Proud that our work was published in JACS! 💫🧪🧫 This was a fruitful collaboration with the @dubelab.bsky.social. A true interdisciplinary effort to build multifunctional light controllable molecules for biomedical applications and future drugs. Amazing job by Manuel Valentin and David Féval! 👏

A Multifunctional and Secure Photoresponsive Proteasome Inhibitor to Control Cell Fate

Abstract. Precise external control of biological processes represents a central interest in the life sciences. Specifically designed molecular tools are id

pubs.acs.org

Amazing imaging of the RhoA activity waves during cytokinesis!

Journal of Cell Biology@jcb.org · 2w ago

Michaud, @andrewgoryachev.bsky.social, von Dassow, @xenresearchcenter.bsky.social et al. identify a versatile cortical pattern-forming circuit based on #Rho, F-#actin, Ect2, & RGA-3/4 rupress.org/jcb/article/... 📕 In "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

Great Lab reunion with the @tdvalilab.bsky.social from the LMU Munich! Together we enjoyed the Botanical Garden in Erlangen and visited Emmy Noether's birth place and learned about her hardships in life and academia.

New molecular motor incoming! We proudly present a different type of light-driven motor – it is fast, it moves by a unique mechanism, and it stores a lot of light energy. Check out our newest and supercharged molecular machine at @natchem.nature.com - great collab with Carolin Müller lab!

Nature Chemistry@natchem.nature.com · 2mo ago

A supercharged molecular motor operating by constitutional alteration and proton transfer #chemsky

Great tool for the community!

Gavin Woodruff@weirdworms.bsky.social · 3mo ago

WormTagDB: a systematic survey of endogenously tagged proteins in Caenorhabditis elegans and roadmap toward the tagged proteome academic.oup.com/g3journal/ad...

Congratulations Alina! You did an amazing job! Have a good start at NYU!

TDvaliLab@tdvalilab.bsky.social · 4mo ago

Now it's finally time to congratulate Dr. Alina officially! @Alina, wishing you all the best in your next frontier as a postdoc at NYU. 🎉🥂💫

New Paper Alert! 💥 Check out our next generation multifunctional proteasome inhibitor controlled by light. A versatile and customizable chem-bio tool for steering cell fate. Congratulations to David and Manuel from the @dubelab.bsky.social on this fruitful interdisciplinary collaboration! 🧪 🔬

Künstliche Muskeln mithilfe von winzigen molekularen Maschinen herstellen: Prof. Dr. Henry Dube (FAU) möchte Materialien für völlig neue Anwendungen entwickeln. Diese könnten durch Licht gesteuert werden und programmierbar sein. Das Projekt wird mit mehr als 900.000€ gefördert: go.fau.de/1dife

SAVE THE DATE - our next DGZ International Meeting will take place March 14-17,2027, in Bonn, Germany. Stay tuned!

Thanks to the organizers for this great course! It was a pleasure to contribute and being able to present our research.

EMBL Events@events.embl.org · 4mo ago

Yesterday's #EMBOCelegans practicals had participants mounting worms at different stages for real-time imaging and injection 🔬

Cool! 💥 Confinement induces chiral response of a photoswitch! 🥳 Congrats!

DUBE-Lab@dubelab.bsky.social · 5mo ago

Molecular confinement enables chiroptic enhancement and ECD photoswitching. Our newest work on advanced photonic functions is published in Chem! Huge effort from Fabien and the team – we are so proud of you! authors.elsevier.com/sd/article/S... @cp-chem.bsky.social @fau.de

It’s a big leap forward to describe centriolar satellites in C. elegans! This will open new avenues to study their functions during development. Congratulations @tdvalilab.bsky.social and the students Zakiah Talib and @beriltiryakiler.bsky.social. Happy that the Zanin lab could contribute. 🎉

TDvaliLab@tdvalilab.bsky.social · 5mo ago

#C.elegans is about to join the 'centriolar satellites' club. Check out our new preprint #centriolarsatellites: www.biorxiv.org/content/10.6...

