Excited about our new manuscript @elife.bsky.social: Engulfment by brain macrophages in a short-lived vertebrate doi.org/10.7554/eLif...! Huge congratulations to Rahul Nagvekar and the team!! ✨⭐🍾🐟 We generated a genetic model to identify engulfing macrophages in the #killifish aging brain!

Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science. Today @nature.com, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/

Talked about "How We Age" on Kara Miller's "It Turns Out" podcast - links here - podcasts.apple.com/us/podcast/h...

How to extend life - and where the science stands

Podcast Episode · It Turns Out · July 24 · 39m

podcasts.apple.com

Our new paper on lipids in neural stem cell aging!! Congratulations to Xiaoai Zhao for her fantastic work! ✨🥂 www.science.org/doi/10.1126/...

Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging

Plasma membrane lipids are remodeled with age in neural stem cells, and rejuvenating membrane lipids boosts old cell function.

science.org

4D Nucleome special issue of Science, featuring our paper "Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor", led by Zoe Grant in my lab and Zhuzhen Kuang in Katie Pollard's lab @gladstoneinst.bsky.social www.science.org/toc/science/...

What if an embryo made immune cells before it finished building the tissue they usually come from? In our new preprint, we show that annual killifish embryos specify neutrophils before germ layers are fully resolved. www.biorxiv.org/content/10.6... Huge thanks to my PI, @ohnolog.bsky.social ! 🧵

Early immune cell development precedes gastrulation in annual killifish

During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

biorxiv.org

"Then, in 2021, the Princeton University geneticist Coleen Murphy found that Caenorhabditis elegans worms could learn to avoid a pathogenic bacterium by eating, or even just swimming around in, pureed worms who had learned the hard way." www.quantamagazine.org/are-memories...

Are Memories Transferable — or Edible? | Quanta Magazine

In the 1960s, worm-training experiments and their strange implications captivated the nation. Columnist Claire L. Evans follows the neuroscientists who attempted to recapture the magic.

quantamagazine.org

Planning a Perturb-seq experiment? Building virtual cells? First step to good models is good data. How many cells to profile? How deeply to sequence? What statistical power? Check out PerturbPlan — new tool from Ziang Niu in Katsevich Lab www.perturbplan.com www.biorxiv.org/content/10.6...

Thrilled to see this out today in PLOS Biology. With postdocs Siqi Liu and Flávio Costa, we ask why the gut microbiome loses its balance with age. It's an Unsolved Mystery piece: a framework, not a finalized account, with predictions we lay out for the field to test. 🧵

PLOS Biology@plosbiology.org · 3mo ago

Host-associated microbiomes are stable across most of the lifespan, but what drives late-life deterioration remains unclear. @dvalenzano.bsky.social &co propose interventions that restore #immune surveillance capacity alongside ecologically informed #microbiome management. 🧪 #aging

Why do guinea pigs have so many natural bypass arteries — and mice and humans almost none? We develop in vivo Perturb-seq for endothelial cells to ask how protective collateral arteries are built. Preprint with by Irene Fan, Ronghao Zhou, and Kristy Red-Horse: www.biorxiv.org/content/10.6...

Interested in aging and rejuvenation? We have a new Research Assistant position to understand aging at the cellular level!! Come join our team!!! 😎 careersearch.stanford.edu/jobs/life-sc...

Life Science Research Professional 1 in School of Medicine, Stanford, California, United States

Stanford University is seeking a Life Science Research Professional 1 to study the mechanisms of aging and rejuvenation, particularly in a variety of....

careersearch.stanford.edu

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis

Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

science.org

Excited to share a pre-print from a collaboration between my lab at NIH, Len Petrucelli's lab at University of Miami, and Shyamal Mosalaganti's lab at University of Michigan.

Have you ever wondered why mice do what they do when they are free to do whatever they want? Check out our latest (and this slightly delayed thread about our recent paper, led by Caleb Weinreb and friends...) www.cell.com/neuron/fullt...

Spontaneous behavior is a succession of self-directed tasks

Weinreb et al. reveal a hierarchy of timescales in mouse behavior, including low-level syllables and high-level behavioral states. States and syllables are encoded in different brain areas. Prefrontal...

cell.com

Online now! A new study shows transplanting gut microbiota from estropausal female mice to young adult female mice improves ovarian hormone profiles, follicle metrics, and fertility-related outcomes. @bbparis1984.bsky.social doi.org/10.1038/s435...

