Abhinav Sur

@abhinavsur.bsky.social

Assistant Professor studying intestinal cell fate and differentiation during zebrafish embryogenesis ~ sc-multiomics, genetics | ex-annelid biologist https://sites.arizona.edu/surgutchatter-lab/

What a ride this has been with @jeffreyafarrell.bsky.social!! THANK YOU JEFF for giving me the best 6 years of my life doing science in your lab. I'm finding it extremely hard to say this goodbye! I will miss everyone in the Farrell Lab and especially YOU! 🥹🥹

Jeff Farrell@jeffreyafarrell.bsky.social · 3mo ago

Hard to say goodbye today to the lab’s first postdoc, but so excited to see what @abhinavsur.bsky.social will do in his new lab at U Arizona. We’re going to miss you deeply over here. Safe travels and knock em dead.

📢 We've just published a chromosome-level nuclear and mitochondrial genome assembly for Capitella teleta (~243.6 Mb). Despite a highly conserved gene family repertoire, both genomes show extensive rearrangements, revealing a decoupling of gene family and chromosomal evolution.

I had a lot of fun working on this collaboration and revisiting the scRNAseq data. Although I work on zebrafish now, I still haven't forgotten my spiralian roots. Thanks @chemamd.bsky.social @baxevanislab.bsky.social and Elaine Seaver for the opportunity.

Allan Carrillo-Baltodano@allancarbal.bsky.social · 5mo ago

New from @chemamd.bsky.social lab @qmulsbbs.bsky.social Collab with Elaine Seaver, @baxevanislab.bsky.social @neva-meyer.bsky.social @abhinavsur.bsky.social New chromosome-level assembly for Capitella teleta 🪱 academic.oup.com/gbe/advance-... #DevBio #WormWednesday @genomebiolevol.bsky.social

Figure showing 3 panels,(A) a picture of annelid Capitella teleta on black background, (B) a cladogram with major biological model organisms showing the phylogenetic position of C. teleta and (C) schematics of the 10 chromosomes of C. teleta

Happy International Day of Women & Girls in Science! Today & everyday I am grateful for the opportunity to work alongside & learn from this talented group of women scientists. Funded by grants from the NIH, this team is working to understand how the gut microbiome affects our digestive health.

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Happy New Year! NEW LAB PREPRINT testing how best4+ intestinal epithelial cells develop! best4+ cells are conserved across vertebrates and altered in IBD & colorectal cancer. But they were first molecularly IDed in 2019. We barely know anything about them yet! What do they do?? HOW DO THEY GET MADE?

Abhinav Sur@abhinavsur.bsky.social · 8mo ago

Closing out 2025 with our new preprint where @jeffreyafarrell.bsky.social and I explore development and function of zebrafish intestinal best4+ cells – molecularly described in 2019, conserved in evolution, absent in 🐭, and altered in inflammatory bowel disease. www.biorxiv.org/content/10.6...

Ok, friends! If you’re a Daniocell user, it’s now available again outside of the NIH. Very sorry for any inconvenience this posed for any of you and thanks for your patience. We’re taking additional steps to hopefully prevent similar outages in the future. Happy surfing 🎣

“These findings support the use of zebrafish as a useful comparative model for studying the meninges, provide a foundational description for future zebrafish meningeal research” New work from @biomarina-vg.bsky.social & Weinstein Lab at NIH 🐟

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · last yr.

Anatomical and Molecular Characterization of the Zebrafish Meninges https://www.biorxiv.org/content/10.1101/2025.04.09.646894v1

Great new work led by @biomarina-vg.bsky.social on zebrafish meninges! Particularly 🤩 is the descriptions of ependymin-expressing meningeal cells (not a fibroblast!) & ablation studies showing their essential role in viability. So much more to learn! Congrats Marina & team on this great work! 🦓🐟🧠

Adult zebrafish possess complex multilayered cephalic meninges. Transmission electron micrograph (TEM) images of transverse sections through the dorsal heads of adult zebrafish, at the level of the optic tecta. A, Pseudocolored overview image of the cephalic meninges, revealing multiple tissue layers between the skull and the brain parenchyma. B, Dorsal surface of a dissected adult zebrafish brain, showing the leptomeninges partially peeling away from the underlying brain parenchyma. C, Higher magnification image of the boxed region in panel B, showing multiple leptomeningeal cell layers separated by membrane bilayers (red arrowheads), delimited ventrally by a well-defined basal lamina (pseudocolored purple). D, Nucleated red blood cell-containing blood vessel embedded within the leptomeninges, with desmosomes and junctions connecting individual endothelial cells (arrows). E, Higher magnification image of the boxed region in panel D, showing a portion of the vessel wall with a characteristic endothelial cell-cell junction (arrow). F, Higher magnification image of collagen fibers in the adult zebrafish leptomeninges. G, Pseudocolored overview image of the cephalic meninges, showing separated heavily pigment dura mater (dural meninges) and leptomeninges. multiple tissue layers (pseudocolored) between the skull and the brain parenchyma. H, Higher magnification image of the boxed region in panel G, showing bilayered dural meninges with periosteal dura adjacent to the skull with an underlying meningeal dural cell layer with numerous large melanophore pigment granules (arrows). Scale bars = 3 µm (A), 4 µm (B,G), 1 µm (C,H), 2 µm (D), 0.3 µm (E), and 0.2 µm (F).M, Dorsal view of an adult casper zebrafish head with the optic tectum and cerebellum clearly visible through the thin, translucent skull. The yellow box shows the approximate region depicted in panels N and O. N,O, Confocal images of the meninges imaged through the intact skull of a living Tg(mrc1a:egfp)y251, Tg(epd:mcherry)y715 double transgenic adult zebrafish, showing (N) mrc1a:egfp-positive FGPs and lymphatics (green) and epd:mcherry-positive LBCs (magenta), or (O) only epd:mcherry-positive LBCs (magenta). P, High-resolution, high magnification confocal Z-stack through the leptomeninges on the surface of a dissected Tg(mrc1a:egfp)y251, Tg(epd:mcherry)y715 double transgenic adult zebrafish brain, showing LBCs (magenta) and FGPs (green). The large center image is a dorsal XY view of the reconstructed image stack, and the images below and to the right show single-plane XZ and YZ views along the planes noted by the dashed lines (xz-1, xz-2, yz).
Zebrafish Rock!@zebrafishrock.bsky.social · last yr.

“These findings support the use of zebrafish as a useful comparative model for studying the meninges, provide a foundational description for future zebrafish meningeal research” New work from @biomarina-vg.bsky.social & Weinstein Lab at NIH 🐟