Game of microbes: a wildling’s guide

Game of microbes: a wildling’s guide

Laboratory mice housed under specific pathogen-free conditions are the standard model in biomedical research. However, frequent germ-free rederivation and barrier housing restrict microbial exposure and interactions with commensal and pathogenic microorganisms. In contrast, wild mice encounter diverse microbial environments, undergo natural selection, and rely on robust immune responses for survival. Consequently, lifelong microbial exposure is a key driver in shaping mammalian physiology, establishing the need for naturalizing rodent models in biomedical research. By defining the concepts of ‘microbial self’ and ‘microbial nonself’, we propose a four-step guide for establishing a multigenerational wildling colony that accounts for both microbial self and microbial nonself. This reestablishes the common biological link shared by all free-living mammals, thereby improving the comparability between murine and human studies.

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Please share! We hire PIs working in microbiome, metabolism, cancer, allergies, autoimmunity, neurological and infectious diseases. We offer SPF-, gnotobiotic- and wildling-models + generous lab space + top notch equip., e.g. SONY ID7000, 10X Xenium, MACSima. Contact: stephan.rosshart@uk-erlangen.de

Great news—We remain the most successful German University of Excellence! With eight Clusters of Excellence and funding secured until 2033, we’re moving closer to our goal of establishing our Uni permanently among the best universities in the world: www.uni-bonn.de/en/news/040-... © VL/Uni Bonn

Issue 2 is complete! On the cover: Electron micrograph depicting a neonatal hepatocyte densely filled with glycogen (yellow). Nuclei (purple) and mitochondria (red) pseudo-coloured as well. See the Research Article by Nikola Makdissi et al. from @masslab.bsky.social lab: doi.org/10.1242/dev....

Inadequate imposters: Kupffer cells influence liver metabolism This Research Highlight showcases work by Nikola Makdissi, Daria J. Hirschmann, Elvira Mass (@masslab.bsky.social) and colleagues journals.biologists.com/dev/article/...

🧠 #ScienceSnack: The human brain must be able to link memories to their circumstances. Bonn Researchers have discovered two different neuron groups our brain uses to store content and context separately. Findings have been published in @nature.com. www.uni-bonn.de/en/news/004-... © UKB/A. Winkler

Congratulations to Drs. Jose Villadangos and Hamish McWilliam's (@hay-mish.bsky.social) labs on their @science.org paper! Their teams at the Doherty Institute showed that #macrophages are key for MR1 antigen presentation and MAIT cell immunity. 🗒️ https://bit.ly/49W1GW1 🎤 https://bit.ly/44Ay1OG

🚨 Postdoctoral Opportunity for Female Scientists🚨 The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists Interested? Get in touch via direct message careers.univie.ac.at/en/postdoc/e... #MicroSky 🧪 #PostDoc @univie.ac.at

🧬🍽️ Your macrophages may be carrying your mother’s metabolic history! In our @cp-trendsimmuno.bsky.social article, we discuss how maternal diet programs lifelong immune function. authors.elsevier.com/sd/article/S... #ImmuneMemory #Macrophages #MaternalNutrition #DOHaD #EarlyLifeProgramming

Fresh from Elvira Mass Lab @masslab.bsky.social. We are happy to share our thoughts on how maternal malnutrition can shape the development of offspring tissue-resident macrophages during early development. Happy reading!

Trends in Immunology@cp-trendsimmuno.bsky.social · 8mo ago

Maternal diet shapes the development and identity of tissue-resident macrophages #immunology

#Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15. From Frolov, @haohuang0086.bsky.social, Stumm, @masslab.bsky.social, Beyer et al.: rupress.org/jem/article/... 📘 In our #Neuroscience collection: rupress.org/jem/collecti... #SfN25

Happy to have contributed to this beautiful story on #macrophage #development in mice and in #iPSC derived cells. www.science.org/doi/10.1126/... Big congrats to first author Tomi Lazarov for this massive work!!!!👏

Characterization of the mammalian prodefinitive angio-hematopoietic lineage

The identification of mammalian prodefinitive angio-hematopoietic progenitors clarifies early hematopoiesis and macrophage development.

science.org

Interested in #macrophages? Don't forget the check out this Seminar Series 👇

FOR5775 MagNet@for5775.bsky.social · 10mo ago

WE ARE BACK FROM SUMMER BREAK for our next #MagNet #Seminar ⏰Monday, Oct 13th, 4 pm (CET) 🧑‍🔬Thomas Marichal 🗣️“Decoding the lung macrophage landscape: trajectories, niches and functions in health and disease" see poster and webpage for the #zoom link: macrophagenetwork.com/magnet-semin...

