Lesion network mapping (LNM) links symptoms to brain circuits, but isolating symptom-specific effects remains challenging. We introduce robust LNM, a unified framework to reveal reliable, symptom-specific networks. biorxiv.org/content/10.64898/2026.05.18.725812v2

Association cortex connected to the striatum (esp. prefrontal) is more chained (catenated) than parietal regions belonging to the DMN (e.g. angular gyrus) and context-association network (CAN), with FC to the hippocampus. Why? what's the processing difference? www.biorxiv.org/content/10.6...

Evan Gordon@gordonneuro.bsky.social · 4mo ago

Much of subcortex had strong connectivity specifically to cortical chains. For example, a striatal seed produces connectivity to a single chain, not to a general cortical region. This was true across subcortical structures, suggesting that cortico-subcortical connectivity is organized by chain.

Function & cytoarchitecture don't overlap ... they're orthogonal. Prefrontal cortex is plastered with chains of functional patches previously mostly known from face processing. Why multi-modal parcellations are wrong ... and other insights hidden by group-averaging of fMRI data. great explainer👇🏻

Evan Gordon@gordonneuro.bsky.social · 4mo ago

I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...

I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...

Thrilled to announce our new paper in @natneuro.nature.com! We managed the impossible: precision functional mapping during #DBS, with 11.7h fMRI/patient. Selective DBS-induced deactivations in the SCAN, building on our recent @nature.com paper. nature.com/articles/s41... @ndosenbach.bsky.social

It’s time to rethink Parkinson’s disease. Our work reframes PD as a disorder of the somato-cognitive action network (SCAN), and shows that normalizing SCAN connectivity represents a shared mechanism across diverse effective therapies. rdcu.be/e2n4t @ndosenbach.bsky.social @gordonneuro.bsky.social

A recently discovered brain network that links cognition and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study in Nature. go.nature.com/49VBuKI #Neuroskyence 🧪

A recently discovered brain network that links cognition (thinking) and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study published in Nature: spklr.io/63320DMwOi #Neuroscience #Neuroskyence #Parkinsons 🧠 🧪

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

spklr.io

Game-changer for PD therapy! Our @Nature study shows targeting the SCAN network with non-invasive brain stimulation doubles efficacy—no surgery needed. #Therapy #BrainScience #HealthTech nature.com/articles/s41...

Nature research paper: Parkinson’s disease as a somato-cognitive action network disorder go.nature.com/4aemciV

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

go.nature.com

The highlight of my week was the publication of "Parkinson’s disease as a somato-cognitive action network disorder" in @nature.com. It's a great paper that shows how conceptual changes in fundamental neuroscience - the discovery of SCAN - can improve treatment 🧪 www.nature.com/articles/s41...

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

nature.com

Breakthrough @nature.com study showcases new non-invasive treatment for Parkinson’s Disease that targets the somato-cognitive action network (SCAN) with personalized neuromodulation, for superior outcomes. www.nature.com/articles/s41...

Evan Gordon@gordonneuro.bsky.social · 6mo ago

I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment. www.nature.com/articles/s41...

#Medsky🧪 #IDsky #Neurosky #publichealth @nature.com This study has redefined #ParkinsonsDisease (PD) as a disorder of the Somato-Cognitive Action Network (SCAN), a brain system that integrates whole-body movement, cognition, and internal physiological states www.nature.com/articles/s41...

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

nature.com

A recently discovered brain network that links cognition and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study in Nature. go.nature.com/49VBuKI #Neuroskyence 🧪

More excellent reporting by NPR's Jon Hamilton about a new brain network that explains symptoms of Parkinson's that have befuddled brain researchers for decades. Kudos to @jianxunren.bsky.social and Hesheng Liu for this groundbreaking research in the journal Nature! doi.org/10.1038/s415...

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

doi.org

In case this important point gets overlooked: along with our Nature paper, we’ve publicly released two large and scarce datasets—PIPD and PIET. IMHO, these are the best open Parkinson's and Tremor datasets available to date. See threads (1/4) 👇 nature.com/articles/s41...

