How does Mycobacterium tuberculosis safely eat an antimicrobial (host-derived long-chain fatty acids)? Here we show that it’s not through a dedicated mechanism but rather by fine tuning its metabolism. www.nature.com/articles/s42...

A snip of the idea behind TRICK-TB, a project in collaboration with my good friend @robertsjansen.bsky.social funded by @caixaresearch.bsky.social @i3suporto.bsky.social (Interview in Portuguese/ Robert’s contributions in English) www.saudemais.tv/video/412549...

Saúde +

Ciência Agora - T02 E010 - Sandra Cardoso Oliveira

saudemais.tv

Mycobacterium tuberculosis is an outlier in many ways. One of them is keeping a high degree of functional redundancy despite its obligate pathogen lifestyle. In this review, we reflect on the biological meaning of M. tuberculosis functional redundancies. journals.plos.org/plospathogen...

Essential redundancies fuel Mycobacterium tuberculosis adaptation to the host

Redundancy in biology is, at a glance, counterintuitive because if the function of two gene products completely overlaps then, throughout the course of evolution, one of the genes will likely accumula...

journals.plos.org

An excellent summary of what we’re doing in the scope of our @caixaresearch.bsky.social project TRICK-TB funded by Fundación ”la Caixa”, together with some personal notes. Thank you to Observador for highlighting Portuguese science. [interview in Portuguese] observador.pt/especiais/o-...

O cientista que está a reinventar o tratamento da tuberculose

No Instituto de Investigação e Inovação em Saúde, no Porto, Tiago Beites quer forçar o bacilo da tuberculose a provar o seu próprio veneno. O objetivo? Melhorar o tratamento contra a doença.

observador.pt

Congratulations @alexandregouzy.bsky.social and @pierresantucci.bsky.social!!

SFM Microbial Pathogenesis@sfmpathogenesis.bsky.social · last yr.

New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky ✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll. 📖 shorturl.at/tuz6Q

Our favorite technician @alexjpinto.bsky.social just got awarded with a PhD fellowship. Here’s to 4 years of exciting research in our team 🥂

📣 Save the date: III ERA Chair #ImmunoHUB Annual Meeting! 📅 December 5 🔗 immunohub.i3s.up.pt/iii-immunohub-… ‼️Stay tuned for more info!

Please consider passing around this very informative interview to everyone you know (especially non-scientists). I believe it does an excellent job explaining why taxpayers benefit from the federal government’s support of scientific research. www.pbs.org/video/breakt...

Amanpour and Company | Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Season 2025

David Liu joins the show.

pbs.org

As the U.S. Government endeavors to make tuberculosis great again, please consider preordering a signed copy of my book about our deadliest infection, its long history, and why in the 75 years since TB became curable, we've allowed over 150,000,000 people to die of the disease. everythingistb.com

Authoritarians promising to protect free speech and then acting like authoritarians. Who would expect that?

EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment. But how does EtfD work? And how can you assay its activity? In his final PhD manuscript @courbongautier.bsky.social provides answers! www.biorxiv.org/content/10.1...

Long-chain fatty acids can be carbon sources for pathogens but are also potent antimicrobials. In our latest work, we explored the question of how Mycobacterium tuberculosis avoids getting killed by a preferred carbon source. www.biorxiv.org/content/10.1...

The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection

The human pathogen Mycobacterium tuberculosis (Mtb) thrives in lipid-rich microenvironments. Long-chain fatty acids (LCFA) are some of the most abundant lipids encountered by Mtb during infection. Mtb...

biorxiv.org

Today is the 24th of March and it's World TB Day. We typically have many activities to educate and raise awareness about TB and how important it is for us all to commit to doing more to end TB! This year feels different though.

