The Serology Puzzle: Untangling Cross-Reactivity in Arbovirus Diagnostics #arbovirus #surveillance #serology #modelling #epidemiology @vyman.bsky.social @mtwhite.bsky.social http://dlvr.it/TTVCNH
Victor Yman
@vyman.bsky.social
Infectious disease physician, post-doc at Institut Pasteur Paris, IDEA Unit. Research on the epidemiology and immunology of vector borne infections, mainly malaria and arboviruses
New blood test can distinguish between similar mosquito-borne viruses, thus contributing to better surveillance of how these infections spread #dengue #Zika #chikungunya @vyman.bsky.social @mtwhite.bsky.social
New blood test may improve mapping of mosquito-borne viruses
Mosquito-borne viral diseases such as dengue, Zika and chikungunya are spreading to new regions as the climate becomes warmer. A new study from Karolinska Institutet and Institut Pasteur, published in Nature Communications, shows that a newly developed blood test can distinguish between similar viruses and thereby contribute to better surveillance of how these infections spread.
dlvr.it
Excited to share our new paper out today in @natcomms.nature.com Combining multiplex serology, mathematical modelling, and experimental validation reveals arbovirus transmission dynamics despite cross-reactivity. (1/2)
Investigating antibody cross-reactivity and transmission dynamics of alphaviruses and flaviviruses using a multiplex serological assay - Nature Communications
Arboviruses often co-circulate, but cross-reactivity hampers serological diagnostics. Here, the authors paired multiplex serology with competitive immunoassays and Bayesian modelling to quantify antib...
nature.com
The final piece of my PhD work is now published in Science Translational Medicine! We present a new framework to jointly infer epidemiological and antigenic parameters from multi-pathogen population serological studies🦠 www.science.org/stoken/autho...
In a clinical trial, this new malaria drug cured 97.4% participants go.nature.com/3LGGZ6c
First new type of malaria treatment in decades shows promise against drug resistance
If approved, GanLum could be available within a year and a half, according to maker.
go.nature.com
Whose line is it anyway? Defining sero-positivity cut-offs for infectious disease surveillance ✅ Just Accepted #IDSky 🔗 https://bit.ly/4qoQdUq
From the now published pan-disease blood atlas, we used the proteomic data together with clinical and single-cell data to describe immune cross-talk linked with disease severity in malaria @cp-immunity.bsky.social Check it out! www.sciencedirect.com/science/arti... #Immunology #malaria @ki.se
Finding the tick-borne encephalitis cellular gateway could transform prevention and treatment go.nature.com/3Kqp5E9
How a tick-borne virus enters human cells
Tick-borne encephalitis virus can infect the nervous system and cause life-threatening illness. Finding the cellular gateway it uses could transform prevention and treatment.
go.nature.com
A new analysis of a cohort in Nepal links the waning of vaccine immunity against Japanese encephalitis virus to elevated chymase levels and a higher risk of severe #dengue infection. Read more in #ScienceTranslationalMedicine: https://scim.ag/45ORL27
Dengue disease severity in humans is augmented by waning Japanese encephalitis virus immunity
Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal.
scim.ag
New Research: Effectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo, Brazil: a test-negative, case–control study www.thelancet.com/journals/lan...
Effectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo, Brazil: a test-negative, case–control study
TAK-003 was effective against symptomatic dengue and hospitalisation with dengue in adolescents during a large outbreak caused predominantly by dengue virus serotypes 1 and 2. These findings underscor...
thelancet.com
Proud co‑author on @cp-immunity.bsky.social study by Julius Lautenbach, @chrissundling.bsky.social & Team Färnert w/ HPA & @scilifelab.se. We integrate plasma proteome dynamics (1500 proteins) + scRNA-seq in acute malaria, identifying severity markers & exploring immune-cell communication.
Systems analysis of clinical malaria reveals proteomic perturbation and innate-adaptive crosstalk linked to disease severity
While the immune response to Plasmodium falciparum malaria has been studied extensively, the circulating proteome and its cellular origins remain poorly characterized. Lautenbach et al. address this b...
cell.com
#NatMicroPicks E. coli making paracetamol from plastic waste! 🦠💊 A new biocompatible chemistry for plastic waste upcycling using microbes. #MicroSky #SynBio 🔧🧬 www.nature.com/articles/s41...
New-to-nature biocompatible chemistry for plastic waste upcycling - Nature Chemistry
Synthetic and biological chemistry are traditionally seen as separate fields. Now, a biocompatible chemical reaction enables an engineered microbe to convert plastic waste into valuable compounds unde...
nature.com
Executive Summary of State-of-the-Art Review: Modern Approach to Nocardiosis—Diagnosis, Management, and Uncertainties ⭐ Editor's Choice #IDSky
Executive Summary of State-of-the-Art Review: Modern Approach to Nocardiosis—Diagnosis, Management, and Uncertainties
Nocardia is a genus of gram-positive, partially acid-fast bacilli that typically infect people with chronic lung disease or immunocompromised states.
academic.oup.com
Potential first new antibiotic for gonorrhoea since the 1990s is effective and safe, finds trial. Explore the research ➡️ tinyurl.com/5bu2nbyt #ESCMID #ESCMIDGlobal
Beautiful study of primaquine treatment to prevent vivax malaria relapses from Jean Popovici's team from Pasteur Cambodia. The study is special because patients were moved to a non-endemic part of Cambodia, excluding reinfection from msoquitoes. authors.elsevier.com/sd/article/S...
Nature research paper: A natural experiment on the effect of herpes zoster vaccination on dementia https://go.nature.com/3XHRhq5
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of 7 years by approximately one-fifth.
go.nature.com
Serological data provide key insights on pathogen circulation. We introduce a new R package, Rsero, which is a pipeline to store and analyze age-stratified sero data, estimate the history of pathogen circulation and compare different transmission models. journals.plos.org/ploscompbiol...
RSero: A user-friendly R package to reconstruct pathogen circulation history from seroprevalence studies
Author summary Antibodies are immune markers of past infections. Seroprevalence studies that characterize the seropositivity status in the population have been used for decades in epidemiological stud...
journals.plos.org