Congratulations to Devin Clegg from the Ferguson Lab on his work determining how PIKfyve inhibition leads to LRRK2 activation at lysosomes! @shawnferguson.bsky.social
Journal of Cell Biology@jcb.org · 4d agoClegg, @shawnferguson.bsky.social et al. @yalecellbiology.bsky.social show that LRRK2 integrates distinct lysosomal stress signals through stimulus-specific combinations of interactions with Rab GTPases and GABARAP. rupress.org/jcb/article/... #Lysosomes #CellSignaling #Disease #Organelles
In @jcb.org, Clegg, @shawnferguson.bsky.social et al. @yalecellbiology.bsky.social show that LRRK2 integrates distinct lysosomal stress signals through stimulus-specific combinations of interactions with Rab GTPases and GABARAP. rupress.org/jcb/article/... #Lysosomes #CellSignaling #Disease
Another Cell Bio Spotlights article! Here, Linnea Hartz features Xinbo Wang from the De Camilli Lab and his work on BLTPs during lysosome repair. Check it out! @xinbowang.bsky.social @pdc-lab.bsky.social medicine.yale.edu/cellbio/news...
The Last Straw for Lysosome Repair with Dr. Xinbo Wang.
Imagine that you have just been handed a boba tea and a straw, pictured to the right. To enjoy your drink, you must first puncture the lid with the pointed end
medicine.yale.edu
Check out the recent Cell Bio Spotlights article by Sandra Sandria highlighting XJ Xu and Chee San Tong from the Wu Lab and their work on the dynamics of phosphoinositides! @wumin-lab.bsky.social medicine.yale.edu/cellbio/news...
Unraveling the Mysteries of Signaling Lipids with the Wu Lab
The cell’s plasma membrane serves as a barrier between the interior contents of the cell and its external environment; put simply, it keeps the good stuff in
medicine.yale.edu
Hesitating to apply? #GilliamFellow Tyreek Jenkins can relate. Smaller institution, in a small lab, "You're always facing the imposture syndrome. But if you're passionate about your research … that's enough." 2nd-/3rd-year PhD students: Apps open 9/1 for our biggest cohort yet! bit.ly/gilliam26
Two new articles from the Reinisch lab @yalecellbiology.bsky.social and De Camilli lab @yaleneuro.bsky.social provide the first complete molecular characterization of VPS13A and C, two proteins involved in neurodegenerative diseases, and show that they can exist in active and inactive states.
New Insights into Proteins Linked to Neurodegeneration
Mutations in VPS13 proteins are associated with neurodegenerative conditions like Parkinson’s disease. New findings could point to therapeutic avenues.
medicine.yale.edu
Public comments are due today, July 13, by 11:59 p.m. ET. ➡️ Review this guide for an outline of key provisions and practical tips for participating in the process: www.asbmb.org/advocacy/omb.... #ScienceServesUsAll #ASBMBAdvocates
OMB proposed rule could reshape federal research funding
asbmb.org
American Society for Biochemistry and Molecular Biology@asbmb.bsky.social · 4mo ago⏰July 13 deadline: Proposed OMB research funding rule comments OMB has proposed major changes to the rules governing federal research grants: www.asbmb.org/asbmb-today/.... 📝Review practical tips for participating in the process: www.asbmb.org/advocacy/omb... #ScienceServesUsAll #ASBMBAdvocates
Congratulations to @dazhi-li.bsky.social and members of the Reinisch and De Camilli groups @pdc-lab.bsky.social on their recent work on the structure of Bridge-like lipid transfer protein VPS13C!
Dazhi Li@dazhi-li.bsky.social · 4mo agoExcited to see this study, in collaboration with the De Camilli group @pdc-lab.bsky.social, published in its final format! We resolved the structure of VPS13C and found that it adopts a lipid-transfer-incompetent conformation. We also show that CaM binds VPS13s and may help regulate their function.
Who are the trainees at Yale Cell Biology and what are they working on? Check out our first Cell Biology Spotlights article to learn about Dr. Kimberly Morgan, a postdoc in the LusKing Lab @luskinglab.bsky.social , and her work imaging Nuclear Pore Complexes! (1/2) medicine.yale.edu/cellbio/news...
Cell Biology Spotlights: Picturing Nuclear Pore Complexes in a New Light with Dr. Kimberly Morgan
A picture is worth 1,000 words, and this holds true for the plethora of information researchers can obtain from pictures of our cells. The constant processes
medicine.yale.edu
hi everybody, asmita here back at it again with another preprint for your attention. excited to share our new fluorogenic speed probes that enable whole cell 3D imaging! 🔬
Florian Schueder@florianschueder.bsky.social · 7mo agoPlease check out our newest work on fluorogenic speed imager probes, in which we combine the strengths of speed-optimized imagers and fluorogenic imagers. #SuperResolution #DNAPAINT #microscopy www.biorxiv.org/content/10.6...
Interested in the nuclear envelope? Do you reside in the US northeast (or are willing to pay a visit)? Don't miss this year's NENE (northeast nuclear envelope) - a trainee-led regional meeting that brings together scientists at all levels for a day of exciting talks and discussions. June 5th @ Yale
In @jcb.org, Kim, Parolek, and Burd @yalecellbiology.bsky.social show that depletion of #cholesterol increases #sphingomyelin synthesis as a result of increased coatomer II–mediated endoplasmic reticulum-to-#Golgi #trafficking of #ceramide, the precursor to sphingomyelin. rupress.org/jcb/article/...
