Our latest development:

Akul Mehta@akulmehta.bsky.social · 3w ago

Excited to share our new paper on our latest technology development: GlycoStrips Full paper open access: www.cell.com/trends/biote... #glycotime #glycobiology #pointofcare #diagnostics #immunemonitoring #immunity #antibodies #glycans

Check out fascinating insights on nature’s most abundant polymers in our latest blog post. 🌱 Cellulose 🦀 Chitin (found in insects & fungi) 💪 Hyaluronan 🍚 Starch 🦠 Peptidoglycan Read research.bidmc.org/ncfg/blog/27... #Glycobiology #Science #Biochemistry #Nature #CellBiology #Glycotime

The Glycomics Core at Beth Israel Deaconess Medical Center is looking for a Postdoctoral Research Fellow with LC-MS/MS proteomics/glycoproteomics experience. For more information check: research.bidmc.org/ncfg/careers... #proteomics #glycomics #glycoproteomics #lcms

In our latest Interesting Fact Post learn about Mitochondrial Glycoproteins! Think #mitochondria don't have #glycoproteins? Think again! New research shows O-GlcNAc modifications are key to: Energy Brain Health, Development Read: research.bidmc.org/ncfg/blog/25... #Glycobiology #glycotime

Fun collaboration with @thexavierlab.bsky.social and Ribbeck groups to figure out how this human lectin plays multiple roles in controlling the #microbiome: stabilizing the mucus barrier and reducing bacteria that breach it. news.mit.edu/2026/protein... #glycotime

A protein found in the GI tract can neutralize many bacteria

MIT researchers found that a protein called intelectin-2 has broad spectrum antimicrobial activity against bacteria found in the GI tract. Additionally, intelectin-2 can crosslink molecules that make ...

news.mit.edu

Amazing work–with potential therapeutic implications–by the @laurakiessling.bsky.social group reveals dual actions of interlectin-2 in stabilizing mucosal barriers and targeting bacteria that escape a compromised barrier www.nature.com/articles/s41...

Have you ever wondered how many N-Glycans or #glycoproteins there are on cells? The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell! Read the full blog post: research.bidmc.org/ncfg/blog/24... #glycobiology #glycotime #cells #biology

OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy www.federalregister.gov/documents/20...

Notice of Request for Information; Accelerating the American Scientific Enterprise

The Office of Science and Technology Policy (OSTP) requests input from all interested parties on Federal policy updates that aim to accelerate the American scientific enterprise, enable groundbreaking...

federalregister.gov

Have you heard of sugar alcohols / artificial sweeteners, such as erythritol, sorbitol, mannitol and xylitol? Learn more about these interesting small sugars and where they are found in our latest blog post, research.bidmc.org/ncfg/blog/23... #glycotime #glycosylation #science #artificialsweeteners

🤯 Did you know proteins inside cells can be glycosylated?! 🔬 Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in biology! 👉 research.bidmc.org/ncfg/blog/21... #glycans #glycosylation #posttranslationalmodification #glycotime

Exciting virtual seminar by Dr. Maxence Noel (From Dr. Richard Cummings' Lab) - "Brain N and O glycosylation: Discoveries, Tools and Dysregulation in Disease", held by the BGDG. Thursday July 17, 2025 at 12pm EDT. Register: docs.google.com/forms/d/e/1F... #glycotime #neuroglycobiology #neuroscience

📢New article alert! 'Blood group O expression in normal tissues and tumors', just published in FEBS Journal, highlights findings using our lamprey-derived monoclonal antibodies towards specific H antigen epitopes. Read at: febs.onlinelibrary.wiley.com/doi/10.1111/... #glycotime #glycans #bloodgroups

FEBS Press

The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4-31L and OmcFL3-...

febs.onlinelibrary.wiley.com

Antifreeze glycoproteins: not just for fish! 🤔 They could revolutionize food preservation and organ cryopreservation. Read more about this exciting potential in our latest interesting fact: research.bidmc.org/ncfg/blog/19... #glycotime #glycofacts #cryopreservation

Well, it turns out that you can actually make PyMOL do quite a lot of stuff. Here's the full workflow, integrating the amazing ReGlyco into PyMOL to re-glycosylate the LDLA linker. There's some serious magic needed to get it running as fast as it is within PyMOL. @elisafadda.bsky.social

Hiren Joshi@glyco.me · last yr.

