Congratulations to Ella. The shared vs niche-specific split is the useful part: 'inflammaging' gets discussed as one thing, and a cross-tissue meta-analysis is what shows where the signature is common vs where tissue context rewrites it. On the reading list.

Shared and niche-specific transcriptional signatures of macrophage aging revealed by a cross-tissue meta-analysis link.springer.com/article/10.1...

Shared and niche-specific transcriptional signatures of macrophage aging revealed by a cross-tissue meta-analysis - BMC Biology

Background Aging is accompanied by widespread transcriptional remodeling across tissues, yet how aging impacts different categories of tissue-resident macrophages is not well understood. Macrophages a...

link.springer.com

a rare example of a science figure that looks like a shitpost which is just photos of real events: babies trying to climb into tiny toy cars, sit on tiny toy chairs, and slide down tiny toy slides doi.org/10.1126/scie... (fig. 1)

Shared and niche-specific transcriptional signatures of macrophage aging revealed by a cross-tissue meta-analysis https://link.springer.com/article/10.1186/s12915-026-02672-x #genomics #Bioinformatics

Happy to share this new work by excellent Benayoun lab PhD Candidate #EllaSchwab, out today #BMCBiology: "Shared and niche-specific transcriptional signatures of macrophage aging revealed by a cross-tissue meta-analysis" @uscleonarddavis.bsky.social 1/4 🧬🖥️🧪🐁 link.springer.com/article/10.1...

Across mouse tissues, aging macrophages shifted toward stress and damage responses, but the pattern was not uniform. Brain and lung macrophages showed distinct age-related changes, and sex-related differences also appeared. doi.org/hcbkqw

Scientists discover how macrophages age differently throughout the body

Why does the immune system become less effective as we age? A new USC study published in BMC Biology offers fresh insights by examining a key immune cell type across tissues: macrophages.

medicalxpress.com

Finally, in their Essay, @bbparis1984.bsky.social &co argue that accounting for both sex and age is essential to advancing personalized medicine, considering the interactions between these factors and the immune system plos.io/4wkqdgd

The problem with one-size-fits-all medicine: Biological sex and the aging immune system

Aging has effects on the immune system that are similar in men and women, but also reshapes their immune systems in unique, sex-specific ways, however these differences are rarely taken into considera...

plos.io

📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com

A memorable #commencement ceremony today, where I had the honor to hood my talented trainee Dr. Ryan Lu! @uscleonarddavis.bsky.social 🎓🎊🍾

Aging can reshape the immune systems of men and women in unique, sex-specific ways. @bbparis1984.bsky.social &co argue that accounting for both sex and age is essential to advance personalized medicine. 🧪 #aging #immunity #SexDifferencesDay #WomensHealthWeek

The problem with one-size-fits-all medicine: Biological sex and the aging immune system

Aging has effects on the immune system that are similar in men and women, but also reshapes their immune systems in unique, sex-specific ways, however these differences are rarely taken into…

plos.io

Happy to share our new essay led by fantastic trainees 🔥🔥🔥 Clayton Baker, Victor Ansere and Cossette Sanqui: "The problem with one-size-fits-all medicine: Biological sex and the aging immune system" Here, we argue that any #personalized medicine must account for #sex for success. Enjoy the read!

PLOS Biology@plosbiology.org · 3mo ago

Aging can reshape the immune systems of men and women in unique, sex-specific ways. @bbparis1984.bsky.social &co argue that accounting for both sex and age is essential to advance personalized medicine. 🧪 #aging #immunity #SexDifferencesDay #WomensHealthWeek

Aging can reshape the immune systems of men and women in unique, sex-specific ways. @bbparis1984.bsky.social &co argue that accounting for both sex and age is essential to advance personalized medicine. 🧪 #aging #immunity #SexDifferencesDay #WomensHealthWeek

The problem with one-size-fits-all medicine: Biological sex and the aging immune system

Aging has effects on the immune system that are similar in men and women, but also reshapes their immune systems in unique, sex-specific ways, however these differences are rarely taken into…

plos.io

Aging can reshape the immune systems of men and women in unique, sex-specific ways. @bbparis1984.bsky.social &co argue that accounting for both sex and age is essential to advance personalized medicine. 🧪 #aging #immunity #SexDifferencesDay #WomensHealthWeek

The problem with one-size-fits-all medicine: Biological sex and the aging immune system

Aging has effects on the immune system that are similar in men and women, but also reshapes their immune systems in unique, sex-specific ways, however these differences are rarely taken into…

plos.io

🚨 New lab preprint alert! 🚨 A study 6 years in the making, made possible by @simonsfoundation.org support : "A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging" now on #biorXiv: www.biorxiv.org/content/10.6... A 🧵 1/11 🧪🖥️🧬

A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging 🤩 @bbparis1984.bsky.social doi.org/10.64898/202...

