IgD from atypical-like memory #Bcells and #plasmacells targets commensal and environmental antigens. By @rosertp.bsky.social, Bashour, Filipska, @victorgreiff.bsky.social, Cerutti et al. rupress.org/jem/article/... 📘 In our #Mucosal #Immunology collection: 👉 rupress.org/jem/collecti... #ICMI2026

✨ Where you publish matters. 🔬 Publishing in #EFIS Journals doesn't just share your research—it helps support fellowships, travel grants & awards for the European #immunology community. 🧬 Consider the @eurjimmunol.bsky.social or #ImmunologyLetters for your next manuscript. #AcademicPublishing

Hey team - it’s looking very likely that I’ll be hiring not one but two four year postdocs! We’re a fun lab with tons of theoretical and applied pop gen projects - broadly in polyploid, conservation, and human evo. Competitive salary, sunny San Diego! Do share with your about to defend grads!

Eli Lilly buying three companies with vaccines in the pipeline for shingles, Staphylococcus aureus and other bacterial pathogens, and flaviviruses like Zika and West Nile. A vote of confidence in vaccines! #IDsky #publichealth #virology #immunology

Lilly inks deals to buy 3 vaccine developers for up to $3.8B as M&A spree continues

Eli Lilly has splashed up to $3.8 billion on an infectious disease pipeline,

fiercebiotech.com

Ever wondered why malaria in Africa isn't just perennial but also the leading killer of children under age five? Despite the millions of dollars thrown at it, it persists. I did a special edition of the Naked Scientists podcast diving into this question. www.thenakedscientists.com/podcasts/mos...

Malaria in Africa

Why the continent accounts for the overwhelming majority of cases...

thenakedscientists.com

A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines www.nature.com/articles/s41... @lozanzi.bsky.social @harvardmed.bsky.social @natimmunol.nature.com

This is still one of my favorite reviews on the topic of #EbolaVirusDisease. I always revisit whenever there is an outbreak. www.nature.com/articles/s41...

Ebola virus disease - Nature Reviews Disease Primers

Ebola virus disease (EVD) is caused by the filovirus Ebola virus (EBOV). Although the natural host of EBOV is undefined, a single zoonotic transmission is the probable start of most EVD outbreaks. EVD...

nature.com

The WHO discussed the R&D race to advance Bundibugyo virus vaccine candidates. Important to remember that RFK.JR is committed to ending NHP research and the CDC program shuts down this year. Without NHP studies we can't have new drugs or vaccines. www.scientificamerican.com/article/cdc-...

The CDC Is Ending Its Monkey Research Program. Here’s Why That Matters

The Centers for Disease Control and Prevention’s decision to end its monkey research program will affect studies involving some 200 macaques, and the fate of the animals is unclear

scientificamerican.com

A new Lancet study just reported the primary mortality analysis from the RTS,S malaria vaccine implementation programme in Ghana, Kenya, and Malawi. The verdict after 46 months is 1 in 8 deaths averted in eligible children, a very important outcome. www.thelancet.com/journals/lan...

Impact of introducing RTS,S/AS01E malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme

Introduction of the RTS,S malaria vaccine in routine immunisation programmes was associated with a significant reduction in mortality in young children, averting about one in eight deaths, in areas wi...

thelancet.com

New study @insight.jci.org. We investigated NK cell function during acute #malaria and compared with convalescent time-points. The host microenvironment supported increased NK cell activation and cytotoxicity which rapidly reduced after treatment. insight.jci.org/articles/vie... @ki.se #immunosky

So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB #tuberculosis #immunology

Great review from @gpollara.bsky.social et al of role of IL-17 in #MTb – for anyone interested in double-edged sword of cytokine response to mucosal pathogens. Come for the obscure Latin anecdote, stay for the deep dive into contextual consequences of IL-17 activation! bit.ly/4n8oiHv #IDSky #TBSky

Context-specific roles for IL-17 in tuberculosis

The number 17 is considered unlucky by some Italians as its Roman numerals – XVII – can be rearranged as Vixi, a Latin expression that can be interpreted as “my life is over”. In other contexts, the n...

journals.plos.org

In vivo #CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation. From Lesly Calderón @lesly-calderon.bsky.social, Meinrad Busslinger and colleagues: rupress.org/jem/article/... 📘 Part of JEM #Immunology collection 👉 rupress.org/jem/collecti... #AAI2026

IFNγ-induced memory in human #macrophages is sustained by the durability of #cytokine signaling itself. From Aleksandr Gorin, Alexander Hoffmann and colleagues @ucla.edu: rupress.org/jem/article/... 📘 Part of JEM #Immunology collection 👉 rupress.org/jem/collecti... #AAI2026

Parse or 10x? any advice? we're thinking about trying Parse but would love some feedback from the #immunology community. this sequencing project is for lung #macrophages if that matters? please circulate and send me any info about your experiences!! @jeffmold.bsky.social have you used Parse?

#Tuberculosis ! "So TB is back in a big way in the US—10,388 cases last year.... The mix is rough: reactivated latent infections, outbreaks in shelters and prisons, and federal funding getting slashed right when we need it most." crowdbyte.ai/topics/deadl... www.threads.com/@crowd_byte/...

