Roughly half of common disease heritability is pleiotropic across diseases, with shared variance 1.51x enriched in the genetic component. Work led by Yujie Zhao (co-supervised by Alkes and me) is now out in @natgenet.nature.com www.nature.com/articles/s41...

Huge congrats to @xilinjiang.bsky.social (Wellcome fellow in the group) on his first senior author paper, in @natgenet.nature.com no less! 👏👏👏👏 Pleiotropic shared heritability quantifies the shared genetic variance of common diseases www.nature.com/articles/s41...

Pleiotropic shared heritability quantifies the shared genetic variance of common diseases - Nature Genetics

Pleiotropic shared heritability with bias correction (PHBC) estimates the genetic variance of a target disease that is shared with a set of auxiliary diseases. Applying PHBC to diseases in the UK Biob...

nature.com

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

medrxiv.org