With CONSULT now ending, we are delighted to share two reports that summarise our findings 1/n CONSULT aimed to support ethical inclusion in research of adults with impaired capacity to consent through series of studies & methodological interventions: 📆5 yrs 📝9 papers (+ 1 in review) 🗝️8 key findings

No.3 #BJGPTop10 Irritable bowel syndrome: Trying low-dose amitriptyline for IBS outweighed patients' concerns doi.org/10.3399/BJGP... @uos-primarycare.bsky.social @hazeleveritt.bsky.social @riddmj.bsky.social @amandafarrin.bsky.social #ATLANTISTrial #IBS #DigestiveHealth #PrimaryCare #BJGP #research

I'm doing a webinar in two weeks (15 Oct 1-2pm BST), part of NIHR Research Support Service's Methods Academy series, on the age-old question: should I do a stepped wedge trial? Free registration, details here: tinyurl.com/z6cjvce3 @nihr-rss.bsky.social @wiphcem.bsky.social @qmul-wiph.bsky.social

Great to have so many engaged people in the room! More workshops are planned for 2026. Follow us here and on LinkedIn find out about future training opportunities. www.linkedin.com/company/ukcrc-registered-ctu-network/ #UKCTUNetwork #HTBAGCI #ClinicalTrials

Glasgow CTU@glasgowctu.bsky.social · 10mo ago

Yesterday GCTU hosted the UKCRC "How to be a great CI" workshop and it was a fantastic day. The day offered wonderful insights from speakers and a great opportunity to network and create relationships to support future clinical research #ClinicalTrials @uofgmvls.bsky.social @uofgshw.bsky.social

Fern Harvey’s fab poster presentation of her systematic review on process evaluations for complex intervention trials. Better reporting of context, mechanisms of action and fidelity would enable greater learning about successful interventions #ImpSci #EIE2025 @au-primarycareuol.bsky.social

A cluster randomised crossover design incorporates the principles of both cluster trials (where groups of individuals eg wards, schools etc are randomly assigned) and crossover trials where, in this case, the clusters cross over to different treatment/s for set time periods 2/7

At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9 #MethodologyMonday #120

🚀 Exciting News! 🚀 Interested in or leading a clinical trial? Want to be the best Chief Investigator you can be? This updated course is for you! tinyurl.com/HTBAGCI #ClinicalTrials #CITraining @leedsctru.bsky.social @amandafarrin.bsky.social

Phew: ResearchFish submitted again for another year ✅️

A common issue in trials is how to accommodate multiple important outcomes. Approaches include composite outcomes or using the win ratio method (I have posted on these before). A newer method is the #DOOR (Desirability of Outcome Ranking) approach 1/7  #MethodologyMonday #113

📢 Delighted our CHART trial is now OPEN to recruitment Massive effort from our @complexleedsctru.bsky.social trial team, @drandyclegg.bsky.social @vickigphysio.bsky.social & many others to get this complex study ready to go 🎉 🙏 @nihr.bsky.social for funding

ARC South West@arcsouthwest.bsky.social · last yr.

PenARC & @arc-yharc.bsky.social researchers are working in partnership with older people with #heartfailure and #frailty to increase their independence. > Learn more: tinyurl.com/4xt8f7en @nihrarcs.bsky.social @exeter.ac.uk @universityofleeds.bsky.social @livunipress.bsky.social @nihr.bsky.social

Currently low response rates from CTU Directors (n=5), Programmers/Data Managers (n=0), & QA Managers (n=3) working in clinical trials. We need to know what these groups think the challenges are for greener trials. forms.office.com/e/fkeLD8HbMA Please complete &RT @ukctunetwork.bsky.social

Katie Gillies@katiegillies.bsky.social · 2y ago

Do you work on clinical trials? We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials Please share across your networks

Consider what to report about your rehabilitation intervention? Here's a newly published TIDieR Rehab checklist bmjopen.bmj.com/content/14/1...

Follow @freshstart-uk.bsky.social for all updates from our @leedsctru.bsky.social @nihr.bsky.social programme grant. We've just moved over to this platform 🙂

FReSH START@freshstart-uk.bsky.social · 2y ago

FReSH START is a research project aiming to develop a therapy intervention for adults who self-harm. We are now running a clinical trial to see if the therapy we developed is effective and if it improves people's quality of life. #introduction #mentalhealthresearch #selfharm #NIHR

Another link to survey as initial link problematic for some - forms.office.com/e/fkeLD8HbMA

Do you work on clinical trials? We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials Please share across your networks

Interesting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!

American Statistical Association History of Statistics @hos-asa.bsky.social · 2y ago

#OTD 28 Jan 1809 Louis-Dominique-Jules Gavarret b (d 30 Aug 1890) An early proponent of the 'statistical method' in medicine, his 1840 book 'Principes de Statistique Médicale' was among the first to describe statistical principles for rigorous clinical trial conduct. /10 🧵

An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8 #MethodologyMonday #109

Welcome to bluesky @complexleedsctru.bsky.social 🎉 Please do follow our Complex Interventions Division account for our news of our training opportunities, trial progress and results, as well as signposting to relevant resources for Complex Intervention trialists 👇

CTRU Complex Interventions @complexleedsctru.bsky.social · 2y ago

There's only 2 days left to sign up for our Masterclass in the Design and Conduct of Complex Intervention Evaluations! Limited spaces are left! Register here - t.co/V6Q7p51feu

We've frustratingly allowed "real world" to become a deceptive synonym for "observations we happened haphazardly to make". I'd say half the studies that come to me now, the majority of which are useful but modest clinical audits, will have "real world" in the proposal title. It's magic!

I am not that surprised that more women quit academic publishing than men- this chimes with data showing fewer women get their papers published, grants funded if they lead them and that more women get pushed into support roles. We do need to do more to support and mentor female staff. 🧪

Who’s quitting academia? Data reveal gender gaps in surprising fields

Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.

nature.com

Snow day #Yorkshire #Langsett

Want to know how to report a cluster-crossover trial … the CONSORT extension reporting guidance is out 😊 www.bmj.com/content/388/...

Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration

This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups ...

bmj.com

We're running our annual online Masterclass in Complex Interventions Evaluations over 3 days in January and February. Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social Register now to reserve your place. Deadline 24 Jan. Link below 👇

Just a wee bit of snow in Yorkshire 🥶❄️

🤢 horrifying piece of work, which we’ll see idiots quoting. For goodness sake @jclinepi.bsky.social

Journal of Clinical Epidemiology@jclinepi.bsky.social · 2y ago

Treatment Effects in Pharmacological Clinical Randomized Controlled Trials are Mainly Due to Placebo - @jclinepi.bsky.social www.jclinepi.com/article/S089...

Happy New Year! May your 2025 be healthy, prosperous, and full of interesting research questions to explore!

Beautiful light from the late December sun in one of my favourite places today #PeakDistrict #LadyBower to #LostLad and back

Happy Boxing Day from a very sunny Yorkshire 😎🎄 Perfect temperature inversion around #EmleyMoorMast

With the approaching the start of the holidays please remember that HOW to ‘switch off’ is your thing. There’s no manual. Whatever suits you. Checking emails is not a crime during this time but it’s good practice -if you email back- to schedule sending for when the holiday is over.