#ECP22 Hungry for more on personality polygenic indices after @tuckerdrob.bsky.social’s brilliant keynote? Come to our symposium tomorrow at 16:45! virtual.oxfordabstracts.com/event/75621/...
New meta by @peterhaehner.bsky.social et al (I'm a little middle author) on individual differences in personality change across the lifespan (229 studies, N = 230k) 10.1037/bul0000525 Cool finding (imo): For all Big Five, variance in change is greatest in youth, declining through young adulthood!
New review, forthcoming in the Annual Review of Developmental Psychology: "From Seconds to Seasons and Days to Decades: Timescales in Development." Let me walk you through some key points. 👇 BC its a review, these are based on many others' work. osf.io/preprints/ps... 1/
1/9 🚨 BREAKING OUT OF STEALTH MODE 🚨 Multivariate GWAS in Genomic SEM now runs on a laptop! New preprint + package update: a closed-form analytic solution makes multivariate GWAS ~800× faster, cutting runtimes from hours on HPC clusters to minutes on a personal computer.
The Predator Emerges
ALT: The Predator Emerges
static.klipy.com
Just submitted an Abstract to WCPG 2026 in Glasgow, left it very late. @drmoab.bsky.social and I are organizing a fun social run for conference atendees! Nothing set in stone yet but given the difference in pace between Mo and I we might have 2 pace groups 😅! Like,share, get in touch if interested!
Age at diagnosis is gaining attention in autism research. AaD is heritable, with genetic factors influencing whether someone is diagnosed earlier or later. The genetic correlation is only moderate, suggesting differing genetic profiles. Commentary: doi.org/10.1038/d415... #autism #genetics
Early- and late-diagnosed autism are genetically distinct
Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development.
doi.org
We're hiring! FT research assistant @ UT Dallas Join our team to work on a longitudinal neuroimaging study of midlife brain aging. Strong opportunity for those interested in brain networks, aging, and Alzheimer’s disease risk. App. deadline May 6. Details: jobs.utdallas.edu/postings/31680
Humans live many more years than mice, but our brain networks are aging much faster. Brain network decline follows a common trajectory across mouse and human adulthood, with features of network organization linked to more rapid decline. www.pnas.org/doi/10.1073/...
This piece really nails how I have been feeling in the last couple of weeks. fortune.com/2026/02/11/s...
Something big is happening in AI — and most people will be blindsided | Fortune
It’s not like a light switch... more like the moment you realize the water has been rising around you and is now at your chest.
fortune.com
Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/202...
Genomic insights into substance use and disinhibitory disorders
Externalizing spectrum disorders- spanning attention-deficit/hyperactivity disorder, conduct disorder, substance use disorders, and other disorders characterized by disinhibition - frequently co-occur...
doi.org
I wrote about the bizarre case of Herasight, the embryo selection company going all in on eugenics.
Embryo selection company Herasight goes all in on eugenics
...
open.substack.com
For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7
Andrew Grotzinger@andrewgrotzinger.bsky.social · 8mo ago1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
Mapping the genetic landscape across 14 psychiatric disorders - Nature
Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...
nature.com
I wrote about missing heritability, "missing environmentality," and why I still think twin studies are interesting and valuable: kathrynpaigeharden.substack.com/p/twins-are-...
Twins Are So Much More Interesting Than Heritability Estimates
On starting places, "missing environmentality," and the Waddington landscape of life
kathrynpaigeharden.substack.com
1/ 🚨New paper in Nature Genetics Genetic factors are associated with the educational fields people study, from arts to engineering. Article: www.nature.com/articles/s41... FAQ: www.thehastingscenter.org/genomic-find...
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
nature.com
Non-paywalled link to my commentary on @vw1234.bsky.social and colleagues new paper in @nature.com rdcu.be/eI2NG
Early- and late-diagnosed autism are genetically distinct | Nature
Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development. Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development.
rdcu.be
Varun Warrier@vw1234.bsky.social · 10mo agoThis was a fantastic collaboration with lots of people including @hilarycmartin.bsky.social @jakobgrove.bsky.social, Experts by Experience, and several others who I can't seem to find on this app. Article: www.nature.com/articles/s41...
