Our hedgehog coronavirus receptor study is now out in Nature Microbiology! Exciting new data has been added since the pre-print, including structure-guided mutagenesis showing species barriers, TMPRSS2 experiments and more details on the curious temperature adaptation in hedgehogs. (1/4)

ASV is alarmed by the US HHS to suspend and debar Dr. Ralph Baric from federal funding. Read our open letter below:

www.science.org/content/arti...

Virologist accused of starting COVID-19 will fight U.S. ban on funding

HHS memo says Ralph Baric had a “pattern of deception” in describing virus studies long before pandemic

science.org

Now online! High-resolution in situ structures of hantavirus glycoprotein tetramers

High-resolution in situ structures of hantavirus glycoprotein tetramers

The cryo-EM structures of Andes hantavirus (ANDV) glycoprotein tetramers, dimers of tetramers, and ADI-65534 Fab complexes on eVLPs unveil the molecular basis of New World hantavirus glycoprotein architecture, acid-induced membrane fusion, and antibody-mediated neutralization. Immunization with repRNA encoding ANDV-VLPs elicits high neutralizing-antibody titers.

dlvr.it

It's really real 😭😭😭 Huge thanks to Wrapper's Delight ( @wrapplab.bsky.social ) and T-Pain ( @timothysheahan.bsky.social ) for everything. Working on this together was the best part of 2025!

Tim Sheahan@timothysheahan.bsky.social · 9mo ago

Human coronavirus 229E antibodies and Spike structure function paper is finally out for real. Led by @wrapplab.bsky.social (wrappers delight) and @mlicc1701.bsky.social (MFL) #lovevirology #229E #antibodies www.nature.com/articles/s42...

Human coronavirus 229E antibodies and Spike structure function paper is finally out for real. Led by @wrapplab.bsky.social (wrappers delight) and @mlicc1701.bsky.social (MFL) #lovevirology #229E #antibodies www.nature.com/articles/s42...

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain www.nature.com/articles/s42... @wrapplab.bsky.social

Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...

Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice

HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.

science.org

I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow

Texas Science@texasscience.bsky.social · 12mo ago

UT Austin has a new “genius grant” recipient! Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation. #TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social cns.utexas.edu/news/accolad...

As part of our 2025 “Rising Stars in #Vaccinology and #Immunity to #Microbes” seminar series, we spoke with Dr. Daniel Wrapp @wrapplab.bsky.social who uses structure-based design to develop new #antiviral therapies. cvimp.podbean.com/e/episode-13...

Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen www.biorxiv.org/content/10.1101/2025.05.19.654955v1 #cryoEM

Very excited to share our latest preprint describing the isolation and characterization of neutralizing HCoV-229E-directed antibodies from a human donor! Great collaboration between DHVI and the Baric and Sheahan (@timothysheahan.bsky.social) labs at UNC. www.biorxiv.org/content/10.1...

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

HCoV-229E is an endemic Alphacoronavirus that typically causes common cold-like disease in most healthy adults, but can also cause severe respiratory disease in the very young and the elderly. Althoug...

biorxiv.org