Very happy to see this #MechanoGolgi story out (and in full open access, thanks to @upf.edu). Thanks a lot to everyone who contributed and helped make this possible, and, hopefully, more to come! rupress.org/jcb/article/...

Felix Campelo@felixmendu.bsky.social · 11mo ago

🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.6... Layered helical order reveals assembly states in podosome actin networks

www.sciencedirect.com/science/arti... The actin crosslinker Fimbrin is required for force sensing at tricellular junctions

Legendary myosin researcher Jim Sellers retires after many years of making significant contributions to the field and being an unfailingly generous to colleagues - alway sharing materials, insights and wisdom. A symposium honoring Jim will be held in Sept. www.nhlbi.nih.gov/events/2026/...

Scientific Symposium Honoring Dr. James R. Sellers

Retirement symposium honoring Dr. James R. Sellers’ contributions to myosin studies. Leading scientists in the field will be present.

nhlbi.nih.gov

www.nature.com/articles/s41...

Leiomodin 2 is a processive pointed-end elongator of actin filaments - Nature Communications

This study identifies the cardiac protein Leiomodin 2 as an actin filament polymerase that enables growth from filament pointed ends, revealing how muscle actin filament length is controlled and how L...

nature.com

Feedback between filament spacing, crosslinker binding, and self-organization in cytoskeletal bundles www.biorxiv.org/content/10.6...

CryoSPARC workshop in Toronto! Beyond consensus refinements: Advanced cryo-EM data processing with CryoSPARC Sept 24-25, 2026 (part of the Canadian Cryo-EM Nexus) Register here: cvent.me/dL1wem Please see details in the link or the image Alt text @structurabio.bsky.social @sickkidsto.bsky.social

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...

1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...

Happy to share our new review of structural and biophysical mechanisms of cytoskeletal force transduction: doi.org/10.1146/annu...

Structural Biophysics of Cytoskeletal Force Transduction

Cells mechanically interface with their surroundings through the actin cytoskeleton, a network of dynamic actin filaments, force-generating myosin motor proteins, and hundreds of associated binding pr...

doi.org

⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece.

Roberto Vázquez Núñez@robertovn.bsky.social · 2mo ago

🚨 New preprint: GATO-seq did it again! ELOF1 is the missing promoter-proximal factor that confers RNA Pol II resistance to TFIIF. Including ELOF1, DSIF, and NELF in GATO-seq reactions recapitulates promoter-proximal pausing in vitro at physiological conditions for the 1st time. tinyurl.com/ELOF1

I heard from several sources yesterday that NIH is planning to release a Request for Information (RFI) that apparently will include this: Scores and percentiles for NIH grant applications will not be shared with applicants although they will be provided to NIH program officers and staff. 1/3

Huh Kermit

ALT: Huh Kermit

static.klipy.com

Spotlight: New work by Zheng et al. (rupress.org/jcb/article/...) elucidates how #adhesion proteins are rapidly moved along the cell edge to vertices in response to mechanical forces. Jiarui Jiang and @krothphd.bsky.social discuss the findings: rupress.org/jcb/article/... #Mechanobiology

Excited to highlight some exciting findings from our recent paper that uncovers how an unusual molecular motor, Myosin F, powers actin dynamics in Toxoplasma gondii. journals.biologists.com/jcs/article/...

Molecular features of myosin F adapted for driving actin flows in Toxoplasma gondii

Highlighted Article: MyoF regulates actin organization in T. gondii by assembling into an oligomeric complex that contains multiple motor domains.

journals.biologists.com

Easymode: general pretrained networks for cellular cryo-ET enable flexible approaches to subtomogram averaging www.biorxiv.org/content/10.64898/2026.05.19.726344v1 #cryoEM

www.annualreviews.org/content/jour...

Structural Biophysics of Cytoskeletal Force Transduction

Cells mechanically interface with their surroundings through the actin cytoskeleton, a network of dynamic actin filaments, force-generating myosin motor proteins, and hundreds of associated binding pr...

annualreviews.org

onlinelibrary.wiley.com/doi/10.1002/... "Dr. Pollard reflects on key discoveries that shaped the actin field and on the role of quantitative thinking in biology."

Foundational Discoveries in Actin Regulation: An Interview With Tom Pollard

Dr. Thomas D. Pollard's work transformed cytoskeleton research into a quantitative, mechanistic science. Over five decades, he established core principles of actin dynamics, including filament polari...

onlinelibrary.wiley.com

BioID with actin and tubulin! Proteomic profiling of cytoskeletal interactomes using MT-ID and Act-ID www.biorxiv.org/content/10.6...

Please share widely. The new (simpler) MIRA R35 for Early Stage Investigators (ESI) NOFO is published. First due date is 10/2/2026. files.simpler.grants.gov/opportunitie...

Please check out our new preprint! Together with @sarathomasy.bsky.social and led by DVM/PhD candidate Raneesh Ramarapu, we used 3D imaging + quantitative analysis to show how the corneal endothelium maintains a stable layer and refines hexagonal packing during development.

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 3mo ago

Quantitative imaging of corneal endothelial development reveals dynamic but resilient monolayer https://www.biorxiv.org/content/10.64898/2026.05.01.722310v1

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

FANTASTIC work from @myosincity.bsky.social and @pwoakes.bsky.social on smooth muscle myosin II filament dynamics! Vascular Smooth Muscle Myosin 2 Filaments Dynamically Assemble and Stabilize During Induced Contractility www.biorxiv.org/content/10.1...

It is with great sadness that we announce J. Craig Venter has died. 🧪🧬 www.jcvi.org/media-center...

J. Craig Venter, genomics pioneer and founder of JCVI and Diploid Genomics, Inc., dies at 79

La Jolla, California—April 29, 2026—The J. Craig Venter Institute (JCVI) announced that J. Craig Venter, Ph.D., the Institute’s founder, board...

jcvi.org

Jeanne Garbarino, head of RockEDU Science Outreach at Rockefeller, says that persistence in #STEM depends on fostering a culture of high-quality mentoring and long-term engagement. “Students stay in STEM when they feel like they belong.” 🔗: https://bit.ly/424DrQd

Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

Excited so share our theoretical work on cryo-EM vitrification and recovering ensemble distributions!!

Miro Astore@miroastore.bsky.social · 3mo ago

We just preprinted one of my favorite studies @FlatironInst . I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...

Nature research paper: Myosin forces remodel F-actin for mechanosensitive protein recognition go.nature.com/4sTeWAq

Myosin forces remodel F-actin for mechanosensitive protein recognition - Nature

Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and intercellular communication via adhesion complexes.

go.nature.com

How do cells convert mechanical information into a molecular process? The @alushinlab.bsky.social has captured the first snapshot of a mechanical signaling complex in action, findings in @nature.com that have implications for disorders related to myosin dysfunction. 🔗: https://bit.ly/41Kshjw

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com : www.nature.com/articles/s41...