"Your scientists were so preoccupied with whether or not they could that they didn't stop to think if they should" @elisafadda.bsky.social , you know we could make an awesome plugin.

By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date. Non-reduced native glycan analysis is key. We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

N-Glycopedia: Libraries for Native N-glycan Structural Analysis https://www.biorxiv.org/content/10.1101/2025.06.09.658590v1

Explosions, allergies, & more! 🤯 Polysaccharides are more surprising than you think! Read our latest interesting facts about Dangerous Carbohydrates: research.bidmc.org/ncfg/blog/18... #science #carbs #glycotime #glycofacts

Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy! www.nature.com/articles/s41...

Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology

An RNA-binding protein on leukemia cells provides an effective target in mouse models.

nature.com

📢 Our latest work describing a new versatile click chemistry glycan linker which enabled us to create glycan derivatives for use in microarrays, Luminex (bead based arrays) and ELISA assays. Check it out in @acs.org ACS Central Science doi.org/10.1021/acsc... #glycotime #clickchemistry #luminex

Novel Click Coupling Chemistry to Explore Glycan Recognition

Specific recognition of glycans by proteins is important in many biological processes and immune responses. Here we present a general approach for derivatizing free glycans with a novel linker MTZ (3-...

doi.org

Woefully missing from this review is any mention of #glycotime, when there are now so many publications and biopharma companies active in this space.

Nature Biotechnology@natbiotech.nature.com · last yr.

Turn cold tumors hot by reprogramming the tumor microenvironment - @mdanderson.bsky.social go.nature.com/42Bo9lT

#glycotime

Danve Castroverde@danvec.bsky.social · last yr.

Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology @science.org www.science.org/doi/10.1126/...

Dr. Hudson Freeze and Dr. Michael Tiemeyer @flyglyco.bsky.social on Capitol Hill Day organized by @faseborg.bsky.social and @sfglycobiology.bsky.social , advocating for federal funding in the glyco domain and beyond! #glycotime

✨✨ It's #glycotime for #HIV Env ✨✨ N-linked glycans modulate flexibility & MPER epitope exposure #glycotime Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪 Would love feedback! www.biorxiv.org/content/10.1...

🚀 Exciting News! 🚀 Our project developing therapeutic carbohydrate-based molecules to reduce risk of organ transplant rejection has been 🌟 awarded ca. 1 million CHF 🌟 from @snsf-ch.bsky.social 🎉 🥂 We are so excited to embark on this journey over the next 4 years! @unibas.ch #GlycoTime

Check out our new review on induced proximity modalities (#TPD and a lot more!) aimed cell surface targets @naturebiotech.bsky.social, spearheaded by postdocs Nick Till and "Rahm" Ramanathan www.nature.com/articles/s41...

Induced proximity at the cell surface - Nature Biotechnology

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.

nature.com

In the latest interesting facts about #glycans, we take a look at two tiny #glycolipids which are critical for life. Read the full post at: research.bidmc.org/ncfg/blog/17... For more interesting facts: research.bidmc.org/ncfg/interes... #glycotime #glycofacts

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy! www.nature.com/articles/s41...

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature

Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

nature.com

A POGase is a huge advance in the glycomics field, which has typically relied on chemical or incomplete enzymatic releases (no Sia). Expect a lot of multi-omic studies enabled by this (N-glycomics, O-glycomics, and proteomics) since the peptide backbone is left intact. www.nature.com/articles/s41...

We have an opening! If you are looking for a great postdoc fellowship in Boston - then check out this opportunity to work on antibody production against glycan antigens: research.bidmc.org/ncfg/careers... Please re-share to spread the word #glycotime #glycocareers #postdoc

In our latest interesting fact about #glycans we take a look at the most abundant #glycoprotein found in #urine, and how its glycosylation and function varies under different genetic physiological conditions. Read more at: research.bidmc.org/ncfg/blog/16... #glycotime #uromodulin

How could you not want to study glycans and polysaccharides when we’re surrounded by them?

Would you like to see more #XSharing posts where we reshare #glycotime content from other platforms here? Example 👇

The NCFG@thencfg.bsky.social · 2y ago

#XSharing from Sriram Neelamegham The paper highlights that #Glycotime is critical for all tested beta-CoVs, not just #SARS-CoV-2! www.nature.com/articles/s44...