Amazing to see this online today! A very fun project over the past couple of years (made all the better by a great team of people to work with!)

Yulin Zhang@yulinzhang.bsky.social · 6d ago

Good news! Our paper (with @aabiddanda.github.io @sarahaj34.bsky.social @codushlaine.bsky.social and Priya Moorjani) is now officially online! www.science.org/doi/10.1126/...

Minneapolis is so wonderfully weird. Sometime ago a beloved giant oak tree at someone’s house fell due to a storm and they made an annual festival of sharpening a pencil out of the stump. People finding reasons to be joyful and celebrate #lakeoftheislespencil.

In #GENETICS, @jazlynmooney.bsky.social and the team present a unified theoretical framework for understanding how recombination shapes ancestry patterns after admixture. 🔗 buff.ly/7i4EFAc

Headed to #PEQG26 next week? The Sethuraman Lab will be presenting a buncha recent work! Come find us at both poster sessions, and DM/message me if you'd like to chat about the open postdoc position in my lab.

Our preprint on the genetic regulation of mtDNA gene expression in collaboration with @shwetaramdas.bsky.social and @rajivmccoy.bsky.social .

postdoc alert 🚨! NIH-funded postdoc in my lab to work on Ancestral Recombination Graphs in space. Please spread the word widely in your networks, and please reach out if you're interested! (2-3yr position, start date flexible, pay/benefits good!). details here: careers.umich.edu/job_detail/2...

recruitment

Multiple positions available: ​ Postdoc PhD students

genescape.org

Abstract deadline for Midwest Pop Gen 2026 extended to June 12th! Aug 21-22 at UChicago — free, trainee-oriented meeting with talks, posters + Friday BBQ at Promontory Point. Chicago in August doesn't get better than this... jkreinz.github.io/mwpg2026

Happy to present our perspective on how to think about group-differences in genetic risk. With @nicole-kleman.bsky.social , Meng Lin, and Chris Gignoux.

Tread lightly interpreting group differences in genetic risk

Observed differences in mean phenotypic values across human groups have attracted renewed interest with the rise of large-scale genomic studies and polygenic risk prediction. However, the genetic basi...

arxiv.org

I try not to complain about things but biorxiv refused to preprint our perspective piece and arxiv wants an endorsement from two unicorns who have preprinted there in the last 5 yrs in the same subsection before we can post anything. Preprinting shouldn’t be this hard.

📣 𝐖𝐞’𝐫𝐞 𝐡𝐢𝐫𝐢𝐧𝐠 𝐚 𝐩𝐨𝐬𝐭𝐝𝐨𝐜 𝐢𝐧 𝐩𝐨𝐩𝐮𝐥𝐚𝐭𝐢𝐨𝐧 & 𝐬𝐭𝐚𝐭𝐢𝐬𝐭𝐢𝐜𝐚𝐥 𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬! 🌍📈🧬 If you’re finishing a PhD (or know someone who is) and want to work on complex trait biology + 𝑟𝑒𝑎𝑙-𝑤𝑜𝑟𝑙𝑑 𝑖𝑚𝑝𝑎𝑐𝑡, read on 👇

Please share! The USC Department of Quantitative and Computational Biology is searching for a full-time, teaching-track faculty member for the teaching of QBIO undergraduate statistics and computational biology courses. usccareers.usc.edu/job/los-ange...

Eid Mubarak friends!

Friends and Colleagues! I am SO excited to catch up with you all this week at #AABA2026! Here is a quick 🧵summarizing what our 🧪🧬👩🏽‍💻👨🏿‍🔬👩🏼‍🔬🧑‍💻lab will be presenting at the meetings (1/n) @umncla.bsky.social @umnanth.bsky.social www.nievescolonlab.org

Anthropological Genetics Lab at UMN

Anthropological Genetics Laboratories at the University of Minnesota Twin Cities

nievescolonlab.org

Glad to be part of a community that values the well-being and safety of its neighbors.

We visited Renee Good's memorial. There, we met a group of Somali Minnesotans — who too have been viciously attacked for weeks — warmly hosting everyone. Flowers & stuffed animals galore. Neighbors continually offering sambusas & hand-warmers & water. Grief. And belief. Scenes from Minneapolis:

WATCH: Prem Attends Memorial at Scene of Murder in Minneapolis

See what Prem saw at the memorial for the 37-year-old mother killed by ICE in Minneapolis, plus interview with Omar Fateh and residents.

zeteo.com

I'm just delighted to announce our new preprint on genome-scale perturb-seq in CD4+ T cells. We learned both general lessons about the power of perturb-seq, and specific lessons about T cell biology. Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.

