Elena Seiradake @kavlioxford.bsky.social and co-workers @ox.ac.uk @renalucl.bsky.social present crystal structures of the CD177 ectodomain and a CD177-PR3 complex, revealing a major autoantibody epitope. -> link.springer.com/article/10.1...

Our new tool to analyze protein interfaces from MD trajectories is out in JMB, in its Computational Resources Special Issue! 🍀 Our tool, DynaPIN can be used to understand the biology of binding at the atomistic scale, as we have showed in its paper at doi.org/10.1016/j.jm... For more details👇👇👇

A. Berçin Barlas@aysebercinb.bsky.social · 3w ago

🎉 Finally out!! Our paper, "DynaPIN: A tool for characterizing dynamic protein interfaces" is accepted in JMB! @ezgikaraca.bsky.social (in collaboration with @sacquin-mo.eurosky.social & co.) DynaPIN is an open-source pipeline for analyzing dynamic protein interfaces. 🧵👇 📄 doi.org/10.1016/j.jm...

Ancestral neuronal receptors are bacterial accessory toxins pubmed.ncbi.nlm.nih.gov/41690916/ #cryoEM

For 47 years, Iranians have risen up thousands of times to reclaim the greatness they lost. In these final moments of their fight, stand with them as they take back their country's freedom. #IranRevolution #KingRezaPahlavi #IranRevolution2026 #DigitalBlackoutIran

Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing pubmed.ncbi.nlm.nih.gov/41264251/ #cryoEM

Yay! Our findings on the antidepressant drug vilazodone binding to the serotonin transporter (SERT) are out! We used cryo-electron microscopy and other advanced biophysics to provide data suggesting two high affinity binding poses. www.nature.com/articles/s41...

Structural basis of vilazodone dual binding mode to the serotonin transporter - Nature Communications

The serotonin transporter (SERT) is a key antidepressant target. Here, authors present a cryo-EM structure where the antidepressant vilazodone spans the main SERT binding site toward a secondary ...

nature.com

At some point, Doppio will replace relion's gui. Already you can do more in Doppio than in relion! 🤩

Collaborative Computational Project for Electron cryo-Microscopy@ccpem.bsky.social · 9mo ago

We are pleased to announce Doppio version 1.4! Available here www.ccpem.ac.uk/software/dow...

Frequent user of epitope tags? Try ours! IPI epitope tag antibodies & plasmids are now available through our partner @addgene.bsky.social! buff.ly/YEuZDIp

Epitope tag antibody collection

Epitope tags are short amino acid sequences fused to a protein’s N- or C-terminus. When paired with an antibody that specifically recognizes this sequence, epit

buff.ly

Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!

SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

nature.com

I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome. We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.

Check out this fascinating study on a fungal multipass translocon! What's really neat is how they did it: cryo-EM structure from the endogenously tagged and purified SND3 complex. It will be exciting to see if there is any potential for SBDD against fungi, Trypanosoma, and Leishmania (?).

Melanie McDowell@melaniemcdowell.bsky.social · last yr.

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

We are excited to present the first #cryoEM structures of human GABA transporter 3 – GAT3 – bound to an in-house selective inhibitor, SR-THAP, to substrate GABA, and in the substrate-free state! @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Structural basis for selective inhibition of human GABA transporter GAT3

The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signalling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy f...

biorxiv.org

Yes, please. I go with Nemesis drones and like their motto "to see means to win": www.dronynemesis.cz/en.

Collection for 20 000 FPV drones

dronynemesis.cz

Petr Svoboda@svobodalab.bsky.social · last yr.

Anyone can provide Ukraine with more drones. For example via these two Czech sites: dronynemesis.cz/en weaponstoukraine.com/kampane/drony Or you can just helplessly watch what's happening there. Retweets help for sure.

Oh yeah, P-types ❤️💙💛 and the copper one, ATP7B! It was a great day full of science. Thank you so much everyone for being involved!

Charlott Stock@charlottstock.bsky.social · 2y ago

Huge congrats to @tomasheger.bsky.social who succesfully defended his PhD yesterday. Such a joy to supervise with @tdieudonne.bsky.social and @poulnissen.bsky.social. Big thank you to @melaniemcdowell.bsky.social, @henrietteautzen.bsky.social and Daan van Aalten for a great discussion. P-type ❤️💙💛

Thank you so much for guiding me on this amazing journey, @poulnissen.bsky.social, @charlottstock.bsky.social, and @tdieudonne.bsky.social. So great and thorough discussion with @melaniemcdowell.bsky.social, @henrietteautzen.bsky.social and Daan van Aalten. I highly appreciate your involvement.

Thibaud Dieudonné@tdieudonne.bsky.social · 2y ago

🎉Congrats @tomasheger.bsky.social for this excellent PhD defense. You were the expert in the room. Very very proud supervisors with @charlottstock.bsky.social and @poulnissen.bsky.social ! Many thanks to the jury members Daan van Aalten, @henrietteautzen.bsky.social and @melaniemcdowell.bsky.social