Tyler Ryan Sizemore

@tsizzle2.bsky.social

Post-doc in @CarlsonLab_Yale. Insectophile. Sensory Neurobiology. Social Media Coordinator for @CSHLflycourse. #FirstGen. He/Him. Opinions are my own. tylersizemore.com

The White House budget proposal for FY27 slash NSF funding by more than 50% and would drastically reduce support for PhDs, postdocs & investigator-initiated research. Selling something is not the same as doing something. Science is hard. This 'new golden age' won't make it easier.

US NSF announces

"Science: A New Golden Age Summit"

Washington
Discover the frontier

Excited to share this work from @darbly.bsky.social's lab and my lab with @davidhildebrand.bsky.social @briandepasquale.bsky.social and many others! It turns out that the sensory neurons that detect CO2 in Aedes aegypti mosquitoes have lots of recurrent connections! 🦟👃🌟

PLOS Biology@plosbiology.org · last wk.

CO2 is an important cue used by #mosquitoes when searching for a human blood meal. @darbly.bsky.social @megyounger.bsky.social &co show that the wiring of #neurons that sense CO2 differs from that in #Drosophila, allowing robust detection of this key host cue @plosbiology.org 🧪 plos.io/4cFCPpV

Feedforward connectivity of maxillary palp glomeruli. Top left: Schematic with feedforward OSN-to-PN connections highlighted. Top right: Dendrograms (flattened 2D representations of the 3D dendritic arbor preserving distance information) of uPNs and their incoming feedforward synapses from OSNs. * denotes branch leading to soma, and arrow denotes branch leading to the inner antennocerebral tract (iACT). (top) uPN cable length, glomerular volume, and cable density. Scale bar 100 µm. Bottom left: Coronal view of uPN reconstructions. Scale bar 25 µm. Bottom right: Axograms (flattened 2D representations of the 3D axonal arbor preserving distance information) of representative OSNs with their feedforward synapses to uPNs shown as colored dots. Scale bar 25 µm.

a good summary of how we got here and what it means. i would add is that everyone who works with the fly connectome datasets knows that they all far from "complete". each one, though monumental, has major reconstruction/annotation issues, not to mention the lack of a peripheral nervous system.

Patrick Mineault@patrickmineault.bsky.social · 6d ago

Are virtual flies playing Beat Saber? SM64? Doom? No. The new fly connectome is an incredible achievement! Less is going on in the sim videos than it seems. I'm stoked to see people engage with neuroscience though. My breakdown: www.neuroai.science/p/are-flies-...

🚨 The NIH is moving to transfer hundreds of millions of dollars in infectious-disease research projects to the DOD under a secret 10-year pact. Here’s what’s happening inside “Operation Prevailing Edge” 🧵👇 www.nature.com/articles/d41...

Revealed: inside the US military's plan to tap huge sums from the NIH

An agreement paves the way for hundreds of millions of dollars’ worth of projects to be transferred from the NIH’s institute for infectious diseases to the Department of Defense.

nature.com

We have lived in Davis for 7 years and last night was the first time I have ever gone to watch the bats come out. We were gifted with an amazing sunset too! It was amazing! Huge props to Yolo Basin Foundation for a fantastic tour and event. 🦇 🌅 1/

Do you work with microscopy images and segment to quantify or track? Do you study cell biology? development? Gather round! Let me tell you about FOCUS-3D, a segmentation algorithm that is fast, accurate and can be used on any model. We used it here to study zebrafish development. 🧪 (thread)

FOCUS‑3D: Robust, generalizable volumetric cell segmentation for three‑dimensional fluorescence microscopy

Understanding how cells establish spatial organization within tissues is a fundamental question in life sciences. While modern three-dimensional fluorescence microscopy captures large-volume tissue ar...

biorxiv.org

The ratio on this is hilarious Spare yourself this stream of narcissism and condescension that willfully misrepresents what unionization actually does (e.g: "The value of a good postdoctoral fellowship is not to be measured in salary but in the opportunity to learn at the feet of, yes, a master.")

Inside Higher Ed @insidehighered.com · 3w ago

Opinion | Postdocs Aren’t Burger Flippers: Why Unionization Is a Bad Idea Unionization disrupts the bespoke mentor-mentee relationships that are central to the advancement of science. By Evan D. Morris: https://bit.ly/3Sus7fa #EDUSky #AcademicSky #HigherEd

A drawing of a god-like hand, inspired by Michelangelo's painting in the Sistine Chapel, pointing to a sign, "Talk to the Union Rep: Local 1508."