Dirk and Kurt are doing great work with their startup Claryx using clinical isolate and environmental genomics/metagenomics for infection control, and it's a delight to be along for the ride and contribute in a small way: www.linkedin.com/posts/kurtha...

New research article Antimicrobial selection and multidrug resistance in four major pathogens in the US Veterans Affairs health-care system: a multicentre, retrospective, cohort study www.thelancet.com/journals/lan... #IDSky #ClinMicro #AMR #OpenAccess #OA

I'm excited to share a preprint that's been years in the making: the idea took shape during the COVID pandemic. Anecdotally, people would sometimes spread COVID at work but not at home, and vice versa. Why? One explanation would be if infectiousness is fleeting...

How bursty infectiousness shapes epidemic dynamics

An epidemic’s expected course is determined by the magnitude and timing of a typical person’s infectiousness — captured, in turn, by the basic reproduction number and the generation-time distribution....

medrxiv.org

Our GoGoVax trial is now published. We found no evidence that 4CMenB prevents gonorrhoea in gay and bisexual men at high risk of infection, providing important evidence to guide gonorrhoea prevention efforts. Thanks to all participants, clinics, & collaborators involved. www.nejm.org/doi/full/10....

Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection | NEJM

No vaccines are currently licensed for the prevention of Neisseria gonorrhoeae infection. Observational studies suggest that the four-component meningococcal serogroup B vaccine (4CMenB) may reduce...

nejm.org

👀👇 New work on sexually transmitting Shigella (press-friendly: bit.ly/4bBarEL) From continued collaboration with @clairejenkins2.bsky.social @ukhsa.bsky.social, @pducambridge.bsky.social co-lead @hsalje.bsky.social, a talented student Julia Marshall www.linkedin.com/in/julia--ma..., and others! 🧫🧬💊

The Lancet Infectious Diseases@thelancetinfdis.bsky.social · 4w ago

New Research The spread of sexually transmissible drug-resistant shigellosis in England: a genomic epidemiology study www.thelancet.com/journals/lan...

Can bacterial genomics bring 70 years of epidemiological surveillance back to life? We're hiring a postdoc (2–3 years) to explore the historical evolution of Salmonella Typhi using a unique genomic dataset. More details: euraxess.ec.europa.eu/jobs/449895

Are you a computational immunologist or bioinformatician interested in impactful vaccine research? We're hiring a postdoc to join @psioxford.bsky.social work in vaccine immunology and evaluation, working on the ChAdOx1 Nipah vaccine. Please get in touch! my.corehr.com/pls/uoxrecru...

New comment Genotype-based antimicrobial resistance tests need a new regulatory framework www.thelancet.com/journals/lan... #IDSky #ClinMicro #AMR #OpenAccess #OA

Calculations on the containment of Bundibugyo ebolavirus with @caseymiddleton.bsky.social: www.medrxiv.org/content/10.6... We estimate: 1. Symptom screening misses 68%–86% of infected travelers. 2. A 7d post-travel quarantine misses 26% of infections. → 18%–23% missed by combined measures. 1/

👉 Only 2 weeks to go for registrations to the famous ICARe course on #antimicrobials and #resistance in #Annecy, France: www.icarecourse.org Great course, great venue, great networking opportunity with @gdwantibiotics.bsky.social and other huge legends in the field

🚨 Disease modelers: Do you use empirical VE estimates interchangeably to inform vaccine effect parameters? Me too, and it’s distorting our predictions. VE estimates often do not align with model parameters. We discuss these pitfalls & solutions in our new preprint: arxiv.org/abs/2605.18571 🧵👇

Incorporating vaccine effects into epidemiological models: common pitfalls and solutions

Incorporating vaccination into mathematical models appears deceptively simple: models integrate vaccine-derived protections, such as reduced susceptibility to infection, using parameters informed by e...

arxiv.org

Thrilled to have my first PhD paper with @mmdesai.bsky.social out! @science.org Link: www.science.org/doi/10.1126/... Thread below: #mevosky #evosky #evobio #popgen #evolsky #ecoevo #molevol

Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load

Understanding the evolutionary mechanisms that maintain sex despite its direct costs is a long-standing challenge. Previous work has shown that sexual recombination can accelerate adaptation, in part ...

science.org

Shreyas Pai@theshreyaspai.bsky.social · last yr.

Why is sex so common if it's so costly? Super excited to share our new preprint “Sex decreases the pleiotropic costs of local adaptation”, where we bring a new angle to this age-old evolutionary question. Co-led by Parris Humphrey, in Michael Desai's lab. Short thread here: (1/n)

Interested in a *staff computational scientist* position? We are looking for an experienced computational biologist (ideally with microbiology experience) to support published packages while also driving new research. Pay range $73k-$111k w excellent benefits. careers.peopleclick.com/careerscp/cl...

Computational Biology Program Scientist

MIT - Computational Biology Program Scientist - Cambridge MA 02139

careers.peopleclick.com

What Eric and Sonia have done for this field is unlike anything I've ever seen in science.

Broad Institute@broadinstitute.org · 4mo ago

A new drug candidate designed to slow the progression of prion disease is entering a phase 1 clinical trial. The trial, led by Eric Minikel, codirector of Broad’s Prion Therapeutic Science program, will evaluate a divalent small interfering RNA (siRNA) drug candidate for safety and tolerability.

Barry Bloom, former dean of @hsph.harvard.edu & a leading immunologist, recently died at the age of 88. Two colleagues, @mlipsitch.bsky.social & @yhgrad.bsky.social, have written a lovely tribute of the man and his work. www.statnews.com/2026/03/30/b...