This was a fantastic collaboration with lots of people including @hilarycmartin.bsky.social @jakobgrove.bsky.social, Experts by Experience, and several others who I can't seem to find on this app. Article: www.nature.com/articles/s41...
Polygenic and developmental profiles of autism differ by age at diagnosis - Nature
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
nature.com
And a very helpful and informative commentary on the paper by @tuckerdrob.bsky.social www.nature.com/articles/d41...
Early- and late-diagnosed autism are genetically distinct
Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development.
nature.com
Keynote speakers: @tuckerdrob.bsky.social @foswald.bsky.social Ellen Hamaker Hands-on workshops by: @tedmond.bsky.social & @ukuvainik.bsky.social (genomic analyses) @dirkwulff.bsky.social (LLMs in personality research) www.ecp22edinburgh.org/programme
A deep and thought-provoking lecture that is definitely worth watching all the way through.
Eric Turkheimer@ent3c.bsky.social · 12mo agoMy Dobzhansky lecture at BGA: "Theodosius Dobzhansky and the Origins of Radical Behavior Genetics" is publicly available. I talk about the tensions introduced into the field at the difficult border between science using model organisms and human beings. Thanks to BGA for the opportunity.
A few related conversations have been converging on the question of when various trends and observations with respect to personality are genuine. This is a complex issue without a simple answer... A key issue is that personality is best measured using self- or informant ratings... 1/
Michel Nivard@michelnivard.bsky.social · 12mo agoWhile I am not entirely convinced this is “real” and not some psychometric equivalent of a vowel shift (and PRS could help find out a bit I think) this it is relevant:
Psychiatric Genetics Beyond Heritability: Q&A with Michel Nivard ( @michelnivard.bsky.social ) “We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.” www.psychiatrymargins.com/p/psychiatri...
Psychiatric Genetics Beyond Heritability: Q&A with Michel Nivard
We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.
psychiatrymargins.com
Humbled to receive the BGA's early career award ☺️ Thank you to my brilliant team #MPRGBiosocial, the @maxplanck.de for investing in early career researchers, @mpib-berlin.bsky.social for the excellent environment, and my many mentors incl @kph3k.bsky.social @tuckerdrob.bsky.social #ScienceTeamSport
Behavior Genetics Association@behaviorgenetic.bsky.social · last yr.🏆 @laraffington.bsky.social won the early career award, and Paul Liechtenstein won the Dobzhansky award
Omg 😂. Well played @michelnivard.bsky.social
Michel Nivard@michelnivard.bsky.social · last yr.O, right I promissed JUICE! Not everyone believes in this work, one of the "haters" was very early... In fact @ent3c.bsky.social practically leant over this papers' crib and said: "well that's not going to be a looker."... Someone just as petty as me, but far more organized, kept the receipts 👇
O, right I promissed JUICE! Not everyone believes in this work, one of the "haters" was very early... In fact @ent3c.bsky.social practically leant over this papers' crib and said: "well that's not going to be a looker."... Someone just as petty as me, but far more organized, kept the receipts 👇
You will have seen this post by @tedmond.bsky.social on our new GWAS of Personality. He says you should read the paper (you should), I want to write a thread to entice you. Because social media has shredded your attention as it has mine, I promise there is JUICE & BEEF in this thread!
Ted Schwaba@tedmond.bsky.social · last yr.Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
Probably the most important paper in personality psych this decade just dropped. 👀 Interesting genetic correlations between other traits (the #1 reason for GWASs on social traits IMO), and evidence of weak but non-zero assortative mating on personality.
Ted Schwaba@tedmond.bsky.social · last yr.Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
🔥🔥🔥 2 years of our lives right there (extremely proud of everyone, I’ll write a thread later)
Ted Schwaba@tedmond.bsky.social · last yr.Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social
bioRxivpreprint@biorxivpreprint.bsky.social · last yr.An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1