Excited to share our new paper on our latest technology development: GlycoStrips Full paper open access: www.cell.com/trends/biote... #glycotime #glycobiology #pointofcare #diagnostics #immunemonitoring #immunity #antibodies #glycans

Point-of-care GlycoStrips detect serum and salivary antibodies to blood group antigens and pathogens

We present the development of GlycoStrip, which is a multiplex anti-glycan antibody analysis platform. GlycoStrip incorporates neoglycoproteins and other materials directly printed on nitrocellulose s...

cell.com

Check out fascinating insights on nature’s most abundant polymers in our latest blog post. 🌱 Cellulose 🦀 Chitin (found in insects & fungi) 💪 Hyaluronan 🍚 Starch 🦠 Peptidoglycan Read research.bidmc.org/ncfg/blog/27... #Glycobiology #Science #Biochemistry #Nature #CellBiology #Glycotime

Coconuts

"We identified 13 genome-wide significant loci associated with SARS-CoV-2 infection. The strongest signal was a single nucleotide polymorphism in an intron of ST6GAL1 (...) connected to three other associated loci (harboring MUC1, MUC5AC and MUC16)" #glycotime 🧪 www.nature.com/articles/s41...

Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants - Nature Genetics

Genome-wide analyses identify 13 loci associated with susceptibility to infection with SARS-CoV-2 Omicron variants, including variation in ST6GAL1, previously associated with influenza susceptibility,...

nature.com

But Joao, aren’t you afraid of being scooped? No. It’s an ultra-rare childhood epilepsy. If you scoop me and the kids get help from it, I will help you scoop me and then move on.

Joao Pereira@jdpereira.bsky.social · 5mo ago

Hey, I’ve got a childhood epilepsy R01 I’m writing - it’s mechanistic, focusing on calcium and cytoskeleton. Waaaaay out of my wheelhouse, and I’d love to get expert’s input for my specific aims - any takers to have a quick look at my page and just absolutely wreck it?

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...

GlycoShape@glycoshape.org · 5mo ago

Silvia's simulations showed that while all epitopes expose Sia for binding, Siglec-6 recognises and binds only GM1 because of a key interaction with the membrane through W127 and K126, which orientates the V-set domain to bind the Sia through Arg122 and the terminal Gal to the C-C' loop 😎

The Glycomics Core at Beth Israel Deaconess Medical Center is looking for a Postdoctoral Research Fellow with LC-MS/MS proteomics/glycoproteomics experience. For more information check: research.bidmc.org/ncfg/careers... #proteomics #glycomics #glycoproteomics #lcms

#GGDB (GlycoGene) in #ACGG-DB is a database focusing on glycogenes within #GlyCosmos and provides key information—including substrate specificity—on glycosyltransferases and sulfotransferases to support glycosylation/glycan biosynthesis analysis across species #glycotime

This is amazing work! #glycotime

Ethan Goddard-Borger@ethangbaus.bsky.social · 6mo ago

🚨 Our new paper is out today in Nature Chemical Biology: “Pan-specific antibodies to uncover bacterial pseudaminylation” doi.org/10.1038/s415... This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself. 1/6

Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX

Enzyme catalyzed bioorthogonal chemistry published at ACS Cent Sci pubs.acs.org/doi/10.1021/...

Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling

Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...

pubs.acs.org

Exciting new work from @thewoolab.bsky.social just out @nature.com www.nature.com/articles/s41...

Identification of an allosteric site on the E3 ligase adapter cereblon - Nature

An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.

nature.com

#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.

The NCFG@thencfg.bsky.social · 7mo ago

Have you ever wondered how many N-Glycans or #glycoproteins there are on cells? The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell! Read the full blog post: research.bidmc.org/ncfg/blog/24... #glycobiology #glycotime #cells #biology

The rate of global mean sea level rise has increased from ~2.1 mm/year in 1993 to ~4.5 mm/year in 2023. www.nature.com/articles/s43...

The rate of global sea level rise doubled during the past three decades - Communications Earth & Environment

Global mean sea level rise amounted to 4.5 mm per year as a result of warming oceans and melting land ice, more than twice the rate of 2.1 mm/year observed at the start of satellite data in 1993, base...

nature.com

Happy new year 2026 #glycotime! 🥳 We just introduced some useful options to Re-Glyco Ensemble. In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,

OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy www.federalregister.gov/documents/20...

Notice of Request for Information; Accelerating the American Scientific Enterprise

The Office of Science and Technology Policy (OSTP) requests input from all interested parties on Federal policy updates that aim to accelerate the American scientific enterprise, enable groundbreaking...

federalregister.gov

Happy birthday to us! 🥂🎂🥳 We are only 2 yo, but so much #glycotime happened since Dec 2023! ⬇️🧵 We truly appreciate your support, you fabulous glycoengineers around the world and we have so many exciting new tools for you coming up in 2026 to make your 3D glycoforms even better and faster! 🤩

Have you heard of sugar alcohols / artificial sweeteners, such as erythritol, sorbitol, mannitol and xylitol? Learn more about these interesting small sugars and where they are found in our latest blog post, research.bidmc.org/ncfg/blog/23... #glycotime #glycosylation #science #artificialsweeteners

Gut mucin fucosylation dictates the entry of botulinum toxin complexes www.nature.com/articles/s41...