Remembering public health pioneer Barry Bloom: a scientist, a mentor, a mensch

Marc Lipsitch and Yonatan Grad pay tribute to their former colleague and mentor Barry R. Bloom.

statnews.com

www.statnews.com/2026/03/30/b... @mlipsitch.bsky.social and I shared a few words about a giant of public health and immunology--and a beloved friend and mentor, who bridged basic science and its translation on a global scale.

Remembering public health pioneer Barry Bloom: a scientist, a mentor, a mensch

Marc Lipsitch and Yonatan Grad pay tribute to their former colleague and mentor Barry R. Bloom.

statnews.com

“It was Barry who discovered that lymphocytes-not macrophages, as some hypothesized-that carry immune memory. showed that lymphocytes signal to macrophages through a chemical they termed MIF-which, together w/ interferon, were the 1st cytokines discovered” www.statnews.com/2026/03/30/b...

Remembering public health pioneer Barry Bloom: a scientist, a mentor, a mensch

Marc Lipsitch and Yonatan Grad pay tribute to their former colleague and mentor Barry R. Bloom.

statnews.com

I'm thankful to MBE for publishing this paper. I wan't sure anybody would. The handling editor (I now know was Jeff Townsend) was great, as were the 2 reviewers. It is not an outcome/product/discovery, it is my way of thinking about HGT & pangenomes 1/3 academic.oup.com/mbe/article/...

Genomic perplexity and the evolution of context-dependent function

Abstract. The fundamental principle that selection acts on a gene's function often assumes implicitly that this function is fixed and intrinsic. However, e

academic.oup.com

What happened after the weird Sept 2025 White House press conference on autism? 📉 Tylenol use in the ED dropped >10% among pregnant patients 📈 leucovorin rx jumped 93% among kids 5-17 immediately afterwards new @thelancet.com today with @jeremyfaust.bsky.social www.thelancet.com/journals/lan...

Changes in paracetamol and leucovorin use after a White House briefing

Changes in federal prescribing recommendations follow deliberate and transparent processes involving US Food and Drug Administration (FDA) scientists, which normally include input from stakeholders an...

thelancet.com

You know that annoying NSF form "List every coauthor/co-PI from the last 4y" ? At @cevianlabs.io we built a free tool that drafts the COI form from your PDF CV in minutes. Check it out 👇

Cevian Labs@cevianlabs.io · 5mo ago

Today we’re excited to announce a new product: COI Pond is a tool for faculty and grant staff that converts an academic CV into a draft NSF Collaborators and Other Affiliations (COA) Form. COA forms are tedious work, and COI Pond makes it a snap. Try it for free, here cevianlabs.io/coipond/start/ /1

Dr. Bhattacharya recently came to U. Chicago for an "off the record" event. My strong impression was that he is truly unfamiliar with how most biomedical research works.

Jeremy Berg@jeremymberg.bsky.social · 6mo ago

A second email, this with a more substantial insight about "The Replication Crisis"... 1/5

Something very different and cool for my lab. Sequencing a 4.4mb TB genome using the Artic-style PCR amplicon method with >5128 primers in two reactions 🤯 Enables culture-free WGS for TB! journals.asm.org/doi/10.1128/...

I am seeking a postdoc to join my group at UCLA -- ideally the candidate would have some experience in either population genetics or microbes/microbiome (computational background needed). We have a range of projects and are happy to tailer to your interests. Please dm/email me if interested.

Now published: our work using phylodynamics from surveillance data to quantify and experimentally validate the fitness impact of antibiotic resistance determinants & how this changes with patterns of antibiotic use: www.nature.com/articles/s41...

Quantifying the real-world impact of antibiotic use and genetic determinants of resistance on gonococcal dynamics

Nature Microbiology - Phylodynamic modelling shows how the changing antibiotic landscape and genetic determinants of resistance shape real-world gonococcal dynamics. Experiments validated that...

nature.com

Yonatan Grad@yhgrad.bsky.social · last yr.

New preprint! How much does antibiotic use shape bacterial lineage dynamics, and how does that relate to the fitness costs/benefits of resistance determinants? All sorts of fun findings and a method that we hope will be broadly useful. See @dhelekal.bsky.social's thread and the preprint!

Models can be powerful tools to study associations in data. But do they reliably reveal the truth? 🚨 In our new study, @danlarremore.bsky.social and I show that the model used to estimate VE from test-negative designs (TNDs) may not translate to other correlates of risk. doi.org/10.1093/aje/...

Statistical methods for estimating the protective effects of immune markers using test-negative designs

Abstract. While widely used to study vaccine effectiveness, test-negative designs (TNDs) also provide a platform for identifying and quantifying immunologi

doi.org

6. @yhgrad.bsky.social's group used modeling to ask how best to deploy new antibiotics for #gonorrhea. Their findings suggest that introducing 2 new drugs alongside 1 current therapy is more effective at minimizing resistance than holding new agents in reserve! 🔗: academic.oup.com/cid/article/...

This is a great @cidjournal.bsky.social supplement for all you #gonorrhea, #STI, and #AMR enthusiasts. Or for anyone who’s heard about drug-resistant gonorrhea and wants to learn more. Will link articles in 🧵 below - check it out and share! #openaccess #IDsky #STIsky bsky.app/profile/carb...

CARB-X@carb-x.bsky.social · 7mo ago

📘 New publication supported by CARB-X! A new supplement in Oxford University Press Clinical Infectious Diseases highlights why treatment diversification is essential to address rising drug resistance in N. gonorrhoeae. #IDSky 🧪 🔗 Read here: bit.ly/45KVg90