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

nature.com

Don’t miss out reading about this amazing work linking the SCAN to Parkinson’s disease. What are the best ways we could use this new knowledge?!

Nico Dosenbach@ndosenbach.bsky.social · 6mo ago

Breakthrough @nature.com study showcases new non-invasive treatment for Parkinson’s Disease that targets the somato-cognitive action network (SCAN) with personalized neuromodulation, for superior outcomes. www.nature.com/articles/s41...

Researchers propose that the somato-cognitive action network (SCAN) "hyperconnectivity is central to PD pathophysiology & its alleviation is a hallmark of successful neuromodulation"; #Parkinsons as a somato-cognitive action network disorder www.nature.com/articles/s41...

Ren, J., Zhang, W., Dahmani, L. et al. Parkinson’s disease as a somato-cognitive action network disorder. Nature (2026). doi.org/10.1038/s415...

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

doi.org

This is a nice animation illustrating the key points in the Parkinson's SCAN paper about which I posted previously.

Jianxun Ren@jianxunren.bsky.social · 6mo ago

Happy to share a short but super cool video that gives a quick overview of our Nature paper on the somato-cognitive action of netwokr in Parkinson's disease www.nature.com/articles/s41...

Good news for Parkinson's sufferers. These researchers should review recent papers on Essential Tremor. ET researchers have identified the back of the brain as the ET problem area, the same area identified as part of the Parkinson's problem. Potential for beneficial cooperation. (I have ET.)

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

nature.com

Such a fascinating paper! Less than 3 years after the discovery of the new motor network (SCAN) interleaved between effector motor regions, SCAN is proving highly relevant for Parkinson’s! It offers potential to improve treatment and reduce symptoms non-invasively.

Jianxun Ren@jianxunren.bsky.social · 6mo ago

Happy to share a short but super cool video that gives a quick overview of our Nature paper on the somato-cognitive action of netwokr in Parkinson's disease www.nature.com/articles/s41...

Fantastic work showint how SCAN is related to Parkinson’s disease. Much promise for the future of battling the disease! www.nature.com/articles/s41...

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

nature.com

Washington University researchers scanned 863 patients and found that Parkinson’s is not just a motor disorder. It stems from hyperactivity in the brain’s somato-cognitive action network, and treatments work best when they calm this network. www.nature.com/articles/s41...

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

nature.com

Parkinson’s disease has the fastest-growing prevalence of any neurodegenerative disorder worldwide go.nature.com/4r0xZsk

Immune cells from the gut drive development of Parkinson’s disease in the brain

In ‘body-first’ Parkinson’s disease, misfolded proteins propagate from the gut’s nervous system to the brain. Immune-cell activity seems to play a key part in this spread.

go.nature.com

Really cool attempt to link together multiple neuromodulation methods (DBS, TMS, TUS) to understand the neural basis of Parkinson's disease.

Nature Portfolio@natureportfolio.nature.com · 6mo ago

A recently discovered brain network that links cognition and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study in Nature. go.nature.com/49VBuKI #Neuroskyence 🧪

Non-invasive brain surface stimulation targeting personalized SCAN alleviated symptoms in patients with Parkinson’s disease. See the videos below.(www.nature.com/articles/s41...)

Jianxun Ren@jianxunren.bsky.social · 6mo ago

It’s time to rethink Parkinson’s disease. Our work reframes PD as a disorder of the somato-cognitive action network (SCAN), and shows that normalizing SCAN connectivity represents a shared mechanism across diverse effective therapies. rdcu.be/e2n4t @ndosenbach.bsky.social @gordonneuro.bsky.social

www.nature.com/articles/s41... the original research article ... no paywall

Parkinson’s disease as a somato-cognitive action network disorder - Nature

The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.

nature.com

Happy to share a short but super cool video that gives a quick overview of our Nature paper on the somato-cognitive action of netwokr in Parkinson's disease www.nature.com/articles/s41...

I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment. www.nature.com/articles/s41...