This one is really important. Great work! Some papers don't go on the reading list, you open them right away. 🤓 I can't help but wonder whether there's another level of regulation via acyl chain identity... the PS threshold should highly depend on saturation degree.
A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER membrane, which converts small lipid changes into a cooperative transcriptional response. www.biorxiv.org/content/10.6...