First 22 hours of zebrafish development. Credit to @zebrafish007.bsky.social at #WeinsteinLab. #ZebrafishZunday 🧪

Inspiring #DesignDay @mcgilluniversity.bsky.social! Proud of Giselle for her capstone presentation on improving islet-on-a-chip platforms to better model development & obtaining a BSc in Bioeng. The fabrication/3D printing wouldn’t be possible w/o collaboration w Juncker lab & @hoeslilab.bsky.social

Great work by @tigerhzjian.bsky.social

Tiger Jian@tigerhzjian.bsky.social · 4mo ago

(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.

Congratulations to all the awardees of IRCM foundation scholarship, including our own Théa Milland & Noah Verreault. I appreciate the donors who made this possible. These awards are competitive & externally reviewed - I highly appreciate the reviewers for their time, effort and support of students!

Junior PI position in cancer research open at the IRCM. Apply below 👇🏽 #PIposition #assistantprofessor #cancer #openposition #ircm

Mathieu Ferron@mathieuferron.bsky.social · 6mo ago

Principal investigator job alert @ircm.bsky.social! We are recruiting a new junior faculty member working in the field of cancer. Apply before February 22nd. Contact me if you have more questions. www.ircm.qc.ca/en/position-...

Today in the 🇨🇦 National Grad course in #Islet Biology and #Diabetes we welcome superstars Cristina Nostro and @yassiag.bsky.social to discuss the latest on using #stemcell derived islet cells as a strategy to treat (cure?) #T1D!

a woman wearing sunglasses and a blue shirt is making a funny face and saying `` no autographs please '' .

ALT: a woman wearing sunglasses and a blue shirt is making a funny face and saying `` no autographs please '' .

media.tenor.com

Wrapping up a great year for the lab. We in 2025 we expanded and reached some important milestones as a growing team. Grateful for the collective effort and momentum. Wishing friends and colleagues a restful holiday season and a happy start to the new year.

Lietzke et al. demonstrate that pluripotent stem cell-derived β cells exhibit reduced oxidative and mitochondrial fatty acid metabolism compared to primary human islets, which is related to limitations in key mitochondrial transcriptional networks. 🧪 #PancSky www.nature.com/articles/s41...

Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells - Nature Communications

Here they show that PPARα-dependent mitochondrial programming promotes the differentiation of pluripotent stem cell-derived β cells. Targeting mitochondria has the potential to improve β cell replacem...

nature.com

(3/3) SCN has supported this work every step of the way. From 2016–2028, SCN has committed over $11.5 million in funding for innovative diabetes research and clinical trials. ✨ Meet the SCN-funded researchers are helping pave the way.

(3/3) Le RCS a soutenu chaque étape de ces travaux, s’engageant à fournir plus de 11,5 M$ de 2016 à 2028 pour des recherches innovantes et des essais cliniques sur le diabète. ✨ Faites connaissance avec les chercheurs soutenus par le RCS qui contribuent à tracer le chemin dans ce domaine.

Proud PI moment at @RéseauThéCell: 🏅 Ying Deng – Best Poster PhD 🏅 Thea Milland – Best Poster MSc 🏅 Giselle de Leon – Best Poster BSc Representing @ircm.bsky.social , Ying and Thea @umontreal.ca , Giselle @mcgill.ca Grateful to organizers Kim Santerre and Dr Corinne Hoesli for this meeting!

It was great honor to attend and present at @navbo.bsky.social Vascular 2025 meeting. Huge thanks to the organizers for putting this tremendous meeting together. And what a special session focusing on vascularization of organoids and disease on a chip models.

📢 McGill University is hiring! The Department of Pharmacology and Therapeutics, with the Meakins-Christie Labs at the RI-MUHC, invites applications for a tenure-track Assistant Professor in Pluripotent Stem Cells in Regenerative Medicine. Learn more and apply. ➡️ stemcellnetwork.ca/wp-content/u...

Interesting and impactful new work by Estall lab: “Here, we identify a novel biological pathway downstream of glucagon that promotes the hepatic lipid accumulation associated with fasting” 👇🏽👇🏽👇🏽 #Glucagon #MASLD #Fasting

Jennifer Estall@dnachicken.bsky.social · 10mo ago

I am happy to share the latest preprint from our lab (@ircm.bsky.social, @umontreal.ca, @mcgill.ca) exploring why and how the liver gets fatty when you are fasting, and how this could impact MASLD. www.biorxiv.org/content/10.1... 🧵1/6

Congratulations to Dr. Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research as well as his commitment to collaboration and innovation in health. 🔗 bit.ly/3HGWhX3

I’m one of the mentors for this year long internship :) Apply if you have interest in writing and Science Communication. There’s opportunity to get some of your pieces in DB @devbiol.bsky.social! Apply today!!

