Discovered in the halls of FMI - I can't quite put into words how delighted this made me...

How do psychedelics reorganize cortical communication at the circuit level? In our new paper with @georgkeller.bsky.social we look into how the psychedelic DOI breaks down cortical modularity, and map the underlying cortico-cortical and thalamo-cortical mechanisms in mice – a thread 1/10

Thank you Georg! Very happy to have worked on this. Here is a short 🧵 on what ECT-triggered CSD looks like, and why we think it is going to help shape the future of ECT research. (1/12)

Georg Keller@georgkeller.bsky.social · 4mo ago

For nearly a century, we believed the therapeutic effect of ECT is the seizure. Our latest research suggests we may have been looking at the wrong event. A thread on why cortical spreading depression (CSD) might be the driver of therapeutic benefit. Work led by @therehugolad.bsky.social

💡What if we could reboot sick cells? IOB scientists @timayupov.bsky.social, @vmorenojuan.bsky.social and collaborators led by Botond Roska have developed #MitoCatch, a system that delivers healthy mitochondria directly to diseased cells. A step toward precision mitochondrial medicine. Pic©IOB 🧵👇

I've been waiting for this particular flavor of naysayer review (it's in Swedish). TL;DR: Brain research has failed to deliver on its big promises in the past; ergo, we must be wary now too. Indeed. I was inspired to write Elusive Cures ... /1 lakartidningen.se/kultur/recen...

Neurovetenskapens ständigt dyra löften

Enligt författaren till »Elusive cure« står vi på tröskeln till en helt ny era i hjärnforskningen.

lakartidningen.se

For nearly a century, we believed the therapeutic effect of ECT is the seizure. Our latest research suggests we may have been looking at the wrong event. A thread on why cortical spreading depression (CSD) might be the driver of therapeutic benefit. Work led by @therehugolad.bsky.social

In this interview, @juliabatki.bsky.social, FMI’s newest group leader, reflects on the early curiosity that drew her to science, why FMI is the right home for her lab, how studying cell clearance could help us understand disease, and her love of improv. www.fmi.ch/news-events/...

Curiosity, cell clearance, and improv: A chat with Julia Batki

In this interview, Julia Batki, FMI’s newest group leader, reflects on the early curiosity that drew her to science, why FMI is the right home for her lab, how studying cell clearance could help us un...

fmi.ch

Very excited to share new work by Leonardo Lupori. In mice, a single dose of the antipsychotic clozapine results in changes to behavior and cortical activity patterns that remain detectable a week later. www.biorxiv.org/content/10.6...

Truly beautiful work. The first good evidence that prediction error driven plasticity actually functions to reduce prediction errors!

Rebecca Jordan@beckyjordan.bsky.social · 5mo ago

First preprint from the lab! Using intracellular recordings & analysis of 2-photon imaging data, we show that spiking & neuromodulatory input during experience drive a reorganization of visuomotor inputs in V1 layer 2/3 neurons, consistent with enhanced visuomotor cancellation - bioRxiv link below.

Join us at TENSS 2026 to open black boxes, explain how things/brains work and debate the impact (or lack or it) of various new technologies on understanding of the brain and on society. tenss.ro Apply by: March 15th!

Deadline March 1. Join the new Dietschy Facility for Tissue Science. www.biozentrum.unibas.ch/open-positio...

We think cortex might function like a JEPA. It looks like prediction errors in layer 2/3 are not computed against input (as is the idea in predictive processing), but against a representation in latent space (i.e. like in a JEPA arxiv.org/abs/2301.08243 or RPL doi.org/10.1101/2025...).

Self-Supervised Learning from Images with a Joint-Embedding Predictive Architecture

This paper demonstrates an approach for learning highly semantic image representations without relying on hand-crafted data-augmentations. We introduce the Image-based Joint-Embedding Predictive Archi...

arxiv.org

Anna Vasilevskaya@loghyr.bsky.social · 6mo ago

Our work with @georgkeller.bsky.social on testing predictive processing (PP) models in cortex is out on biorvix now! www.biorxiv.org/content/10.6... A short thread on our findings and thoughts on where we should move on from PP below.

Join leading scientists for a 3.5-day #LakeConference discussion on: "The Neurobiology of Mental Health" at the level of genes, cell types, organoids, circuits, networks and brain systems. Learn more & apply by January 31: https://lakeconferences.org/conf/1ed63fdb-de0c-4a56-a8b3-1f72f93d30ea

Join us this May to explore the biological mechanisms of mental health challenges and treatment strategies. Apply by January 31: lakeconferences.org

1/6 New preprint 🚀 How does the cortex learn to represent things and how they move without reconstructing sensory stimuli? We developed a circuit-centric recurrent predictive learning (RPL) model based on JEPAs. 🔗 doi.org/10.1101/2025... Led by @atenagm.bsky.social @mshalvagal.bsky.social

One of the most promising approaches to making headway in understanding the cortical algorithm that I have seen in a long time! www.biorxiv.org/content/10.1...

