🧬 Preprint! 🧵 Our goal is to genetically manipulate every embryonic germ layer to enable high throughput in vivo studies. We previously showed mouse ectoderm can be targeted by amniotic injection, enabling cell-specific manipulation, lineage tracing, and knockouts. But how to reach mesoderm?

Issue 17 is now complete! Cover: A female Paryhale stained with phalloidin & DAPI, imaged by Natália Heloísa de Oliveira, Fernanda Salce & @federicasalatiello.bsky.social, at the 2025 @devbioquintay.bsky.social, winning the Node image competition. thenode.biologists.com/winners-from...

Authors!🚨 While you scramble for scarce $ 🤔 “Springer Nature reports revenue growth of 6.2%..and adjusted operating profit growth of 7.7%. They reported even more stunning submission growth of 30% and published article growth of 13%.” Publishing in society journals helps YOU not them👇🏻. Pass it on.

Man Lying on a Pile of Money

ALT: Man Lying on a Pile of Money

static.klipy.com

🚨 New paper out! 🧬IRS2 helps build the placental maternal–fetal interface and supports fetal growth 👶🔬 A fantastic team effort using trophoblast stem cells, organoids, mouse models & more! Congrats to everyone involved! 🎉🥦 www.cell.com/stem-cell-re... #Placenta #stemcells @cbm-csic-uam.bsky.social

Insulin receptor substrate 2 regulates placental syncytiotrophoblast differentiation at the maternal-fetal interface

Grinat et al. identify IRS2 as a central regulator of placental syncytiotrophoblast differentiation. Using mouse genetics, CRISPR-engineered trophoblast stem cells, and human trophoblast stem cells an...

cell.com

Dear reviewers of scientific manuscripts using AI to spit a 5 page long comment focused on tiny details and suggestions to rephrase sentences: I know you used, it is not constructive for me. To editors: please check the reviews are not AI generated before a decision

So how does this work, we ask for a refund? In my mind when you pay to buy something it should work as sold? Biology, a research field where you have to validate yourself everytime what you pay with tax payers money and it is normal.

Reese Richardson@reeserichardson.bsky.social · last mo.

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

i’m never gonna be able to fire a cruise missile yet the question of using my tax dollars for them has never been up for debate

USA TODAY Opinion@usatodayopinion.usatoday.com · 2mo ago

Opinion: Mamdani's idea may sound appealing, but it's NYC taxpayers who will take the hit, subsidizing discounts they may never even use.

The next time a climate change denier comes at you with that excuse:

Please read this if you do one thing today. Makes the blood boil. www.science.org/content/arti...

Exclusive: Death of girl in Chinese gene-editing trial was never made public

Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals

science.org

🚨 Want to start your lab in Marseille on a broad neuronal/brain development theme? There's an exciting tenure track opportunity at @inp-marseille.bsky.social and others Marseille institutes! Check more details here: neuro-marseille.org/en/blog/juni... or contact me if you have any question

🚀Excited to share our latest efforts in bringing highly multiplexed whole-mount imaging to intact multicellular systems! Shield-4i: an integrated platform to study multi-scale information flow in 3D embryos and embryo-like systems. Kudos to @rhornb.bsky.social for this major milestone in the lab!🚀

Excited to share that our work on ‘How the gut gets patterned during regeneration’ is out now cell.com/cell/fulltext/S0092-8674(26)00696-3 Thanks a lot to @priscaliberali.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social and all co-authors! 🧵

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

cell.com

It is out 😍 check it out!! Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning. @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social www.cell.com/cell/fulltex...

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

cell.com

As you might imagine, as someone who studies science and works on metrics, I have some thoughts on qed myself. I fully agree that the messaging can be described as tone-deaf and problematic. I don’t think it had to be. ripplingideas.org/2026/06/26/t...

The 1% club and the rocky road ahead for bioRxiv

The recent launch of qed’s “top 1%” preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. Whil…

ripplingideas.org

Don't use slop. Someone's trying to make money out of you and your colleagues and your friends. Do yourself a favor and read 100% human-crated content in @prelights.bsky.social Upload preprints. Read preprints. Cite preprints. Fuck AI 🧪

Homepage - preLights

Welcome to preLights, the preprint highlights service run by the biological community and supported by The Company of Biologists. Here, a team of scientists regularly review, highlight and comment on ...

prelights.biologists.com

Noticeable underrepresentation of women as corresponding authors in the 1%. Almost as if AI has been trained on years of discriminatory behaviours and is perpetuating that bias.

