I had to physically print and submit 3 paper copies of my PhD thesis. I had to print and post multiple copies of my first fellowship applications. But even this volume of wasted paper is nothing compared to small children’s crafts and drawings

We are pleased that our article on Ataxin-2 and the integrated stress response in C9orf72 ALS/FTD is finally published in full. A lot of hard work from members of the lab, including @comeflywithjo.bsky.social, and our collaborators link.springer.com/article/10.1...

Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis - Acta Neuropathologi...

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal, early-onset neurodegenerative diseases. The most common genetic cause of FTD and ALS is a G4C2 hexanucleotide repeat ex...

link.springer.com

Moody skies over Sheffield from the office window this morning

Somewhat depleted in numbers due to illnesses half the lab made it out for our annual, rather wet, lab winter walk

I'm looking forward to discussing our work at Tambourine’s ALS Breakthrough Research Fund investigators meeting this week. A pretty good view from my room

taking a break from all the hills and letting the 5 yo loose down the monsal trail

Scott Allen and myself have an opportunity for a postdoc working on pyruvate metabolism in normoxia and hypoxia using a combination of C9orf72 patient-derived iNPC and Drosophila models. Based at SITraN (sheffield.ac.uk/sitran) jobsite.sheffield.ac.uk/job/Research...

Check out our new #neuroscience @BiologyatYork banner to showcase our diverse, multidisciplinary, multi model, and so much fun research environment that you could be in by joining us as an under or postgrad york.ac.uk/study/undergra… or/and postgrad too!

🚀 Hot off the press! Our team findings @livuni-ismib.bsky.social on brain ageing unveil a novel connection between oxidative stress, neuronal microtubules, and the cytoskeletal protein EB1 driving neuronal atrophy. 🎉 A huge thank you to the fantastic team! www.aginganddisease.org/EN/10.14336/...

oh ChatGPT what monstrosity is this?

There are some hills over there somewhere!

Clear skies over SITraN this morning

I think santa will enjoy the whisky the 4 year old left for him 👀

a slightly chilly lab walk in the peaks

A birthday card from the lab. A @comeflywithjo.bsky.social special. I wonder what they are trying to imply?

Poster session B, 5.30-7 7th December

Ryan West@westwingslab.bsky.social · 2y ago

For anyone heading to #alsmndsymp in montreal look out for @mndassoc.bsky.social funded student Charlotte Gale-Rogers work on C9orf72 DPR disruption to locomotor rhythmicity using some of our fly models. Poster IVV-26.

I am pleased we were able to help with this nice paper showing RuvBL1/2 can reduce DPR abundance and reduce phenotypes observed in our fly models www.life-science-alliance.org/content/8/2/...

RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD

A G4C2 hexanucleotide repeat expansion in C9orf72 is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). Bidirectional transcription and subsequent repeat-a...

life-science-alliance.org

For anyone heading to #alsmndsymp in montreal look out for @mndassoc.bsky.social funded student Charlotte Gale-Rogers work on C9orf72 DPR disruption to locomotor rhythmicity using some of our fly models. Poster IVV-26.

striking views from my office this morning

twitter account deactivated. It's bluesky only now

Google scholar vs pubmed wordclouds

🧠Sharing this Starter Pack again as the list has now reached 80 people! A great mix of Profs/PIs/Post-docs/PhDs/Technicians. Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋 go.bsky.app/S6FfsTp

a quick trip down to London for a grant panel and to say hello to some old friends

back from a very enjoyable @nc3rs.bsky.social Partnership and Impact panel meeting. Lots of great science. Looking forward to seeing some of those projects going forward.

Green, M. M. (2010) 2010: A century of #Drosophila genetics through the prism of the 'white' gene. Genetics 184, 3-7 — www.ncbi.nlm.nih.gov/pubmed/20061...

2010: A century of Drosophila genetics through the prism of the white gene - PubMed

In January 1910, a century ago, Thomas Hunt Morgan discovered his first Drosophila mutant, a white-eyed male (Morgan 1910). Morgan named the mutant gene white and soon demonstrated that it resided on ...

ncbi.nlm.nih.gov

LaurierBiology@laurierbiology.bsky.social · 2y ago

Wishing all the fly-pushers a wonderful #DrosophilaDay/#FlyDay as we celebrate the anniversary (11/18) of the #Drosophila white-eyes mutant line w1118!

a quick trip down to London for a grant panel and to say hello to some old friends

Trying for a molecular and cellular neurobiology starter pack - happy to add folks and connect :) #neuroskyance #cellbiology go.bsky.app/PgEk7aF

As PIs we can mentor our team to select colorblind friendly pseudo colors at acquisition time 🔬and share free (and super cool) resources like colororacle.org and medialab.github.io/iwanthue/ that helps you select or design color friendly palettes for projects that have many categories 💻 #dataViz

MadScientist@mads100tist.bsky.social · 2y ago

Reminder for scientist: don't use red+green LUTs. Make your images and videos colorblind friendly. Run them through one of many tools available to make them accessible 🧪 #microscopy

If you're not sure which Starter Packs you've been added to, you can check them on clearsky.app That's where I found the ones that I'm part of. Wish we could get notified when added to a pack @bsky.app ?

My starter pack is growing! Please reach out if you use animal models (flies, worms, mice, fish, etc) to study disease mechanisms and want to be added. go.bsky.app/MhUwjSx