#ImmunometabolismPower! Excited to share our review @cp-cellchembiol.bsky.social with super-talented @tristramryan.bsky.social about the activity of immunometabolites of the #TCA #Krebs cycle working as metabolic damage-associated molecular patterns #metaDAMPs in health & disease!

Metabolic danger signals: TCA cycle metabolites regulate immunity and disease

Mitochondrial tricarboxylic acid (TCA) cycle metabolites have emerged as critical regulators of immunity and inflammation beyond their canonical metab…

sciencedirect.com

Journal club article by @tomikostevc.bsky.social & @sawitzkilab.bsky.social discussing a recent #preprint from @sciencekyle.bsky.social that uses a synthetic cytokine receptor to simultaneously induce inflammatory and phagocytic phenotypes in a macrophage rdcu.be/ftTPx

Excited to share a highlight that Birgit Sawitzki and I wrote about a recent preprint on fine-tuning macrophage polarization using synthetic cytokine receptors from the @sciencekyle.bsky.social Lab! @preprintclub.bsky.social

#InterferonPower #InflammasomePower! Thrilled for our 💥#NewPaper💥 @natimmunol.nature.com spearheaded by Kautilya Jena showing that our #fungal adjuvant #Mannadjuvant prolongs & potentiates protection of mRNA vaccines via #IL1b & #IFNs, broadening it to new variants & overcoming antigenic imprinting!

A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines

Nature Immunology - Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by...

rdcu.be

Two of our lab members, Christina Iwert and Lev Petrov, have recently successfully defended their PhD theses! Congrats and wishing you both loads success in your careers! 🎓 @woodenrobo.bsky.social

💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...

Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons

Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...

doi.org

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

Excited to share our new study on how age-related changes in STAT signaling impact antiviral responses and hyperinflammation in COVID-19! 🧵 Explainer thread by the first author Lev Petrov linked below ⬇️

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

Petrov et al. identify an age-dependent shift in interferon signaling during SARS-CoV-2 infection, with older individuals favoring a STAT3-driven inflammatory response. This mechanistic insight helps ...

cell.com

📣 Job alert! 📣 We are are looking for a talented bioinformatician to join us at the Berlin Institute of Health at Charité to analyze multiomics data in post-COVID-19 and ME/CSF syndrome research. Please share and come join us! ⬇️ #ImmunoSky #Bioinformatics #Immunology #ComputationalBiology #MedSky

Computational Scientist (d/f/m) in Translational Immunology

Vollzeit | 16.04.2025 | BIH Berlin Mitte

bihealth.org

Leaving Boston in a few days after a productive time in the Zanoni Lab at @bostonchildrens.bsky.social and Harvard Medical School. Huge thanks to Ivan @lozanzi.bsky.social and the whole lab for their support and inspiration. I will miss you all! Excited to keep working together on cool science! 🤩

Ivan Zanoni@lozanzi.bsky.social · 2y ago

#Bittersweet! Today we say goodbye to Tomi Kostevc, an amazingly talented international PhD student in the lab that did an amazing work on #DendriticCell biology (#FirstLove!)! Physically back to @ChariteBerlin @CharitePhdnet, but we will keep doing more cool #science together 😎!!