Ali Twelvetrees

@dozenoaks.bsky.social

Sir Henry Dale Fellow | Sheffield | cell & molecular neurobiology | kinesin, dynein, slow transport and neurodegeneration | preferably one molecule at a time | my opinions | she/her

Almost exactly 6 months ago, RPN was leaked a document presented to STFC staff that said the council had to reduce spending by £162m by 2029-30 That kicked off months of debate on how cuts would be made But only now has it become clear the total cost savings needed over 4 years is in fact £684m 🧵

Absolutely beautiful work from the Bradke lab here. As an aside, I'm also genuinely stunned to see fundamental neuronal cell biology like this in Nature! An intrinsic cytoskeletal oscillator establishes neuronal polarityhttps://www.nature.com/articles/s41586-026-10755-6

An intrinsic cytoskeletal oscillator establishes neuronal polarity - Nature

The ARP2/3 complex works together with actomyosin in an oscillatory program at the soma to govern neuronal polarization.

nature.com

🚨 Early bird registration deadline for NeuroBioUK26 is fast approaching! Register by July 17th to secure your discounted rate (£35) AND remember to submit your abstract to be in the running for a talk slot. You're faithful organising committee have some hard deadlines this year, so please submit!

NeuroBioUK - Registration

Step 1: Register through our event page. All attendees should register to attend through our event page. Early bird registration deadline is the 17th of July (£35) and late registration deadline is th...

neurobiouk.sites.sheffield.ac.uk

🚨 Early bird registration deadline for NeuroBioUK26 is fast approaching! Register by July 17th to secure your discounted rate (£35) AND remember to submit your abstract to be in the running for a talk slot. You're faithful organising committee have some hard deadlines this year, so please submit!

NeuroBioUK - Registration

Step 1: Register through our event page. All attendees should register to attend through our event page. Early bird registration deadline is the 17th of July (£35) and late registration deadline is th...

neurobiouk.sites.sheffield.ac.uk

For 6 months the line from DSIT & UKRI on STFC cuts has been that no final decisions have been taken That is no longer the case, after DSIT approved UKRI's proposal for how to save £162m British research at Cern will be hit, along with UK science facilities Scoop by me & @francesjones.bsky.social

UK research at Cern to shrink as government approves STFC cuts - Research Professional News

Exclusive: Science department approves UKRI’s cost-saving proposal, with major UK facilities also facing cutbacks

researchprofessionalnews.com

This is really rough news for everyone who works at RP. I'm so sorry to read this and hope impacted colleagues have good support networks to lean on. It will create a huge hole in a sector for which the timing couldn't be worse. www.researchprofessionalnews.com/rr-news-uk-o...

Research Professional News to discontinue publication at end of 2026 - Research Professional News

A message for readers about the publication’s closure and continued community access to past reporting

researchprofessionalnews.com

I looked at this but left it out of the post, because the gender inference tool could only classify 44% of first authors and 31% of last authors. But given this caveat, this is the distribution: First authors: 71% male, 29% female Last authors: 83% male, 17% female

As you might imagine, as someone who studies science and works on metrics, I have some thoughts on qed myself. I fully agree that the messaging can be described as tone-deaf and problematic. I don’t think it had to be. ripplingideas.org/2026/06/26/t...

The 1% club and the rocky road ahead for bioRxiv

The recent launch of qed’s “top 1%” preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. Whil…

ripplingideas.org

Noticeable underrepresentation of women as corresponding authors in the 1%. Almost as if AI has been trained on years of discriminatory behaviours and is perpetuating that bias.

🐮 What lies between the “spherical cow” of purified proteins and live-cell imaging? The messy middle. Explore single-molecule biophysics in crude lysates and serum, with real-world case studies and practical workflows. excitinginstruments.com/resource-lib... #biophysics #singlemolecule

Embracing biophysics in cell lysates or serum | Exciting Instruments

Explore how the 'messy middle' of biophysics, namely cell lysates and serum, combines single-molecule sensitivity with biological context.

excitinginstruments.com

Gutted not to be at the Cell Biology of the Neuron GRC this week - please do check out Emma Turner’s poster if you’re there. The next part of our kinesin-1 odyssey will be a preprint soon, but you can get a sneak peek this week :)

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Patrick Vallance has twice written to MPs saying the budget for curiosity-driven research “will grow as the economy grows” But UKRI has flat cash for curiosity-led research through to 2030 When @isaacbarbosa1.bsky.social asked DSIT where the growth would come from, they had no answer A mystery

Research Professional News@resprofnews.bsky.social · 3mo ago

Dsit unable to explain Vallance claim on curiosity-led growth. www.researchprofessionalnews.com/rr-news-uk-p...