💥 New publication from the Demetriades and Nüchel groups– final version now online in EMBO reports! This Tour de force wouldn’t have worked out without the amazing support from our collaborators and core facilities!

GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi - EMBO Reports

Lysosomes are multifunctional organelles that play important roles in cellular recycling, signaling, and homeostasis, relying on precise trafficking and activation of lysosomal enzymes. While the Golg...

link.springer.com

We are still accepting applications for the PhD student position in our lab (deadline: May 1st)! Please spread the word!

vosslab@vosslab.bsky.social · 4mo ago

My lab in Kiel, Germany, studies the regulation of #glycosylation in the #Golgi apparatus and we are still looking for a motivated PhD student. Please spread the word/get in touch! #glycotime #SPPL3

Happy Golgi Day

My lab in Kiel, Germany, studies the regulation of #glycosylation in the #Golgi apparatus and we are still looking for a motivated PhD student. Please spread the word/get in touch! #glycotime #SPPL3

www.nature.com/articles/s41...

The 95th Harden Conference: Linking Golgi trafficking and glycan function taking place 23-26 June 2026 will bring together glycobiologists with the membrane trafficking community to kickstart new collaborations. Learn more here: https://ow.ly/9Eex50YguUY

Ten more days to apply! We are still looking forward to applications from students eager to study #SPPL3 and other proteases and their role in the regulation of #Golgi #glycosylation. #glycotime

vosslab@vosslab.bsky.social · 8mo ago

We are looking for a motivated PhD student to join our lab! #SPPL3 #glycotime #Golgi #UniKiel

Exciting conference next summer! Greatly appreciate the opportunity to present our work.

Biochemical Society@biochemsoc.bsky.social · 8mo ago

Our 95th Harden Conference: Linking Golgi trafficking and glycan function will explore topics of golgi organisation, glycosylation enzyme sorting, as well as golgi and glycans in pathology. Register your place now🧪 :https://www.eventsforce.net/biochemsoc/254/home

Congratulations to Master student Daniel Meisinger from our group who received a Research Festival Award for Outstanding Research Achievements for his poser presentation!

Universität Kiel (CAU)@uni-kiel.de · 8mo ago

💬 Beim zweiten Research Festival der Medizinischen Fakultät der #UniKiel standen der interdisziplinäre Austausch und die Forschung des wissenschaftlichen Nachwuchses im Mittelpunkt: 🔗: https://www.uni-kiel.de/de/detailansicht/news/206-researchfestival 📷: Kerstin Nees/Felix Lürssen, Uni Kiel

We are looking for a motivated PhD student to join our lab! #SPPL3 #glycotime #Golgi #UniKiel

Our institute's new website is online now: www.biochemie-kiel.de

Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!

Hiren Joshi@glyco.me · 10mo ago

employment.ku.dk/faculty/?sho... Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!

Reminder: our postdoc and PhD positions are still open. We work across different areas (wet and dry lab), but I am especially after people with a computational biology, bioinformatics, pytorch whisperer kind of background. Protein design and OpenFold/AF also counts.

Hiren Joshi@glyco.me · 10mo ago

employment.ku.dk/faculty/?sho... Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!

We will be hiring soon! #SPPL3 #glycotime #Golgi

SPPL3 again enters the spotlight...

Waggoner Lab@labwaggoner.bsky.social · 12mo ago

SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells @cellcellpress.bsky.social www.cell.com/cell/fulltex...

Regulation of podocyte surface proteins by the enzyme A Disintegrin And Metalloproteinase 10 (ADAM10) doi.org/10.1016/j.kint.2025.04.010 #OpenAccess #kidney #membranousnephropathy #MedSky #NephSky

Happy Golgi day

Great visit in Kiel Biochemistry with Elmar Wolf, Paul Saftig, M. Damme, M. Voß. Talking exciting (lysosome) science at the beautiful Kiel Fjord.

Our final 2024 issue! Highlight: New players in lysosomal sorting via mannose-6-phosphate mRNA deadenylation & decay relations Plant ALBA proteins facilitate m6A reading METTL3/MYCN cooperation and lots more! Cover: Grishma Rane, @denniskappei.bsky.social et al www.embopress.org/toc/14602075...

Interesting paper by Verkerk et al. further supporting that loss of #SPPL3 can lead to tumour immune evasion. onlinelibrary.wiley.com/doi/10.1002/...

Tumor‐Expressed SPPL3 Supports Innate Antitumor Immune Responses

Tumor and immune cells interact through receptor–ligand interactions. B3GNT5 produces nsGSL on tumor cells which is regulated by SPPL3. When SPPL3 is absent, elevated nsGSL levels hinder receptor–lig...

onlinelibrary.wiley.com

Please also have a look at the News & Views article by Nikita Zubkov and Sean Munro @cellbiol-mrclmb.bsky.social that accompanies our EMBO J paper: www.embopress.org/doi/full/10....

New players and targets in mannose 6-phosphate-dependent lysosomal sorting | The EMBO Journal

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

embopress.org

Out now in The EMBO Journal: Our collaborative new #Golgi #glycotime story, which shows (i) that B4GALT5, a Golgi enzyme, is subject to M6P tagging and (ii) that GOLPH3/GOLPH3L stabilize LYSET and the GlcNAc-phosphotranferase complex and thus are crucial to cellular M6P tagging. tinyurl.com/jkv26nhh