Gut mucin fucosylation dictates the entry of botulinum toxin complexes - Nature Communications

Botulinum toxins vary in oral toxicity, but the reasons are unclear. Here, the authors show that the differences can be due to variations in one of the toxin’s components, the hemagglutinin complex, w...

nature.com

For some unique #glycotime: C-man is a rare (but evolutionarily very old[1]) post translational modification of proteins, where the C2 of Trp in W-x-x-W/C sequons are linked to a single man through a C-C bond 🤯 This and its position within the structure stabilises the (unusual for man) 1C4 chair[2]

Cannot hide my joy, relief, excitement being able to share the outcome of persevering (to say the least) collaborative work. So... the MS glyco(proteomics) guidelines are published!! www.mcponline.org/article/S153... Many thanks to @beilstein-institut.bsky.social @glycosmos.bsky.social @sib.swiss

Update and new implementation of the MIRAGE reporting guidelines for mass spectrometry experiments in glycoscience

The MIRAGE (Minimum Information Required for A Glycomics Experiment) guidelines for mass spectrometry (MS) data were initially developed to standardize the reporting of instrumentation, data acquisiti...

mcponline.org

We are excited to share our #glycotime meeting report on the 1st GlyCosmos Symposium & Jamboree in *Glycobiology*! DOI: doi.org/10.1093/glyc... Participants advanced glycan-binding molecule resources through hands-on work on lectin curation and FAIR glycoinformatics within #GlyCosmos.

Meeting Report on the 1st GlyCosmos Symposium & Jamboree —Community-Driven Expansion of Glycan-Binding Molecules Resources

Chiaki Nagai-Okatani, Masae Hosoda, Winnie Hsiung, Takashi Sato, Hiroaki Sakaue, Sayaka Fuseya, Eriko Fukuda, Issaku Yamada, Kiyoko F Aoki-Kinoshita, Atsus

doi.org

It's finally here! serversideup/php v4 is now stable 🎉 😅 Over a year of work 🐘 FrankenPHP & Laravel Octane support 🤖 LLM integration on our docs 🤝 13 new contributors ❤️ All open source Run PHP and Laravel anywhere you want. Now go build awesome stuff, Internet. 🚀

Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field. 1. RNA-associated glycoconjugates highlight potential ambiguities in glycoRNA analysis 2. Proteins are a source of glycans found in preparations of glycoRNA

Zeshi Li (Jack)@lizeshi.bsky.social · 9mo ago

#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇 Kim et al. rdcu.be/eP4GQ @nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)

Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!

Hiren Joshi@glyco.me · 10mo ago

employment.ku.dk/faculty/?sho... Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!

The @nuxt.com team is highly underrated 💯 I'm working with Nuxt Content, and this product blows my mind 🤯 It's easy, flexible, and fast. Open sourcing Nuxt UI was a solid move too. You know you're crushing it when a SERVER GUY compliments JavaScript 🤓

Sharing our recent pre-print where we drill down further into the transcriptional regulation of Siglec ligands. Here we show that tissue specific regulatory networks dictate changes in sialoglycan patterns. Work led by Rebecca Garnham and postdoc Adam Duxfield. www.biorxiv.org/content/10.1...

The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer

Glyco-immune checkpoints have recently been shown to be critical mediators of immunotherapy resistance across multiple cancer types. In clinical trials, immunotherapeutic treatments for prostate cance...

biorxiv.org

Breaking down fucoidan takes some innovative thinking, but evolution already got it! #glycotime 🧪🔺 "Remarkably, two-thirds of the interacting residues are dedicated to the recognition of sulfate groups along the glycoside chains." 🤯😍 www.nature.com/articles/s41...

Structure-function relationship of the GH168 fucanase reveals an unusual enzyme recognition mechanism for sulfated polysaccharide - Nature Communications

Authors identify and characterize 16 endo−1,3-fucanases within the GH168 family sequence space, unveiling a recognition mechanism for sulfate polysaccharides. These findings can promote the applicatio...

nature.com

You're kidding me!? 👀 TIL about "post_start" in Docker Compose 🐳 You can run commands as a privileged user on startup, but still run your services as an unprivileged user. This dramatically simplifies bootstrapping an app! 🤩

serversideup/php v4.0-beta1 is now available!!! It's a next level Docker image: 🐘 FrankenPHP now available ❤️ Improved native health checks 🤖 Advanced Laravel automations 🤩 12 new contributors Our biggest open source release yet. LET'S GO PHP!! 🚀