Please do chat to Dominique and Saanjbati about submitting to Development and our upcoming Special Issue – Plant and Algae Development #DevSIPlantAlgae journals.biologists.com/dev/pages/pl...

Development@dev-journal.bsky.social · 3mo ago

Are you attending ICAR 2026 next week (from 22-26 June) at National University of Singapore? @dev-journal.bsky.social Editor, @stanfordstomata.bsky.social, and Reviews Editor, @saanjbati.bsky.social, will be there. Feel free to chat with them about your next Development paper.

Really enjoyed reading this well grounded piece by @amjeve.uk and @jamesbriscoe.bsky.social on the dreaded metric.It has many good recommendations, the only thing I would add is also the nice pre-print boom and what does this mean for citations of articles. journals.biologists.com/dev/article/...

The elephant in the room: impact factor

Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...

journals.biologists.com

The array of organs in the animal body differ dramatically in their architecture, but cell-cell adhesion mediated by cadherins is a common principle. Our lab usually focuses on epithelia but cadherins are also active in migrating mesenchymal cells like these migrating testis myoblasts 1/n 🧪

New preprint, where we present scFAIR, a consortium of single-cell data resources that has developed a unified metadata schema and common curation framework to improve the FAIRness of scRNA-seq data. www.biorxiv.org/content/10.6...

scFAIR Consortium: a decentralized hub for single-cell RNA-Seq data standardization and unification

The rapid accumulation of single-cell RNA-Seq (scRNA-seq) data across multiple repositories presents major challenges for data accessibility, integration, and reproducibility. While primary…

biorxiv.org

Our new paper on interferon signaling during the response to heart injury is out today. doi.org/10.1242/bio....

Interferon signaling is required for early neutrophil recruitment after zebrafish heart injury

Summary: Interferon-Φ1 signaling is required for early neutrophil recruitment after zebrafish heart injury, revealing a key immune trigger that shapes inflammation and may influence efficient cardiac ...

doi.org

I guess here we are with censorship? Diabetes experts removed from conference

Carl T. Bergstrom@carlbergstrom.com · 4mo ago

"911, what's your emergency?" "Hello, Police? Yeah, our highest award recipient is at our meeting handing out copies of an article that we published. And uh....we....well....shit, nevermind." (gift link)

Call for Papers Submit your latest plant and multicellular algae #DevBio research to our upcoming special issue – Plant and Algae Development #DevSIPlantAlgae Editors: @stanfordstomata.bsky.social & Susana Coelho Deadline: 2 November 2026 journals.biologists.com/dev/pages/pl...

Fixed-dose streptozotocin combined with high-fat diet induces a stable type 2 diabetes-like phenotype in C57BL/6J mice https://www.biorxiv.org/content/10.64898/2026.06.01.728717v1

Scientists have developed a human #CardiacAssembloid model that recreates neural control of #pacemaker activity and atrial conduction. Check out the paper: https://bit.ly/4wOuFEb Tune into the discussion: https://bit.ly/4tWDOI3

Awesome Thermo and great reply from company -.- 400 per tube for these

Reese Richardson@reeserichardson.bsky.social · 4mo ago

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. Paper->> www.nature.com/articles/s41... Next www.biorxiv.org/content/10.6...

New paper from the lab! Spoiler: data driven methods performed better for normalisation than spike in CUT&RUN (again). Congratulations especially to Krutika Ambani for most of the work here now embarking on a PhD.

bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · 4mo ago

Benchmarking normalisation methods for differential binding analysis in CUT&RUN https://www.biorxiv.org/content/10.64898/2026.05.24.727463v1

📣 Preprint alert! We developed a method to analyze concurrent interactions between multiple chromatin regions at single alleles at sub-nucleosome resolution (multi-way Micro-Capture-C, mwMCC) & used this to study structural synergy within super-enhancers. 1/14 www.biorxiv.org/content/10.6...

Only FIVE DAYS LEFT to register for the 2026 Santa Cruz Dev Biol meeting! Great speakers! Tons of talks selected from abstracts! Workshop with Scott Fraser! Workshop with Rashmi Priya! Redwoods trees! 🧬🐸🐟🪰🐭🪱🍃🔥🔬. @devbiol.bsky.social @socdevbio.bsky.social scdb2026.sites.ucsc.edu