Honored to be part of the Schmidt Science Fellows family! Excited for this pivot to bring discoveries to real-world impact, and deeply grateful to my mentor @junyuecao.bsky.social, labmates, collaborators for their unwavering support, and @rockefeller.edu for an exceptional training environment!

The Rockefeller University @rockefeller.edu · 8mo ago

Zehao Zhang (@tommyz626.bsky.social), a graduate fellow in the Cao lab (@junyuecao.bsky.social) at Rockefeller, has been selected as a 2026 Schmidt Science Fellow for his work on how the immune system regulates itself and what causes it to fail. Congratulations!

New paper alert 🚀 Our organism-wide single-cell ATAC-seq atlas of mammalian aging is now out in @science.org, led by our fantastic graduate student Ziyu Lu from @rockefeller.edu! www.science.org/doi/10.1126/...

Interested in the mechanisms of aging and 'rejuvenation'? Our lab at Stanford has a Research Assistant/Lab manager position open!! Apply and join our awesome team! 😎 (please share) careersearch.stanford.edu/jobs/life-sc...

Life Science Research Professional 1 in School of Medicine, Stanford, California, United States

The Brunet lab in the Department of Genetics at Stanford University (https://web.stanford.edu/group/brunet/) is seeking an independent and motivated.....

careersearch.stanford.edu

We have posted a Research Assistant (LSRP1) position to work on aging and 'rejuvenation' using mouse models!! 🐭 careersearch.stanford.edu/jobs/life-sc... Apply and join our awesome lab!! (please share) 😎

New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)

Lineage recording in monoclonal gastruloids reveals heritable modes of early development

Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...

biorxiv.org

Why do many aging interventions come & go, yet Caloric Restriction (CR) remains a robust pillar, extending healthspan across species? Its benefits are even noted in ancient eastern texts like The Yellow Emperor’s Classic of Internal Medicine!

The importance of the immune system for healthy aging. A large multi-cohort study identifies a mechanism of immune resilience with substantial impact for outcomes onlinelibrary.wiley.com/doi/10.1111/...

The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging

Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health-promoting trait (more common in women) linked to strong i....

onlinelibrary.wiley.com

Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of

Biological sex is a key modifier of #aging phenotypes, including #Brain 🧠 aging. See this piece out today in #Neuron, spearheaded by @denadubal.bsky.social, co-authored by #YousinSuh, @ctmurphy1.bsky.social and myself on the topic: www.sciencedirect.com/science/arti... #GeroSky #SexDifferences

Interested in brain aging? We are super excited to share our new review!! "Brain aging and rejuvenation at single-cell resolution" 🧪🧠 Massive CONGRATS to Eric Sun, Rahul Nagvekar, and Angie Pogson, three phenomenal graduate students in the lab!! authors.elsevier.com/sd/article/S...

A newly created atlas of 21 million cells from @junyuecao.bsky.social's lab led by @tommyz626.bsky.social could upend long-held assumptions about how we age and provide fresh directions for anti-aging therapies. #RockefellerScience

Study reveals how unexpected shifts in cell populations are revising our understanding of the aging process - News

A newly created atlas of 21 million cells could provide fresh directions for anti-aging therapies.

rockefeller.edu

Joined @junyuecao.bsky.social's lab without knowing single-cell genomics - after 3 years of failing, crying, learning, and growing, I’m proud to share the PanSci! Huge thanks to amazing mentors Jun & Wei and support from @rockefelleruniv.bsky.social. The secrets of aging are starting to unfold!

Junyue Cao@junyuecao.bsky.social · 2y ago

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!