Today, we painted all corridors in our labs as a group effort with LOTS of help from others from the department biology @fau.de Thanks to @biomemphys.bsky.social @zaninlab.bsky.social, the cellbio and department admin for joining. It was a great effort with perfect result 🙏💪🍀

Thrilled to report another milestone: 900 nm photoswitching enables NIR-light detection and reversible invisible writing of high-contrast 2D and 3D displays! Check out our newest molecular photoswitch PBFT (peri-benzo[a]fluoranthenethioindigo) at ChemRxiv - doi.org/10.26434/che...

Alle Studierende und Beschäftigte aus NAT und PHIL sollten morgen zu den Krisenversammlungen gehen und sich für eine bessere Gebäudesituation an der FAU einsetzen!

Congratulations to Tamara and Alina! 🫶🏻🎊🎉🥳 It was a pleasure to contribute to the story. If you want to learn more about how the shape and mechanical properties of centrosomes are regulated during mitosis - a must read.

TDvaliLab@tdvalilab.bsky.social · 9mo ago

Our paper on PCMD-1 and centrosome stability is finally online! Congratulations 🎉🎉🎉 to Alina and the entire team! Very proud and grateful - it was an incredible teamwork @zaninlab.bsky.social! @lifescimunich.bsky.social. If you want to read more check it out on JCB! rupress.org/jcb/article-...

Sophia won the poster prize at the @dgz.bsky.social meeting in Heidelberg. Congratulations! 🎉 🥳 😀 If you want to know more about this work check out our preprint: www.biorxiv.org/content/10.1... Also thanks to the organizers for this great meeting!

Stop by at the two lab posters at the @dgz.bsky.social Meeting in Heidelberg! Esther will present Mikhail’s work on asymmetric furrow ingression and Sophia on a novel signaling pathway that positions the cleavage furrow at the right place.

Don't miss the 'Mitosis and Meiosis' workshop organized by simonereber.bsky.social & Thomas Mayer !

DGZ.bsky.social@dgz.bsky.social · 11mo ago

Looking forward to our next #DGZ Focus Workshop on #Mitosis & #Meiosis on Sept. 30 at noon, organized by simonereber.bsky.social & Thomas Mayer - join us!

Joyful day for the lab! 🎉 🥳💫🍻 Fritzi defended her PhD thesis with outstanding honors. Congratulations on this amazing thesis! Here is a list of some of her projects: onlinelibrary.wiley.com/doi/full/10.... pubs.acs.org/doi/10.1021/... www.cell.com/cell-reports... www.biorxiv.org/content/10.1...

📢 Pre-print alert 📢 We are excited to share the lab's first research article! We used our artificial cortex system to investigate how membrane composition regulates self-organized cortical dyanamics. Check it out here: www.biorxiv.org/content/10.1...

Membrane composition-dependent patterning of Rho and F-actin in an artificial cell cortex

Cortical excitability, a phenomenon in which the cell cortex is dynamically patterned with waves of F-actin assembly, has been described in a variety of animal model systems, including embryos of mamm...

biorxiv.org

Deeply honored that our story was chosen for the cover! 🎉 💫🧬

Journal of Cell Biology@jcb.org · last yr.

Our June issue is here! rupress.org/jcb/issue/22... The cover shows end-on views of the cleavage planes during #cytokinesis in one-cell embryos of the nematode #Celegans. From Lebedev et al. @zaninlab.bsky.social‬: (doi.org/10.1083/jcb....).

The Dube Lab is on Bluesky! Welcome! 🤗

DUBE-Lab@dubelab.bsky.social · last yr.

Dube-Lab is on Bluesky!

Congratulations to the Dammermann lab ! Interesting study!

Journal of Cell Biology@jcb.org · last yr.

