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Vicente Planelles Herrero

@vicenteph.bsky.social

Senior Scientist playing with microtubules, cytoskeleton and motors in DeriveryLab MRC_LMB. Loves music, scifi and bad memes.

3 Posts213 Follower224 Folgt
Derivery Lab - MRC LMB@deriverylab.bsky.social · 2mo ago

Deeply honored to be elected as an EMBO member. This would not have been possible without the incredible past and present members of my lab - thank you for your dedication, creativity and total lack of fear over the years 🔬🪰🧪

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 2mo ago

Congratulations to LMB Group Leaders Emmanuel Derivery, Kelly Nguyen and Julian Sale, who have all been elected members of @EMBO.org! Read more about their research at the LMB here: mrclmb.ac.uk/news-events/... #LMBNews @deriverylab.bsky.social @kellythd-nguyen.bsky.social @juliansalelab.bsky.social

Portrait photographs of Julian Sale, Emmanuel Derivery and Kelly Nguyen
Mark Peifer (He, him)@peiferlabunc.bsky.social · 3mo ago

While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪

https://www.nature.com/articles/s41586-025-10004-2 Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC U. Sahin, M. Schmidt, E. Derhovanessian, A. Cortini, I. Vogler, T. Omokoko, E. Godehardt, S. Attig, S. Newrzela, J. Grützner, N. Bidmon, S. Bolte, S. Brachtendorf, T. Stuhlmann, D. Langer, D. Brüne, J. Blake, A. Feldner, H. Lindman, A. Schneeweiss, M. Eichbaum & Ö. Türeci Triple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. Here we assessed an individualized neoantigen mRNA vaccine in 14 patients with TNBC following surgery and after neoadjuvant or adjuvant therapy. In peripheral blood of nearly all patients, high-magnitude, vaccine-induced, mostly de novo T cell responses to multiple neoantigens were detected that remained functional for several years. Characterization of individual patients revealed that a large proportion of these T cells developed into two subsets: a late-differentiated phenotype with markers indicative of ‘ready-to-act’ cytotoxic effector T cells, and T cells with a stem cell-like memory phenotype. Eleven patients remained relapse-free for up to six years post-vaccination. Recurrence occurred in three patients: the individual with the weakest vaccine-induced T cell response relapsed, but achieved complete remission on subsequent anti-PD-1 therapy; another patient had a tumour with low major histocompatibility complex (MHC) class I expression with MHC class I-deficient cells growing out under vaccination; and the third patient was BRCA-positive and had a recurrence from a genetically distinct primary tumour. These findings demonstrate the feasibility of individualized RNA vaccines in TNBC, document persistence of vaccine-induced, functional neoantigen-specific T cells and provide insights into possible immune escape mechanisms that will guide future approaches.
Simon Bullock@simonbullock11.bsky.social · 4mo ago

Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...

Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology

Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...

nature.com

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 4mo ago

The hidden rules behind mRNA transport. A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs. Read more: mrclmb.ac.uk/news-events/... #LMBNews @cellbiol-mrclmb.bsky.social 🧪

Structural representation of the Egl-BicD-dynein-dynactin complex transporting an mRNA molecule along a microtubule, with a magnified inset of the Egl-BicD-RNA structure.
Glenn Carrington@drgcarrington.bsky.social · 4mo ago

🚨 New review out in @jmrcm-springer.bsky.social 🧬 From the @michellepeckham.bsky.social lab, we summarise how smooth muscle myosin is regulated—covering autoinhibition, filament assembly, and structural insights into motor control and disease. 👉 rdcu.be/feUiX

Smooth muscle contractile cytoskeleton in health and disease - Journal of Muscle Research and Cell Motility

Smooth muscle cells are widespread in the human body, found in a range of tissues from the vasculature to the gut, airways, bladder and so on. They can be found as isolated cells or organised into syncytia (groups of cells). The organisation of the contractile cytoskeleton (smooth muscle actin and myosin filaments) is less well understood than that of striated (cardiac and skeletal) muscle. This review aims to explore what is known, the potential effects of mutations in smooth muscle actin, myosin and tropomyosin and how they lead to disease, and to highlight what we have still to learn about the smooth muscle contractile cytoskeleton.

doi.org

Derivery Lab - MRC LMB@deriverylab.bsky.social · 6mo ago

🚨🚨🚨Check out this new preprint from the Löwe lab proposing that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis! Happy to have had a little contribution by showing that Asgard tubulin displays a key hallmark of eukaryotic tubulins: dynamic instability! 🚨🚨🚨

Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺@ettema.bsky.social · 6mo ago

Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis www.biorxiv.org/content/10.6...

Vicente Planelles Herrero@vicenteph.bsky.social · 6mo ago

Check this out! Very proud to see this out, always happy to play with "microtubules" in vitro 😍

Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺@ettema.bsky.social · 6mo ago

Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis www.biorxiv.org/content/10.6...

Derivery Lab - MRC LMB@deriverylab.bsky.social · 2y ago

🚨 Paper Alert 🚨 Our preprint describing Elongator as a selective microtubule polymerase that rewrites PTMs on microtubules is now published! Check it out: www.embopress.org/doi/full/10....

Elongator is a microtubule polymerase selective for polyglutamylated tubulin | The EMBO Journal

imageimageElongator, an established tRNA-modifying complex, can also stabilize microtubules during asymmetric cell division. This study shows that Elongator subcomplexes achieve this by binding to mic...

embopress.org

Cell Biology J-Club@cellclub.bsky.social · 2y ago

Elongator is a microtubule polymerase selective for polyglutamylated tubulin | The EMBO Journal www.embopress.org/doi/full/10....

Elongator is a microtubule polymerase selective for polyglutamylated tubulin | The EMBO Journal

imageimageElongator, an established tRNA-modifying complex, can also stabilize microtubules during asymmetric cell division. This study shows that Elongator subcomplexes achieve this by binding to microtubule ends as well as tubulin dimers, and ...

embopress.org