WachtenLab
@wachtenlab.bsky.social
Science and ideas from the lab of Dagmar Wachten
The next #DGZ Focus Workshop on #Cilia & #Centrosomes will take place November 25 (end of October is our DGZ meeting in HD). Join us for a great speaker line-up, and big thanks to David Mick @mick-lab.bsky.social & Dagmar Wachten @wachtenlab.bsky.social for organizing!
Primary #cilia dysfunction as in Bardet-Biedl syndrome compromises normal adipogenic differentiation in favor of fibrogenic transition, predisposing to obesity @wachtenlab.bsky.social and collaborators www.embopress.org/doi/full/10....
🚨 New in The EMBO Journal! Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins. 🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social 📄 www.embopress.org/doi/full/10....
BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue | The EMBO Journal
imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS induces a a cell fa...
embopress.org
🚨 Catching up with great news! Our NAR paper with the @wachtenlab.bsky.social and supported by Prof. Möglich presents a powerful light-switch for gene expression in mammalian cells, with big potential for bioproduction and research. #Optogenetics #SyntheticBiology #Bioproduction #GeneExpression
Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research
Abstract. Precise temporal and spatial control of gene expression greatly benefits the study of specific cellular circuits and activities. Compared to chem
academic.oup.com
💡 Paper alert! We developed DEL-VPR, a potent blue-light photoswitch inducing gene expression in mammalian cells. From basic research to antibody production, this tool offers precise & strong gene control. Teamwork with #Ningaloo academic.oup.com/nar/article/... #SyntheticBiology #Optogenetics
Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research
Abstract. Precise temporal and spatial control of gene expression greatly benefits the study of specific cellular circuits and activities. Compared to chem
academic.oup.com
We are SO EXCITED to share our story @nature.com: 🧵1/ Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring. This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease. 👉 Read here: rdcu.be/erD3b
Kupffer cell programming by maternal obesity triggers fatty liver disease
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
rdcu.be
Looking forward to an inspiring 2-day #iii institute retreat packed with great science, collaborations, and fresh ideas. Grateful to @unibonn.bsky.social for hosting us in #IMPULSE! 🙌🔬
Huge congratulations! 🎉
Universität Bonn@unibonn.bsky.social · last yr.We are excellent! What a day - between hugs, applause and a lot of pride. Our rector? Jumping for joy. Our team? Overjoyed. Thank you to everyone who made this historic moment possible! @dependencybonn.de @immunosens.bsky.social @econtribute.bsky.social © V. Lannert/G. Hübl/Uni Bonn
Thrilled to be part of this amazing journey! 🙌 Hurray indeed! @dfg.de has just approved funding for ImmunoSensation3 🎉 Focused on Immune Diversity, we're set for 7 more years of cutting-edge #immunology in #Bonn! Let’s go! 💥 #ImmunoSensation #science
Cluster of Excellence ImmunoSensation@immunosens.bsky.social · last yr.Hurray! ImmunoSensation will go on! 🥳 The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded! Let us #celebrate 7 more years of #immunology in #Bonn 🎉 www.immunosensation.de/news/immunos...
Proud PI - congratulations to Seniz for being awarded the "Rising Star" award of the @for5547.bsky.social #cilia
FOR5547 Primary cilia dynamics@for5547.bsky.social · last yr.Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia
Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia
🎉 Huge congratulations to Susan Dutcher @dutcherlab.bsky.social on her election to the National Academy of Sciences! A well-deserved recognition of her outstanding contributions to cell biology and cilia research. 👏🔬 #WomenInSTEM #Cilia
WashU Ciliopathy Research Group@wu-ciliopathygroup.bsky.social · last yr.Major congratulations to our fearless leader and team captain Susan Dutcher @dutcherlab.bsky.social for being elected to the National Academy of Sciences! 🙌 Another big win for #cilia biology!!
Excited for an inspiring meeting in France 🇫🇷 on #cilia and #centrosomes! The German #cilia community is en route—let’s connect and share science!
