Our article is on the COVER of this month’s issue of @cp-devcell.bsky.social! Congrats to all the authors for the hard work, especially Shota, Despina and @jamesbriscoe.bsky.social
@veronicabiga.bsky.social
Our ECR-led seminar series @physicsoflifeuk.bsky.social is restarting next Tuesday! We have fantastic speakers so don't forget to register! If you someone else is interested in presenting at the upcoming session register your interest by filling in this form lnkd.in/e95_ZTCK
An oscillatory dance of fate: HES1–HES5 dynamic co-expression precedes cell fate resolution in spinal cord development This Research Highlight showcases work by Veronica Biga, Cerys Manning @manning-lab.bsky.social and colleagues from @manchester.ac.uk. journals.biologists.com/dev/article/...
As Editor of @dev-journal.bsky.social I get asked "What are you doing about your impact factor?" In our new editorial we say: Ask not what Dev can do for the impact factor. Ask what you can do for Dev's IF The IF is about how we all cite, review & assess each other's work doi.org/10.1242/dev....
The elephant in the room: impact factor
Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...
doi.org
To learn more about this work and the people behind it, we talked to Veronica Biga and Cerys Manning. journals.biologists.com/dev/article/...
Read the Research Article 'Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif' here. journals.biologists.com/dev/article/...
Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif
Highlighted Article: Expression of the cross-repressing proteins HES1 and HES5 is mutually exclusive but when they oscillate, a cell can express both, creating a hybrid state that later resolves into…
journals.biologists.com
Our paper on HES1-HES5 is available online and we are excited that it was selected for a Research Highlight online piece!!
Development@dev-journal.bsky.social · 3mo agoAn oscillatory dance of fate: HES1–HES5 dynamic co-expression precedes cell fate resolution in spinal cord development This Research Highlight showcases work by Veronica Biga, Cerys Manning @manning-lab.bsky.social and colleagues from @manchester.ac.uk. journals.biologists.com/dev/article/...
Join us online later today for two great talks!
@physicsoflifeuk@physicsoflifeuk.bsky.social · 6mo ago📢 The next UK Physics of Life Network ECR led seminar, will take place on 10th March at 2 pm GMT (online). 🌍 The seminar is open to everyone – we’d love to see you there! Sign up for the link here: forms.gle/JWCMxtB8BLmn...
🚀 Physics of Life Student Summer Bursaries 2026 – NOW OPEN! Are you an undergrad curious about research at the interface of physics & biology? Or a supervisor with a keen student? 👉 Find out more & apply: www.physicsoflife.org.uk/summerbursar...
Just out! Fantastic work from @papalopululab.bsky.social showing bi-directional effects in HES1 and cell-cycle.
Papalopulu Lab@papalopululab.bsky.social · 6mo agoDynamics, dynamics, dynamics! We asked how ER+ breast cancer cells transition from dormancy to reactivation. Inspired by developmental biology, we show that HES1 protein oscillations change during this shift — and that disrupting these dynamics prevents reactivation. www.pnas.org/doi/10.1073/...
I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004
Great work from Mochulska & Francois developing a generative framework for systematically building Dynamical Landscapes of cell fate decision making using modular dynamical components Important step to interpretable and predictive models of cellular differentiation www.biorxiv.org/content/10.1...
biorxiv.org
Join us for the next @physicsoflifeuk.bsky.social PDRA-led Seminar: Tues 10 June | 🕑 2–3 PM BST | 💻 Zoom With talks from Petr Sherin & Darryl Overby (Imperial), chaired by @jcammann.bsky.social Register now for the Zoom link: forms.gle/epdhsHSW2JVv...
Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data" A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making Applied to ventral neural tube development www.biorxiv.org/content/10.1...
Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data
Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...
biorxiv.org
Excited to share that my latest preprint! We use dual reporters and computation to explore the bistable HES1-HES5 motif and find that oscillations enable a hybrid state characterised by synchrony of HES1 and HES5 resolving into single HES during the development of mouse embryonic spinal cord.
Papalopulu Lab@papalopululab.bsky.social · last yr.In our latest study by @veronicabiga.bsky.social, we explore how the “Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif”: www.biorxiv.org/content/10.1...
Congratulations to @anzymiller.bsky.social and the fellow PIs for being selected on a great career development opportunity!
James Briscoe@jamesbriscoe.bsky.social · last yr.Meet the 2025 @dev-journal.bsky.social Pathway to Independence (PI) fellows Eight developmental and stem cell biologists transitioning from postdoc to principal investigator journals.biologists.com/dev/pages/pi...
We're very excited to announce that our colleague @anzymiller.bsky.social is about to begin her @dev-journal.bsky.social Pathway to Independence journey! This will provide mentoring and support to emerging researchers in developmental biology and stem cells . journals.biologists.com/dev/pages/pi...
PI programme | Development | The Company of Biologists
PI programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our call for our Pathway to Independence program...
journals.biologists.com
Join us online today!
@physicsoflifeuk@physicsoflifeuk.bsky.social · last yr.We're excited to host two fantastic speakers at our next online @physicsoflifeuk.bsky.social ECR Seminar on Tuesday 15 April, 2–3 PM BST: Tisma Milos and Thomas McLean chaired by @veronicabiga.bsky.social Please register below for the Zoom link: lnkd.in/dSynrAe8
Join us online next Tuesday 15th April from 2-3pm UK time for another exciting Physics of Life ECR talk session!
@physicsoflifeuk@physicsoflifeuk.bsky.social · last yr.We're excited to host two fantastic speakers at our next online @physicsoflifeuk.bsky.social ECR Seminar on Tuesday 15 April, 2–3 PM BST: Tisma Milos and Thomas McLean chaired by @veronicabiga.bsky.social Please register below for the Zoom link: lnkd.in/dSynrAe8
We are also highlighting John Gurdon, 2012 Nobel laureate in Physiology or Medicine and former Chair of the Board of Directors at @biologists.bsky.social, as an extraordinary biologist. #100biologists