A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging www.biorxiv.org/content/10.6...

🚨LA and SoCal trainees: Submit your abstracts for #GLAM2026 - we have 16 grad/postdoc talk slots and 12 undergraduate talk slots! 🚨

Bérénice A. Benayoun, PhD@bbparis1984.bsky.social · 4mo ago

🔥 Attention Los Angeles and SoCal Geroscience trainees 🔥: Registration and abstract submission for the 2026 ✨ Geroscience Los Angeles Meeting (GLAM) ✨ are open: gero.usc.edu/laara/event/... #GLAM2026 will take place September 4th, 2026 at the California Science Center 🧪 🔬 👩‍🔬 👨‍🔬 1/2

🔥 Attention Los Angeles and SoCal Geroscience trainees 🔥: Registration and abstract submission for the 2026 ✨ Geroscience Los Angeles Meeting (GLAM) ✨ are open: gero.usc.edu/laara/event/... #GLAM2026 will take place September 4th, 2026 at the California Science Center 🧪 🔬 👩‍🔬 👨‍🔬 1/2

A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging https://www.biorxiv.org/content/10.64898/2026.04.09.717549v1

🚨 AGE VOYAGER Grants are OPEN! 🚨 ✔️ Up to $5,000 ✔️ For AGE trainee members (grad students & postdocs) ✔️ Supports travel, lodging, registration, childcare & more 🗓 Deadline: Jan 12, 2026 #AGEVoyager #AgingResearch #Geroscience #ResearchFunding #AGE

🚨 New lab preprint alert! 🚨 A study 6 years in the making, made possible by @simonsfoundation.org support : "A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging" now on #biorXiv: www.biorxiv.org/content/10.6... A 🧵 1/11 🧪🖥️🧬

🔥 Attention Los Angeles and SoCal Geroscience trainees 🔥: Registration and abstract submission for the 2026 ✨ Geroscience Los Angeles Meeting (GLAM) ✨ are open: gero.usc.edu/laara/event/... #GLAM2026 will take place September 4th, 2026 at the California Science Center 🧪 🔬 👩‍🔬 👨‍🔬 1/2

Please share with your #killifish colleagues 🐟 #ZebrafishMeeting

Zebrafish Information Network (ZFIN)@zfinmod.bsky.social · 4mo ago

[Meeting] African Turquoise Killifish Conference 2026, October 1-3, 2026, MDI Biological Laboratory, Bar Harbor, ME

Beyond depressing situation for aging research funding in the US.

Jeremy Berg@jeremymberg.bsky.social · 5mo ago

12/25

12/25

Retired NIH Program Officer Requests Grandson Address Weaknesses From Last Year’s Christmas List Before Considering New Submission open.substack.com/pub/inprepar...

Retired NIH Program Officer Requests Grandson Address Weaknesses From Last Year’s Christmas List Before Considering New Submission

BETHESDA, MD—Explaining that he needed to see substantial revision before proceeding, retired NIH program officer Harold Wexler, 74, informed his grandson Sunday that he would need to address weakness...

open.substack.com

Excited to share our study "Estropausal gut microbiota transplant improves measures of ovarian function in adult mice" ♀️🐁💩 led by Dr. #MinhooKim, published online today at @nataging.nature.com, where we describe surprising findings on the gut/ovary axis. 🧪🖥️🧬. A 🧵1/11 www.nature.com/articles/s43...

Happy Women's Day! Is there a better way to celebrate than reading the latest 📄 on our fav. female cells? 👉🏼 biomed.news/bims-cebooc/... Highlight: pubmed.ncbi.nlm.nih.gov/41776310/ by @bbparis1984.bsky.social on the role of microbiota in ovarian aging! powered by @biomednews.bsky.social #cebooc

Online now! A new study shows transplanting gut microbiota from estropausal female mice to young adult female mice improves ovarian hormone profiles, follicle metrics, and fertility-related outcomes. @bbparis1984.bsky.social doi.org/10.1038/s435...

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature Aging

To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

doi.org

✨Registration is OPEN for the 2026 FASEB on Epigenetics in Aging and Disease in Malahide, Ireland!✨ Featuring @denadubal.bsky.social and Yang Shi from @ludwigcancer.bsky.social as Keynotes. Speaker slots available! With: @bbparis1984.bsky.social Ashby Morrison, Ernesto Guccione