New #IJID editorial: Scientific advances in TB are accelerating, but global impact is not keeping pace. The challenge is no longer innovation—it is implementation. 🔗 Read more: https://ow.ly/3IJS50YzsyM #WorldTBDay #EndTBwithISID #Tuberculosis #ISID

📣Still time to apply! Don’t miss your chance to secure an EFIS–EJI Travel Award! #EarlyCareerResearcher #Immunology

yEFIS@yefis-immunology.bsky.social · 4mo ago

📢 Planning to attend the yEFIS Symposium? Don’t miss the opportunity to apply for the EFIS–EJI Travel Awards! These grants are available to EFIS National Society members – even if they are not currently residing in Europe. 🗓️ Abstract submission deadline: 31 March Submit now 👇 yefis.org/symposium

Link to publications: www.cell.com/immunity/ful... doi.org/10.1016/j.im...

Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies

Variation in antibody genetics, as illustrated in the accompanying paper by Corcoran et al., can present a challenge to the development of population-wide protective vaccines. Fischer, Corcoran, et al...

cell.com

Two new KI studies published in @cp-immunity.bsky.social have mapped immune gene variation across multiple global populations and shown how these variations affect the ability to form neutralising antibodies, for example against the #influenza virus 🧪 #Immunology #Genetics news.ki.se/large-mappin...

Large mapping of hereditary differences in the immune system

Inherited variations in antibody genes can affect how we respond to infections and vaccines, show two new studies from Karolinska Institutet published in the journal Immunity. The researchers have map...

news.ki.se

#HIV overactivates the #immunesystem, causing long-term dysfunction. New research from Linköping University @liu.se shows the #lupus drug #anifrolumab may restore immune cell function, opening the door to immune repair strategies alongside antivirals. #Immunology www.linkedin.com/posts/drmelv...

Structural and genetic basis of #HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies. From Roark, Habib, Shaw, Kwong, Shapiro et al.: rupress.org/jem/article/... 📘 Updates on the Immune Responses to #Tuberculosis & #HIV rupress.org/jem/collecti... #KSTB26 #KSHIVVax26

Yes! We Can End TB. Led by Africa. Powered by People. This #WorldTBDay, we call on African governments to: 🔹 Strengthen people-centred TB services 🔹 Close the funding gap with domestic resources 🔹 Advance regional manufacturing 🔗 Read the letter from GFAN Africa: bit.ly/WTBD-GFANafr... #EndTB

Deconvoluting the interplay of innate & adaptive immunity in BCG-induced nonspecific & #TB-specific host resistance. Perspective by @kerryhilligan.bsky.social et al rupress.org/jem/article/... 📘 Updates on the Immune Responses to #Tuberculosis & #HIV rupress.org/jem/collecti... #KSTB26 #KSHIVVax26

If you work with B cells and clone antibodies or look at BCR sequences, this new study out in @cp-immunity.bsky.social is a must read: www.sciencedirect.com/science/arti... More than 500 allelic variants identified in 25 different Global populations. This matters for biology and SHM calculations!

"This World TB Day, as ever, the world has everything it needs to end tuberculosis in our lifetimes. Yet in 2024, 1·23 million people died of tuberculosis, indicating that tuberculosis persists as the world's deadliest infectious disease" @lancetgh.bsky.social www.thelancet.com/journals/lan...

Tuberculosis at a crossroads

This World Tuberculosis Day, as ever, the world has everything it needs to end tuberculosis in our lifetimes. Yet in 2024, 1·23 million people died of tuberculosis, indicating that tuberculosis persis...

thelancet.com

I'll be speaking at the @yefis-immunology.bsky.social webinar next week. Tune in for some mRNA #tuberculosis vaccine updates.

yEFIS@yefis-immunology.bsky.social · 5mo ago

Join us for a webinar on “Antigenic Mapping & Next-Generation Vaccines in Infectious Disease Research.” 🎤 Dr. Antonia Netzl (University of Cambridge) 🎤 Dr. Louis Ates (BioNTech) 📅 March 24, 2026 ⏰ 3:00 PM CET 🔗 Register: tinyurl.com/yefis2026-ic1

This is wild and crazy-- IgG4 frequently switched Fab arms #Immunosky 🧪 www.nature.com/articles/s41...

Widespread Fab-arm exchange affects all endogenous serum IgG4 - Nature Communications

Among the antibody subclasses, IgG4 is unique in its capability to fragment-antigen-binding (Fab)-arm exchange, a process that renders IgG4 bispecific for antigen binding. Here authors analyse serum I...

nature.com

'After consecutive primary heterosubtypic infections, 4–6% of memory B cells in children are cross-group reactive. These imprinted B cells target the central stalk epitope of HA and exhibit major functional differences.' #Immunology www.nature.com/articles/s41...

B cell imprinting in children impairs antibodies to the haemagglutinin stalk - Nature

Imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes.

nature.com

The immune system in the #uterus can regenerate after uterus or bone marrow transplantation, finds a KI study published in Science Translational Medicine. The new insights may be significant for the treatment of infertility and pregnancy complications 🧪 #Immunology news.ki.se/the-uterus-i...

The uterus' immune system can regenerate after transplantation

The immune system in the uterus can regenerate after both uterus transplantation and bone marrow transplantation. This is shown by a new study from Karolinska Institutet that has been published in the...

news.ki.se