The Vienna BioCenter PhD Program application deadline is approaching: October 10! Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology. Apply and start your scientific journey in Vienna! training.vbc.ac.at/phd-program/ #PhD #LifeSciences

Julius Brennecke@juliusbrennecke.bsky.social · 11mo ago

Love RNA biology? Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇). PhD student/postdoc position co-supervised by Clemens Plaschka & myself. DM or email us if you’d like to know more! @vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

🔔PhD position open. Interested in building competencies in computational biology in spatial transcriptomics? Malte Luecken's lab and I have an open PhD position, part of the Munich School of Data Science. Application deadline: Sept 26 Link: www.mu-ds.de

Had the wonderful opportunity to present our data on the effect of microplastics on macrophages at #EMDS2025 ! Such a beautiful venue 🤩 @masslab.bsky.social

Andrew S. MacDonald @profandrewmac.bsky.social · 11mo ago

Fascinating (and disturbing!) presentation about the impact of ingested microplastics on liver macrophages by @mariafviola.bsky.social #EMDS2025

Application is open! Come join us and our fantastic line-up of speakers next year in March in Bonn!

🚨 New in The EMBO Journal! Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins. 🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social 📄 www.embopress.org/doi/full/10....

BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue | The EMBO Journal

imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS induces a a cell fa...

embopress.org

Come be my colleague! We have three open positions at the Assistant/Associate Professor level for candidates in all areas of the biological sciences. www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

imperial.ac.uk

#WomenInSTEM becoming independent: People should feel free to be themselves and do great science. We asked ten women researchers about their science and the process of setting up a lab as an independent researcher: rupress.org/jem/article/...

Out today! www.science.org/doi/10.1126/... From @kknoop.bsky.social & myself on early life immune development & the beautiful publication from Megan Koch & M Shenoy www.science.org/doi/10.1126/... Take home message: timing of early life exposures, milk IgG here, is critical for immune development.

Setting the table for immune tolerance

Interaction between breast milk antibodies and gut microbes shape immune responses during weaning

science.org

This week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover! scim.ag/3UqRrA6

Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience With the great @rebeccalevymdphd.bsky.social

🧠 New book chapter out! We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment. 🔹 Ontogeny & specialization 🔹 Transcriptional & metabolic shifts 🔹 Roles in disease & repair 👉 authors.elsevier.com/a/1lKxcErwXf...

Eliana Franco Taveras@elianafranco.bsky.social · last yr.

Microglia and CNS macrophages are multifaceted cells! We are excited to share our published chapter in Advances in Immunology. If you are curious about where these cells come from and what roles they play; you can access it here: lnkd.in/egqqUYQT Link valid until August 16! @masslab.bsky.social

1/ 💡We are excited to share our latest paper, continuing our exploration of how maternal obesity programs offspring health via #macrophages - this time using #Drosophila as a model: shorturl.at/28tFo #MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology

Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner

Maternal obesity is a growing health concern that predisposes offspring to metabolic dysfunction, immune system alterations, and neurodegenerative dis…

shorturl.at

1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)

The fantastic Menon Lab (@madhvimenon.bsky.social) in the @lydiabeckeriii.bsky.social in Manchester are hiring!! 🚨DO NOT MISS YOUR CHANCE TO APPLY!🚨 www.jobs.manchester.ac.uk/Job/JobDetai... Postdoc seeking to unravel how lung-infiltrating #Bcells contribute to chronic lung disease #immunosky

Research Associate in Mucosal Immunology :Manchester

jobs.manchester.ac.uk

🧪 One month until the application deadline. Get in touch if you are interested ⬇️ #immunosky #cardiosky #academicsky #ecr #studyintheuk

Dr. Anusha Seneviratne@anushans.bsky.social · last yr.

🧪 I am offering projects to study how air pollution affects vascular inflammation as part of Royal Holloway's MSc degree in Biological Sciences research. Contact me if you are interested in applying. www.royalholloway.ac.uk/research-and... #immunosky #cardiosky #idsky #academicsky #academicchatter

We are SO EXCITED to share our story @nature.com: 🧵1/ Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring. This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease. 👉 Read here: rdcu.be/erD3b

Kupffer cell programming by maternal obesity triggers fatty liver disease

Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

rdcu.be

It's time for our next #MagNet #Seminar! It's all about #KupfferCells and #KetogenicDiet presented by Gerasimos Anagnostopoulos via #Zoom ⏰ Monday, June 16th, 4 pm Visit our homepage for more infos: macrophagenetwork.com/magnet-semin...