Philippe Bastin's Lab@bastinlab.bsky.social · last yr.Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social Registration is now open www.cfc2025.conferences-pasteur.org
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social Registration is now open www.cfc2025.conferences-pasteur.org
Congratulations to Ronja from the @wachtenlab.bsky.social , who won the 1st poster prize at the international @batenergy.bsky.social meeting! 🎉🥳
Cilia has been at the center of our discussions at the spring school of our @for5547.bsky.social cilia consortium. In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
Interested in primary #cilia, #microtubules, #protein trafficking, molecular #signaling, #GPCRs, and #ciliopathies? We are looking for a #postdoc and a #PhDstudent to apply advanced #biochemistry and #proteomics methods to study cilia. Check out our website and send your application until March 10.
Thanks a lot to #FEBS and the Norwegian bioscience society for hosting me and special thanks to @nathaliejuya.bsky.social and @emreyaksi.bsky.social for your hospitality!
Nathalie Jurisch-Yaksi@nathaliejuya.bsky.social · 2y agoDecoding cilia signaling and function by the one and only @wachtenlab.bsky.social Thanks for delivering a fantastic #FEBS national lecture at the Norwegian bioscience society winter meeting.
Looking forward to #Cilia 2027 - watch out for more information!
Alessandra Boletta@bolettalab.bsky.social · 2y ago🚧 Work in progress for cilia 2027! 🙏 thanks to this amazing group of scientists, clinicians and patient advocates for joining the Cilia 2027 organizing committee! 🌸 Spring 2027 in Milan, more to follow
We would like to welcome you to our second International Conference on Brown and Beige Fat March 31st - April 02nd 2025 Top-class speakers, cutting edge research and respected experts will come together in beautiful Bonn. Registration is open! www.trr333.uni-bonn.de/batenergy-sy...
🗣️We are #hiring! Check out our the latest job opportunities! ▫️ Personnel Administration Expert 📌 Due date: 17/01/2025 ▫️ Flow Cytometry Technician 📌 Due date: 19/01/2025 ▫️ Postdoctoral Fellow in Innate Immune Biology (Dr. Stefanie Wculek) 📌 Due date: 28/02/2025 ➡️ bit.ly/3MR4wO8 🧪
Fantastic team work by our @for5547.bsky.social PIs, headed by David Mick! Check this out: www.biorxiv.org/content/10.1...
iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade
Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...
biorxiv.org
Calendars out- just over two weeks until our 🎉50th🥳 @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium 14/01/2025 15:00-17:30- everything hot in #cilia #centrosomes free & open to all! Register to access this 🔥 series: www.eventbrite.co.uk/e/bscb-genso... /1
Come and visit our #healthybition at #museumkoenig in Bonn! Thanks a lot to everyone who made this possible! @dfgpublic.bsky.social #unibonn #unistiftung and many more!
@sfb1454.bsky.social · 2y agoWhat defines the #WesternLifestyle and how does it impact our health and the planet? 🌍 “What the Health – Eine Welt. Deine Gesundheit!” explores these connections! Visit our #healthybition and the accompanying program 📍 @museumkoenig until 26.10.2025 #unibonn #metaflammation #unistiftung
Many happy faces in our teaching series about #cilia dynamics, connecting the next generation of #cilia researchers within our @for5547.bsky.social and beyond! Thanks a lot, @nathaliejuya.bsky.social for taking the lead!
🚨 Apply now for the ImmunoSensation Postdoc Innovation Funds! We are excited to invite early-career postdocs from the Cluster to apply for funding of up to €10,000 for a 12-month period. The funding period begins on February 1, 2025. Application Deadline: January 10, 2025
Great team effort guys! @wachtenlab.bsky.social @labwilhelm.bsky.social Andreas Schlitzer and all PIs in our @sfb1454.bsky.social
@sfb1454.bsky.social · 2y agoAfter the celebrations of making it into the second funding period, we are now ready for a fresh start in this community - stay tuned for more information about #metaflammation #obesity from our @sfb1454.bsky.social funded by the @dfgpublic.bsky.social www.sfb1454-metaflammation.de
Come and join @babrahaminst.bsky.social Tenure-track and tenured group leader positions in the Immunology Programme babrahaminstitute.livevacancies.co.uk#/job/details...
hireful.
babrahaminstitute.livevacancies.co.uk