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Matt Slein

@mattslein.bsky.social

Postdoctoral Fellow in the McLellan Lab at the University of Texas at Austin

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Nature Reviews Microbiology@natrevmicro.nature.com · 5mo ago

New online! Human herpesvirus evasion of humoral immunity and implications for vaccine development

Human herpesvirus evasion of humoral immunity and implications for vaccine development

Nature Reviews Microbiology, Published online: 13 March 2026; doi:10.1038/s41579-026-01295-xIn this Review, Otero et al. explore how human herpesviruses evade humoral immune responses and consider the resulting implications for developing effective vaccines and treatments for diseases caused by these common viral pathogens.

dlvr.it

Matt Slein@mattslein.bsky.social · 5mo ago

The final portion of my PhD thesis is now live! Here we describe that both neutralziing and non neutralizing Abs targeting HSV gB require Fc effector functions to protect neonatal mice from infection. Thanks to all my coauthors, collaborators and thesis advisors! journals.asm.org/doi/10.1128/...

Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice | Journal of Virology

Antibodies represent promising drugs for the prevention and treatment of viral infections, especially when efficacious vaccines are unavailable. Determining the dominant mechanisms of Ab-mediated prot...

journals.asm.org

Matt Slein@mattslein.bsky.social · 9mo ago

Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...

Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice

HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.

science.org

Jason McLellan@mclellanlab.bsky.social · 10mo ago

I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow

Texas Science@texasscience.bsky.social · 10mo ago

UT Austin has a new “genius grant” recipient! Texas Science professor Jason McLellan has been awarded a MacArthur Fellowship — aka the “genius grant” — by The MacArthur Foundation. #TexasScience @mclellanlab.bsky.social #MacArthurGenius @utaustin.bsky.social cns.utexas.edu/news/accolad...

Matt Slein@mattslein.bsky.social · 10mo ago

Excited to have contributed to Volume 12 of Annual Review of Virology! www.annualreviews.org/content/jour...

Maternal Antibodies to Neurovirulent Pathogens in Fetal Tissues

Infection by neurovirulent pathogens in utero and during the neonatal period can lead to fetal and neonatal mortality as well as neurological morbidity with lifelong consequences. Fortunately, materna...

annualreviews.org

Annual Reviews@annualreviews.bsky.social · 10mo ago

💉 The most recent Annual Review of Virology is now online. Most read article so far is "In Transition: How Influenza Virus Switches from Transcription to Genome Replication" by Tao Deng et al. arevie.ws/42kxUFU For full TOC: arevie.ws/3IDG4Cz

Matt Slein@mattslein.bsky.social · last yr.

Excited to share a portion of my PhD work describing the mechanisms of antibody-mediated protection against HSV infection. Here we show that a panel of 5 mAbs targeting gB all required Fc effector functions to be protective in a mouse model of neonatal HSV infection. www.biorxiv.org/content/10.1...

Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice

Glycoprotein B (gB) serves as the viral fusion protein for herpes simplex virus (HSV), mediating fusion between viral and host membranes resulting in infection. As such, gB represents a potentially cr...

biorxiv.org

David R. Martinez@davidmartinez.bsky.social · last yr.

A paper from our pancoronavirus vaccine P01 grant group is now out in Science Translational Medicine. Here we show that non-stabilized spike delivered as mRNA is sufficient to elicit broadly neutralizing antibodies in monkeys. @alexschaefer.bsky.social www.science.org/doi/10.1126/...

Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates

Nonstabilized SARS-CoV-2 spike mRNA vaccination elicited distinct antibodies to either Omicron variants of concern or preemergent sarbecoviruses.

science.org

Matt Slein@mattslein.bsky.social · last yr.

A review I wrote for the upcoming issue of Annual Review of Virology is now live as a Review in Advance! tinyurl.com/ARV2025 Here we talk about the multifaceted role of maternal antibodies in protection against three important congenital viral infections. #virology

Maternal Antibodies to Neurovirulent Pathogens in Fetal Tissues | Annual Reviews

Infection by neurovirulent pathogens in utero and during the neonatal period can lead to fetal and neonatal mortality as well as neurological morbidity with lifelong consequences. Fortunately, materna...

tinyurl.com