Kim, Parolek, and Burd @yalecellbiology.bsky.social show that depletion of #cholesterol increases #sphingomyelin synthesis as a result of increased coatomer II–mediated endoplasmic reticulum-to-#Golgi #trafficking of #ceramide, the precursor to sphingomyelin. rupress.org/jcb/article/...
Submit your latest research to our upcoming special issue: Cell Biology of the Nucleus. This issue is being coordinated by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social. Deadline: 5 January 2026 journals.biologists.com/jcs/pages/nu...
Congratulations to Amanda Bentley-DeSousa of the Ferguson lab for her paper being selected as one of JCB’s most impactful papers of 2025! @shawnferguson.bsky.social
Journal of Cell Biology@jcb.org · 11mo agoOur annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti... #CellBio2025 @ascbiology.bsky.social
New research led by Devin Clegg that defines how lysosome swelling and lysosome deacidification evoke distinct routes for LRRK2 activation: doi.org/10.1101/2025...
LRRK2 integrates Rab and GABARAP interactions to sense and respond to distinct lysosomal stresses
Increased activity of leucine-rich repeat kinase 2 (LRRK2) is an important risk factor for Parkinson’s disease. LRRK2 localizes to lysosomal membranes, and changes in lysosome physiology are emerging ...
doi.org
We were honored to host Dr. Taekjip Ha as part of our seminar series last week! Postdoctoral fellow Avinash Kumar interviewed Dr. Ha about his research career, mentorship, and more. Read the full article here! medicine.yale.edu/news-article...
Meet Our Speakers: Dr. Taekjip Ha
Professor Taekjip Ha is a world-renowned biophysicist whose pioneering work in single-molecule fluorescence and force spectroscopy has transformed how
medicine.yale.edu
Lipid scramblases and BLTPs are key to regulate cellular lipid dynamics. Justin Korfhage and I described in-vitro methods to study lipid scrambling by protein insertases and ATG2-mediated lipid transfer on artificial lipid droplets. www.sciencedirect.com/science/chap...
Dr. Phyllis Hanson was recently awarded the Sir Bernard Katz Award for excellence in exocytosis and endocytosis research. Congratulations, @pihanson.bsky.social ! medicine.yale.edu/cellbio/news...
Dr. Phyllis Hanson Honored with Katz Award
We are excited to share that Dr. Phyllis Hanson, a former postdoctoral fellow in Yale’s Cell Biology Department, was recently awarded the 2026 Sir Bernard Katz
medicine.yale.edu
Exciting new work from Xiaolei Su’s lab showing how engineering chimeric antigen receptors (CARs) with intrinsically disordered regions (IDRs) increases the efficacy of CAR-T cell cytotoxicity against cancer cells!
Gene Chong@chongg.bsky.social · last yr.The fusion of intrinsically disordered regions to CARs enhances CAR-T signaling by inducing CAR condensation and enhances CAR sensitivity to low-antigen-expressing cancer cells www.nature.com/articles/s41...
We're hiring new faculty! Looking for talented scientists that are interested in pushing the boundaries of Cell Biology. Please spread the word!
Interested in metabolism? So are we! My lab has been exploring the cell biology of energy metabolism in the nervous system, and we are looking for postdocs. Cool sensors and microscopy, great work environment. Please help me spread the word!
We're still accepting submissions for our next special issue: Cell Biology of the Nucleus Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social. Submission deadline: 3 November journals.biologists.com/jcs/pages/nu... #cellbiology #nucleus #notforprofit #freetopublish
Interesting synthetic lethality during mouse development of two bridge-like lipid transfer proteins that are thought to localize in distinct compartments...new work from @pdc-lab.bsky.social in collaboration with @dianekrause.bsky.social: journals.plos.org/plosbiology/...
Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C
VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...
journals.plos.org
CRN Team De Camilli reveals a new molecular mechanism that regulates cystine efflux from lysosomes. This work is relevant to #Parkinsons research, as recent studies show JIP4 is downstream of LRRK2. 🔗 Read their #preprint: bit.ly/4l8zCkf ✏️ @shawnferguson.bsky.social @laylanassar.bsky.social
Join us this Thursday for our mini-symposium with the membrane trafficking webinar series Featuring talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and a keynote lecture from Gillian Griffiths @griffithslab.bsky.social. focalplane.biologists.com/2025/09/16/f...
FocalPlane features... membrane trafficking - FocalPlane
FocalPlane features... membrane trafficking - News
focalplane.biologists.com
Thanks to Min Wu from Yale Cell Bio for a great talk today about information processing at the immune cell surface in the second edition of our new PEB / QBio seminar series. Yale friends, we hope you join us at future talks in this series, happening on Fridays at 11AM!
Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction. www.nature.com/articles/s41...
Nuclear mechanics as a determinant of nuclear pore complex plasticity - Nature Cell Biology
In this Review, Lusk et al. discuss emerging insights into nuclear pore complex variability with regard to composition and dilation state, and propose nuclear mechanics as a key determinant of driving...
nature.com
Happy Post Doc Appreciation Week! We are so grateful to all our post docs for the research expertise, leadership, and mentorship they bring to our department! #NPAW2025 #postdocappreciationweek
Next Thursday Sept 25 (4-6pm CET) we have our first #FocalPlaneFeatures together with our #membranetrafficking community! Thanks to all who submitted such exciting abstracts. The final program is out, featuring a keynote by Gillian Griffiths. Register here: focalplane.biologists.com/2025/09/16/f...