Pachinger, Dammermann et al. @maxperutzlabs.bsky.social‬ present a model for centriolar satellites not as transport modules but as sites of translation specifically of centrosomal and ciliary proteins. rupress.org/jcb/article/... #centrosomes #cilia

Want to learn more about our work on Anillin during cytokinesis? Check out the Spotlight from the Hickson Lab!

Journal of Cell Biology@jcb.org · last yr.

Spotlight: Chambaud et al discuss new work from Lebedev et al @zaninlab.bsky.social (doi.org/10.1083/jcb....) that reveals how anillin differentially regulates RhoA at the leading and lagging edges of the contractile ring during unilateral furrow ingression. rupress.org/jcb/article/... #Cytokinesis

A cortical pool of LIN-5 (NuMA) controls cytokinetic furrow formation and #cytokinesis completion. New study from Kuheli Adhikary, Sukriti Kapoor, and Sachin Kotak (Indian Institute of Science Bangalore): rupress.org/jcb/article/... #Development #CellDivision #Celegans

We are excited to share our latest work on the role of anillin during unilateral cytokinesis. Congratulations to Mikhail, the leading author, for his excellent work. Big thanks to the @tdvalilab.bsky.social lab for their tremendous support.

Journal of Cell Biology@jcb.org · last yr.

Lebedev et al. @zaninlab.bsky.social @fau.de show that anillin mediates unilateral #cytokinesis by blocking the effector binding site of active RhoA. rupress.org/jcb/article/... #Development #CellDivision

Happy that we could contribute to the story: From Bones to Bugs: Structure-Based Development of Raloxifene-Derived Pathoblockers That Inhibit Pyocyanin Production in Pseudomonas aeruginosa | Journal of Medicinal Chemistry pubs.acs.org/doi/full/10....

From Bones to Bugs: Structure-Based Development of Raloxifene-Derived Pathoblockers That Inhibit Pyocyanin Production in Pseudomonas aeruginosa

The human pathogen Pseudomonas aeruginosa is particularly notorious for its multiple resistance mechanisms. A new concept for anti-infectives is the “pathoblocker” approach, which targets virulence factors to disarm rather than kill pathogens and thus attenuates the development of resistance. Based on the estrogen receptor modulator raloxifene, which had previously been identified as a potential biosynthesis inhibitor of the virulence factor pyocyanin via in silico screening, analogues have been developed as pathoblockers against P. aeruginosa. These compounds reduce the production of pyocyanin by binding to the phenazine biosynthesis enzyme PhzB. Structure–activity relationships (SAR) were explored using nano differential scanning fluorimetry, isothermal titration calorimetry, and 12 X-ray cocrystal structures. Compared to raloxifene, congener 20c shows a 60-fold lower affinity for the human estrogen receptor with a 15-fold increase in pyocyanin inhibitory activity. The comprehensive structural information gathered in this study paves the way for the development of improved pathoblockers with increased potency and selectivity.

pubs.acs.org

We are excited to announce the details for this year’s #DGZ International Meeting, a very special one as we are celebrating 50 years of DGZ! Join us in October in Heidelberg, where the DGZ was founded in 1975. Check the speakers line-up etc. at the poster. Registration: shorturl.at/EHUzb #DGZ50

#TeamTomo visits the centrosome. I remember the centrosome and PCM being one of Julia's first targets when we were postdocs together at @mpibiochem.bsky.social. It's cool seeing the progress here in worms with Jeff. Beautiful #CryoET across the cell cycle. @centriolelab.bsky.social take a look! 🧪🧶🧬

Fabian Zimmermann@fabianzimmermann.bsky.social · 2y ago

Mahamid and Woodruff labs use cryo-ET to look at mitotic centrosomes: Stunned to see the pericentriolar matrix taking shape, and what seem to be ‚S size’ gamma-tubulin complex oligomers capping the end of 11-pf microtubules. www.cell.com/developmenta...