Society for Developmental Biology@socdevbio.bsky.social · 12mo ago

🚨Only 4 days to apply!!!🚨Join the SDB SciComm Internship! Gain hands-on experience writing stories on the latest developmental biology discoveries🔬Connect with top mentors & earn $500 to attend the SDB Annual Meeting 🎉! 👉 www.sdbonline.org/science_comm... #SciComm #DevBio

Very proud to share the first review from the lab with contributions of all lab members. Writing this gave our new lab opportunity to read and discuss many papers and grow as a team. www.frontiersin.org/journals/imm...

Very excited about our project aiming at advancing cell therapies for type 1 diabetes. and very thankful for receiving funding from @stemcellnetwork.ca

Stem Cell Network@stemcellnetwork.ca · last yr.

🚨 BIG NEWS! SCN announces $33M to advance 36 #RegenerativeMedicine research projects and #ClinicalTrials! Learn more. ➡️ stemcellnetwork.ca/research/res...

Preza et al. show that a circadian transcription factor specific to maturing stem cell-derived-β cells, DEC1, regulates insulin responsiveness to glucose. 🧪 #PancSky #StemCells www.biorxiv.org/content/10.1...

DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm

Stem cell-derived islet (SC-islet) organoids offer hope for cell replacement therapy in diabetes, but their immature function remains a challenge. Mature islet function requires the β-cell circadian c...

biorxiv.org

Stem cell-based models of early human development Read this Development at a Glance Article by Lizhong Liu @liliulab.bsky.social and Jun Wu @jun-wu-lab.bsky.social: journals.biologists.com/dev/article/...

Bonifacio and Ziegler summarize current evidence and guidance while emphasizing the need for continued research alongside broader screening application in #type1diabetes. 🧪 #PancSky dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...

Type 1 diabetes risk factors, risk prediction and presymptomatic detection: Evidence and guidance for screening

Type 1 diabetes is recognized as a chronic disease with a presymptomatic phase that does not require insulin therapy and a clinical phase where insulin treatment becomes necessary. The presymptomati...

dom-pubs.onlinelibrary.wiley.com

A protective INS SNP causes accelerated IRE1α-dependent decay of insulin mRNA, alleviates ER stress and reduces beta-cell immunogenicity www.cell.com/cell/fulltex...

Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay

Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...

cell.com

Enterovirus infections may occur throughout the natural history of type 1 #diabetes and may be associated to islet cell HLA-I hyperexpression. @teresarc.bsky.social @sarahibex.bsky.social #T1D #DiabetesResearch link.springer.com/article/10.1... 🔓

Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes - Diabetologia

Aims/hypothesis Earlier studies of pancreases from donors with type 1 diabetes demonstrated enteroviral capsid protein VP1 in beta cells. In the context of a multidisciplinary approach undertaken by t...

link.springer.com

Hao Yin@haoyin.bsky.social · last yr.

Cdc42 coordinates PDGFRb+ Mural Cell migration proliferation morphogenesis (wrapping filopodia) during postanatal retinal #Angiogenesis👁️ PDGFRb+ mural cell Cdc42 KO🐭➡️ ⏫Angiogenic front leakage ⏬Tip cell filopodia Perturbed arterial patterning #VasPharma 2025 www.sciencedirect.com/science/arti...

I've been really hoping someone would do a study like this! www.mcponline.org/article/S153...

Deleterious knock-outs in the HLA class I antigen processing and presentation machinery induce distinct changes in the immunopeptidome

The human leukocyte antigen (HLA) processing and presentation machinery (APPM) is altered in various diseases and in response to drug treatments. Defects in the machinery may change presentation level...

mcponline.org

Nice discussion on the usefulness of genetic and autoantibody screening in children for T1D

Islet Biology Lab - UMH@isletbiologylab.bsky.social · last yr.

Bonifacio et al. estimate that a screening approach that uses repeated islet autoantibody testing results in the greatest sensitivity for identifying youth who are in a presymptomatic stage of #type1diabetes. #PancSky link.springer.com/article/10.1...

Happy Persian new year, Norouz, and the beginning of spring! 🌸🪻☀️

Today, rising stars @drprentice.bsky.social and @yassiag.bsky.social swing through the 🇨🇦 National #Islet and #Diabetes Course to discuss the latest on vascularizing stem cell-derived islet cells, adipose-islet communication, beta cell proliferation, and more @cirtn.bsky.social

a man holding two cell phones with the words kind of a big deal

ALT: a man holding two cell phones with the words kind of a big deal

media.tenor.com

Honored to have recieved this together with Dr Hoesli and @martinsauvageau.bsky.social

Institut de recherches cliniques de Montréal (IRCM)@ircm.bsky.social · last yr.

Au cœur de l’innovation biomédicale au Québec! L’IRCM félicite ses chercheurs Yasaman Aghazadeh et Martin Sauvageau pour un octroi du réseau ThéCell (Réseau de thérapie cellulaire, tissulaire et génique du Québec) pour un projet structurant en ARN thérapeutique. Avec Corinne Hoesli de McGill U.

More cause to celebrate in this anti science climate! Happy international day of women and gender minorities in science 🧬