Emma Dann@emmamarydann.bsky.social · 7mo ago

Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025

My second dissertation paper is now out in @natcomms.nature.com! Here we introduce the co-expression-wide association study (COWAS) method for identifying pairs of genes or proteins whose genetically regulated co-expression is associated with complex traits. 🧵⬇️ www.nature.com/articles/s41...

Co-expression-wide association studies link genetically regulated interactions with complex traits - Nature Communications

Proteins can affect traits through their interactions with one another. Here, the authors propose the COWAS method to identify pairs of interacting genes or proteins whose genetically regulated co-exp...

nature.com

Preprint online right before the holidays! Excited to share the first piece of work from the Zhang Lab, led by my absolutely stellar postdoc Michelle Kim! In this work, we ask how admixture, selection and demography shape complex trait genetics and GWAS performance www.biorxiv.org/content/10.6...

Determining the driving factors shaping genetic architecture of complex traits in recently admixed populations

Understanding the genetic architecture of complex traits in admixed populations remains challenging due to heterogeneous genetic backgrounds and demographic histories. Mischaracterizing admixture can ...

biorxiv.org

As promised, a longer thread on what I consider to be some of the most interesting and important contributions of this paper (1/10)

Roshni Patel@roshnipatel.bsky.social · 8mo ago

Here, we show that the genetic relatedness matrix (GRM) can be used to control this type of genetic confounding. (Though our model has not been explicitly described in prior literature, we show that it is the basis for existing methods to control genetic confounding... but more on that later.) (4/6)

Our first labsgiving/Diwali celebration 🪔!

Hey Yaniv Brandvain is not on Bluesky but his most recent biostats ebook is live ybrandvain.github.io/biostats/. His stats resources have been so helpful to me as I develop my own stats course, so check it out. Github repo here: github.com/ybrandvain/b...

reminder that my (wonderful, diverse, interdisciplinary) department at the University of Oregon is seeking applications for an Associate/Full Professor of Data Science -- deadline 10/31 and only cover letter/CV needed to apply academicjobsonline.org/ajo/jobs/30328

I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!

Roshni Patel@roshnipatel.bsky.social · 12mo ago

We'll primarily work at the intersection of statistical and population genetics, and we also have active projects related to the ethical and social implications of human genetics (ELSI). Please get in touch if that's a combination that sounds interesting to you!

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

If you are at #ASHG2025 and would like to chat in person, please reach out! My lab is looking for curious scientists to join us, especially (but not limited to) postdoctoral researchers.

We will be at #ASHG25 this year! Some presentations from our group, please stop by! :

🔔 Excited to share our preprint from the largest ever exome-wide association study for T2D in South Asians. We make important discoveries implicating the genes HNF4A, GP2, RNF19A in the aetiology of diabetes and metabolic traits in south Asians. 👉 Read it here:

medRxivpreprint@medrxivpreprint.bsky.social · 10mo ago

Exome-wide association study in 54,698 south Asians identifies novel type 2 diabetes associations with RNF19A, HNF4A, and dissects role of coding variants in GP2 and CDKAL1 https://www.medrxiv.org/content/10.1101/2025.09.24.25336527v1

Whoops, wrong hashtag. If you are going to #ASHG25, check out the line-up! This is perfect if you are a trainee who needs to network but has no idea how to do it. Instead of trying to corner someone at the posters (which is stressful!), schedule a slot and sit down for 15 minutes to chat!

Gen Wojcik@genandgenes.bsky.social · 10mo ago

Are you going to #ASHG2025 next week in Boston? Interested in getting some mentorship from leading figures in the field (and me)? Check out our speed mentoring event on Thursday! Sign-ups are online so reserve a spot ASAP. site.pheedloop.com/event/ASHG25...

Super excited to see our reference bias work out in Cell! Reviewers gave us some excellent ideas, and Maria added on some new analyses that broke down how SNPs from heterospecific references mapped or did not map in a conspecific reference.

Maria Akopyan, PhD@akopyan.bsky.social · 11mo ago

Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox ref—half mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social www.sciencedirect.com/science/arti...

Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!

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