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature Aging

To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

doi.org

Aging may feel gradual… but what if it’s not? In our recent paper, we tracked fish continuously from puberty until death. This gave us a unique view of how aging unfolds across the adult lifespan. 🧵

Great work from Claire, Ravi, and the whole team– the initial lifelong continuous screen of behaving vertebrates provided a wealth of ideas on progression/staging of brain function across lifespan. Behavior is unmatched as a noninvasive quantitative readout of brain function (and, one that matters).

Zebrafish Rock!@zebrafishrock.bsky.social · 5mo ago

Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2

Lifelong behavioral screen reveals an architecture of vertebrate aging | Science Was a wonderful collaboration with @clairebedbrook.bsky.social, Libby Zhang, Scott Linderman, @brunetlab.bsky.social & @deisseroth.bsky.social www.science.org/doi/10.1126/...

Lifelong behavioral screen reveals an architecture of vertebrate aging

Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behaviora...

science.org

Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2

🧪 New from incoming LSI faculty Claire Bedbrook & Ravi Nath, from @brunetlab.bsky.social's lab: www.science.org/doi/10.1126/... 🧪

Lifelong behavioral screen reveals an architecture of vertebrate aging

Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behaviora...

science.org

On today's podcast, we talk with neuroscientists Claire Bedbrook and Ravi Nath about their new study, which found that an animal's lifespan can be predicted surprisingly early by observing its behavior. @brunetlab.bsky.social @deisseroth.bsky.social 🔗 neuroscience.stanford.edu/news/why-do-...

Multi-organ transcriptomic aging atlas in killifish, with both males and females! 🐟🐟🐟 Huge congratulations to Emma, Jing, Tony and the entire team!! ✨⭐ @emkcosta.bsky.social @jingxunchen.bsky.social Wyss-Coray lab! www.nature.com/articles/s43...

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish - Nature Aging

Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

nature.com

Online now! Costa, Chen et al. performed RNA-seq on 13 tissues, six ages in male and female African turquoise killifish. The Killifish Aging Atlas provides a comprehensive resource for aging studies. @emkcosta.bsky.social @jingxunchen.bsky.social @brunetlab.bsky.social doi.org/10.1038/s435...

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish - Nature Aging

Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

doi.org

Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!! Congratulations to Paloma Navarro and the entire team! Fantastic collaboration with Chris Garcia's lab, Tony Wyss-Coray's lab, and Saul Villeda's lab! www.cell.com/immunity/ful...

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear. Navarro Negredo et al. dissect how aging impacts brai...

cell.com

We have posted a Research Assistant (LSRP1) position to work on aging and 'rejuvenation' using mouse models!! 🐭 careersearch.stanford.edu/jobs/life-sc... Apply and join our awesome lab!! (please share) 😎

Interested in the mechanisms of aging and 'rejuvenation'? Our lab at Stanford has a Research Assistant/Lab manager position open!! Apply and join our awesome team! 😎 (please share) careersearch.stanford.edu/jobs/life-sc...

Life Science Research Professional 1 in School of Medicine, Stanford, California, United States

The Brunet lab in the Department of Genetics at Stanford University (https://web.stanford.edu/group/brunet/) is seeking an independent and motivated.....

careersearch.stanford.edu

New episode (1211), with Dr. Coleen Murphy (@ctmurphy1.bsky.social). We talk about her book, How We Age: The Science of Longevity. #Biology #Science YouTube: youtu.be/Fy22JhtHhdU Podcast: bit.ly/4a1fCh8

#1211 Coleen Murphy - How We Age: The Science of Longevity

YouTube video by The Dissenter

youtu.be

We are hiring!! Lab Assistant II position to work with the killifish! 🐟🐟🐟 This is an amazing model to study aging and 'suspended animation' careersearch.stanford.edu/jobs/lab-ass... Come and join our fantastic team at Stanford!! 🤩 Please share!

Join us for an awesome Keystone Symposia in Banff, Canada in March 2026! Fantastic line up of speakers at the juncture between immunity and aging!! www.keystonesymposia.org/conferences/...

📣 Deadline extension for #EMBOBrainEpi! Good news for anyone who did not submit an abstract for the EMBO Workshop 'Brain (epi)genome': the abstract deadline is now 26 January 👉 s.embl.org/brg26-01-bl Join us to explore how genome and epigenome shape brain cell diversity, function, and disease 🧠