answers... they did not exist.

JAMA@jama.com · last yr.

Following pandemic-era changes, many ICU outcome measures returned to prior levels. The rates of mechanical ventilation have declined even further, while vasopressor use remained elevated above 2010s rates. #MedSky https://ja.ma/42Jl3NO

The amount of green on this level of evidence guiding antifungal treatment duration demonstrates nicely the research knowledge gap in this field! #IDSky #ClinMicro #AMR @drneilstone.bsky.social

Simon B. Gressens@drsbg.bsky.social · last yr.

🍄 What determines the duration of antifungal therapy? 🦠💊 This comprehensive review explores the scientific foundations behind treatment duration, identifies key knowledge gaps, and highlights critical future directions in the field. Don’t miss it! 🔥 #IDSky www.sciencedirect.com/science/arti...

ondering how this year’s measles outbreaks compare to previous years? This chart shows that 2025 (dark purple) is already about 4x higher than this time last year (light purple), which was itself a sharp increase over 2023. The trend is alarming. Prevention—including vaccination—is critical.

ID - Return to Basics: This was the 1st reported case of an adult immunocompetent host who survived measles complicated by ARDS. A 36 yo female ED nurse, unvaccinated, who was exposed to a patient w active measles in October 1989. Ten days later, she developed measles