Understanding cortical computation through the lens of joint-embedding predictive architectures

Tracking prey or recognizing a lurking predator is as crucial for survival as anticipating their actions. To guide behavior, the brain must extract information about object identities and their dynami...

biorxiv.org

In this first-person account, FMI’s senior communications manager describes taking part in an early human trial that adapts previous experiments in mice to explore how the human brain responds when visual and auditory information suddenly fall out of sync. www.fmi.ch/news-events/...

Inside the tunnel: Experiencing the brain’s response to sensory mismatches

In this first-person account, FMI’s senior communications manager describes taking part in an early human trial that adapts previous experiments in mice to explore how the human brain responds when vi...

fmi.ch

Applications are open for the #LakeConference on the Neurobiology of Mental Health in Lake Thun, Switzerland. 📆 May 17-21, 2026 🏔️ All career stages welcome ⏳ Apply by January 31, 2026 Learn more and apply: https://t.co/WcuXHdWnFa @lakeconferences.bsky.social

Very much looking forward to this collaboration with @georgkeller.bsky.social at @fmiscience.bsky.social, using a cross-species approach in humans and mice to investigate the effects of antipsychotics on cortical circuit function.

FMI science@fmiscience.bsky.social · 10mo ago

FMI’s Prof. @georgkeller.bsky.social and UPK Basel’s Prof. Philip Sterzer have been awarded a 1.5 M CHF @snf-fns.ch grant to study how brain circuit changes underlie schizophrenia — bridging fundamental neuroscience and clinical research from mice to humans 🧠 www.fmi.ch/news-events/...

Join us for the second Neurobiology of Mental Health conference (May 2026) that will explore the biological mechanisms underlying mental health challenges and their treatment. Information and application on: lakeconferences.org. The deadline for applications is January 31st, 2026.

Please share: Postdoc position available in a new collaborative SNSF project with @georgkeller.bsky.social at @fmiscience.bsky.social using a cross-species approach in humans and mice to investigate the cortical circuit mechanisms underlying schizophrenia. Apply at karriere.upk.ch/Postdoctoral...

Stellenangebot Postdoctoral Researcher (PostDoc m/f) 100% Translational Psychiatry Lab for 2 Years bei Universitäre Psychiatrische Kliniken Basel UPK

Forschung in Klinik für Erwachsene (UPKE)

karriere.upk.ch

I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time! www.biorxiv.org/content/10.1...

This year's Ruth Chiquet Prize goes to @solygamagda.bsky.social, who sent a video message, for her work on how the brain detects sensory mismatches. Read more at: www.fmi.ch/news-events/...

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

I often get asked “do you think visuomotor mismatch responses are a mouse thing?” – it looks like at least humans have them as well. very excited by this!

Magdalena Solyga@solygamagda.bsky.social · 12mo ago

A new preprint from our lab with @zelechowski.bsky.social & @georgkeller.bsky.social ! Using wireless EEG + VR, we recorded visuomotor mismatch responses in freely moving humans. Huge thanks to all participants, Keller Lab members and FMI facilities! Read more: www.biorxiv.org/content/10.1...

Ditching months-long delays for fast, constructive feedback. This interview with @solygamagda.bsky.social dives into the experience of publishing with eLife and what it could mean for a more open and efficient future in science.

Publishing with eLife: “the future of science lies in greater transparency”

Neuroscientist Magdalena Solyga shares her latest study and her experience publishing with eLife.

buff.ly

Defending science in public we often talk about 'peer reviewed science'. But could this framing contribute to undermining trust in science and holding us back from improving the scientific process? Instead, let's talk about the work that has received the most thorough and transparent scrutiny? 🧪

We’re pushing for a system that’s fairer for researchers, helping them get recognition for what, not where they publish. Learn about our model that eliminates accept/reject decisions. buff.ly/SCqcG4x

In his new book, published today, Nachum Ulanovsky calls on the field to embrace naturalistic conditions and move away from overcontrolled experiments. #neuroskyence www.thetransmitter.org/systems-neur...

‘Natural Neuroscience,’ an excerpt

In his new book, Nachum Ulanovsky calls on the field to embrace naturalistic conditions and move away from overcontrolled experiments.

thetransmitter.org

How does our brain predict the future? Our review of predictive processing + research program is now on arXiv arxiv.org/abs/2504.09614 50+ neuroscientists distributed across the world worked together to create this unique community project.