For World TB Day, PIH is hosting a webinar at 12pm EST to discuss the repercussions of recently slashed US foreign aid and the hope that remains. #worldTBday @partnersinhealth.bsky.social Register here: act.pih.org/worldtbday2025

Register | Turmoil, TB Care, & Taking Action

Join experts on World TB Day to discuss the history, innovations, and social justice impact of TB, the world’s deadliest infectious disease.

act.pih.org

In this current political environment it is more important than ever to highlight the #WorldTBday. Let’s keep bending the arc.

I’ve been thinking quite a bit on what will be our job as scientists in the AI era. I’m starting to think it will be all about finding new and meaningful questions.

AI cracks superbug problem in two days that took scientists years - BBC News

The lead researcher has told the BBC he was so astounded he assumed his computer had been hacked.

www-bbc-co-uk.cdn.ampproject.org

Today is Dr Paul Farmer's 3rd death anniversary A good day to remember the lessons he taught us, even as we face the chaos caused by the US administration's attacks on science, and global health www.forbes.com/sites/madhuk...

Paul Farmer’s Moral Clarity Offers Hope, Amidst Chaos And Darkness

On the 3rd anniversary of Dr Paul Farmer's death, several leaders reflect on his lessons for dealing with the ongoing crisis in global health and development

forbes.com

Excited to have contributed to this fascinating study led by Rafael Prados Rosales! Uncovers how M. tuberculosis regulates extracellular vesicle production via VirR, shedding light on cell envelope remodeling & potential therapeutic targets! #MicroSky @elife.bsky.social doi.org/10.7554/eLif...

Huge thanks to @marcopsilva.bsky.social, Thales Costa and all the students for the kind invite to speak at the @i3suporto.bsky.social Student symposium! 🌟 Top-notch organization, amazing vibes, and a truly warm welcome, an unforgettable experience! 🙏 #i3Ssymposium

First time at #EMBOtuberculosis presenting a part of my PhD work through a flash talk and poster presentation. Great to finally meet the TB community! Incredible experience in India, with amazing science, wonderful people, and delicious food! 🇮🇳

What a great conference #EMBOtuberculosis has been! Amazing science, amazing food and a very friendly community! And it was a pleasure to share the work we’re developing at i3S U. Porto.

Esperar pelos resultados da FCT parece a emoção da Eurovisão. A quem vai dar a Estónia os 12 pontos?

Hi5 for everyone that submitted The grant today! What a journey!

🎉 Thrilled to share the first paper by @saurabhchugh09.bsky.social, a talented Marie Skłodowska-Curie fellow in our lab! Discover how the exometabolome acts as a hidden driver of bacterial virulence and pathogenesis #MicroSky @cp-trendsmicrobiol.bsky.social www.sciencedirect.com/science/arti...

The exometabolome as a hidden driver of bacterial virulence and pathogenesis

The traditional view of metabolism as merely supplying energy and biosynthetic precursors is undergoing a paradigm shift. Metabolic dynamics not only …

sciencedirect.com

A very special one. My dear friends @healycl.bsky.social and @alexandregouzy.bsky.social published a paper with our common mentor @saehrt.bsky.social. On top of that, this is Alex’ first corresponding authorship!! And, of course, excellent bacterial physiology science.

Alexandre Gouzy@alexandregouzy.bsky.social · 2y ago

Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt.bsky.social and @healycl.bsky.social without who this would not have been possible 😘 journals.asm.org/doi/10.1128/...

Ignorant drug development question. What’s missing on target-based drug development to make it truly useful? As opposed to the unbiased compound library screens that seem to be the gold standard. I may or may not be thinking on organizing a symposium to address this question.

Introducing my wonderful team at i3S - University of Porto. PhD student @marcopsilva.bsky.social and research fellow @alexjpinto.bsky.social

TRICK-TB is up and running! Collaboration with Robert Jansen with the support of CaixaResearch, laCaixaFoundation.

TB contributed to the extinction of Neanderthals? 😶 www.livescience.com/archaeology/...

Asking the void: are there good examples of compounds that targeted both host and pathogen enzymes (homologues) that were successfully modified/optimized to be selective for the pathogen’s enzyme?