Wordle 1,852 4/6* When the solution is also a reaction to the solution ⬜🟨⬜🟨⬜ 🟨⬜🟨⬜⬜ ⬜🟩⬜🟩⬜ 🟩🟩🟩🟩🟩

Re-reading the Hallmarks reviews in prep for a lecture. Given how critical redox mechanisms and ROS-generating pathways are to oncogenic transformation and cancer metabolism, I can’t believe redox dysregulation isn’t an official hallmark of cancer. Fellow ROS biologists - time to mount a campaign?

Made me think of ‘30 Rock’… Wordle 1,775 4/6* 🟩🟨⬜⬜⬜ 🟩⬜🟨⬜⬜ 🟩🟩⬜⬜🟨 🟩🟩🟩🟩🟩

Excited for #SfRBM2025! Anyone else here heading to DC?

Sometimes I think Wordle is just trolling us… Wordle 1,550 3/6* ⬜⬜⬜⬜🟨 🟨🟩🟨⬜⬜ 🟩🟩🟩🟩🟩

STUDY: Denmark tracked over a million children for 21 years, and found vaccines linked to zero extra cases of autism, asthma, or 48 other conditions. Vaccines are safe, effective, and the best way to eradicate preventable disease. Period.

I never fail to be blown away by the intricate beauty of the Blaschka glass flowers at the Harvard Museum of Natural History. The skill and dedication that went into making these botanical specimens is just mind-boggling.

A fine example of Nature and nurture

Rakyan Lab@rakyanlab.bsky.social · last yr.

Paper in Nature 150 years ago. Beats reading any single-cell experiment…

My 8th and final year as director of our SURF program - it’s grown a bit from the three students in the year I first took over😃 Couldn’t ask for a better person than our new director @chvolmar.bsky.social to take SURF upwards and onwards!

just one of many small actions you can take that make a huge difference in your community, especially now in the face of SNAP cuts — and seriously, no one can stretch a dollar like a food bank

brat prince summer@anachronistique.bsky.social · last yr.

as the wise @nicolechung.bsky.social suggested I've just set up a monthly donation to my local food bank, and I'm gonna see if I can start volunteering there again. it ain't much but it's somethin

Never thought I’d miss having a Twitter account but here we are…

My Canadian university, Queen's, is offering TWENTY 4-year funded PhDs (40k CAD/yr) for a student of ANY citizenship who has been accepted at a top 100 US university but have had offer rescinded OR are reconsidering offer due to US policy. Details found here👇 www.queensu.ca/grad-postdoc...

I don’t know who needs to hear this but it’s more important than ever now to remember institutions don’t love you back. Focus on your science, your trainees and collaborators, and your own well-being. Institutions will always find a way to move the goalposts.

The President's Budget request as released yesterday will gut scientific research. Why should you care? 1) Science is fundamentally a jobs program. Many 100,000s are employed to do science and work for you, the US taxpayer.

Thank you @itaiyanai.bsky.social for an exciting research seminar and an engaging Night Science workshop! People are still buzzing about all the cool stuff they learned during your visit. (Loved the reminder to seek out science buddies who raise our game and encourage new thinking - very timely).

An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...

Measurements of molecular size and shape on a chip

Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...

science.org

My wonderful undergrad Bhipasha received the Outstanding Honors Thesis in Biology award for her project characterizing metabolic dysfunction markers in our obesogenic prostate cancer model. Seeing my trainees thrive and succeed right now gives me so much hope.

We are looking forward to your visit @itaiyanai.bsky.social

Itai Yanai@itaiyanai.bsky.social · last yr.

Miami friends! I'm looking forwarding to see you this Friday, May 9th, at my seminar on cellular adaptation in cancer and a Night Science mini workshop, on the Creative Scientific Process! Location: Sylvester Support Services Building Auditorium (1430 NW 11th Avenue)

Looking to hire a PhD level scientist with a solid tumor biology background to work with us on an exciting translational project centered on redox-regulated signaling and metabolism in cancer. Here’s the link (please re-post!): careers.miami.edu/us/en/job/R1...

My chocolate mint has come back to life so many times, it’s basically on the path to attaining nirvana…

Bethany Brookshire@beebrookshire.bsky.social · last yr.

I frantically repotted CM and prayed and with in 24 hours it's like a new plant. I scolded peppermint and told it it was a bully. Peppermint undaunted.

Quick question for New PIs: We’re hosting a New PI Success Essentials Workshop next Friday, April 11, from 10am to 2pm ET. Given the challenging circumstances many of you are facing, we’re making this session free for PIs in the US. Consider it our small contribution ;)

Today’s happy place - spending the day listening to some amazing cutting-edge science at our annual Tumor Biology symposium. Great talks from external speakers Drs Koumenis, Akbay and Cunniff as well as from our stellar faculty and trainees!

Check our recent work on a CRISPR screen to identify regulators of human somatic cell reprogramming where we identify USP22 as an important factor. Now published @CommsBio. rdcu.be/ed1l6

A chromatin-focused CRISPR screen identifies USP22 as a barrier to somatic cell reprogramming

Communications Biology - Ubiquitin-specific peptidase 22 (USP22) is identified as a key chromatin-based barrier to human iPSC derivation through a chromatin-focused CRISPR-Cas9 screen.

rdcu.be

Much will be written about how 4 PhD students and a PhD –Colette Delawalla, Sam Goldstein, Emma Courtney, Leslie Berntsen & JP Flores – organized @standupforscience.bsky.social to unite scientists in the US and worldwide. Now let's keep the momentum going to defend science! bsky.app/starter-pack...

Today’s positive was belting “Science is real” with They Might Be Giants and 100s of fellow S Floridians. A scientific theory Isn't just a hunch or guess It's more like a question That's been put through a lot of tests And when a theory emerges Consistent with the facts The truth is with science

Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling | Science www.science.org/doi/10.1126/...

Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling

Maintaining glucose and lipid homeostasis is crucial for health, with dysregulation leading to metabolic diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction–associated fatty liv...

science.org

This thread really brought home to me why the mental load is so crushing right now. Academic research requires so much planning ahead, risk management and handling uncertainty even at the best of times. Now, key support structures for our problem-solving are falling apart.

Gwen Snyder is uncivil@gwensnyder.bsky.social · last yr.

When I was talking a lot about getting prepared for FEMA cuts and trade war, someone told me apologetically needed to mute me because it was stressful hearing about preparation they couldn't afford to do. That's a huge stress right now for ALL of us, I think-- there is no getting fully prepared.

Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...

2025 Study section tracking

docs.google.com

If you haven't read this scathing email from an EPA fed to Lee Zeldin yet, do yourself a solid and check it out: www.muellershewrote.com/p/exclusive-...

EXCLUSIVE: Email from a Federal Worker at EPA to Lee Zeldin

I have obtained a copy of - and permission to publish - an email sent from Jason Poe to the EPA Administrator Lee Zeldin. Jason has asked me to share this email, along with his name, with the public.

muellershewrote.com

From an email viewed by me sent from the acting NIH director Matthew Memoli just a bit ago: "The last few weeks have been difficult for many of us, but we must prepare for further changes ahead. When this transition is behind us, NIH might look different... but our mission will remain unchanged."