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Andrew Gulick

@amgulick-lab.bsky.social

Structural Biology Lab – focused on remarkable enzymes of natural product biosynthesis

130 Posts158 Follower128 Folgt
Barrie Wilkinson@barriewilks.bsky.social · 13h ago

Fully funded PhD in collaboration with @matthutchings.bsky.social starting in October 2027. Help us translate recent findings on the global and pathway specific regulation of their biosynthesis into the discovery of new antibiotics. biodtp.norwichresearchpark.ac.uk/projects/dis...

Discovering the next generation of antibiotics (WILKINSON_J27DTP) | Doctoral Training Partnership

The continued evolution of antibiotic-resistant bacteria presents a significant threat to global health and new compounds with novel mechanisms of action are urgently needed.

biodtp.norwichresearchpark.ac.uk

c0nc0rdance@c0nc0rdance.bsky.social · 2w ago

I'll save you the click-through: A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet. It's plausible that Claude found the same signatures independently...

Carl Zimmer@carlzimmer.com · 2w ago

Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc

Andrew Gulick@amgulick-lab.bsky.social · 3w ago

A postdoctoral research position is available in my lab. An official posting will be listed on UBJobs but in the interim feel free to reach out via email with any questions or to submit a preliminary application. (No need to arrange for letters of support yet).

Ad for postdoctoral research position in my lab to study structural enzymology of natural product biosynthesis.
Science X / Phys.org@sciencex.bsky.social · 4w ago

A p38 delta inhibitor achieved 12,000-fold greater selectivity by causing a flexible protein loop to kink and wrap around it. A distant amino acid helps stabilize this unusual fit. doi.org/hcjqf7

Thinking outside the binding site: Drug molecule makes a square peg fit a round hole

A square peg doesn't fit a round hole. But what if the peg could change the shape of the hole? A newly developed drug molecule can do something surprisingly similar when binding to its target protein, according to a University at Buffalo-led study published Tuesday (Sept.

phys.org

Harmit Singh Malik@harmitmalik.bsky.social · last mo.

So (if I understand this correctly), the way AI (companies) will "solve" all the major problems in maths, biology, and medicine in the next 5 years will be by stealing and building on the ideas of researchers naive enough to think their chats with AI companies would be private.

Stephan Hacker@stephanhacker2.bsky.social · 2mo ago

What are the hot topics in Chemical Biology? If you want to learn about the exciting perspective of students of Johannes Morstein's (@morstein.bsky.social) Ch/Bi145 course at @caltech.edu, you can now do so in their ChemBioChem review. doi.org/10.1002/cbic... (1/13) @chemistryeurope.bsky.social

Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech

This student-authored review highlights notable advances in synthetically enabled chemical biology from 2025, spanning bioconjugation and bioorthogonal chemistry, visualization and sensing, precision...

doi.org

Marnix Medema@marnixmedema.bsky.social · 2mo ago

New postdoc opportunity in our team! Topic is computational analysis of (meta)genomic data to study evolution of plant-microbiome interactions. Part of the AEGIS consortium (aegisearth.bio/en). Apply here: www.wur.nl/en/vacancy/p... Please RT!

Postdoc on computational (meta)genomic analysis

Climate change is one of the greatest challenges for global food security, requiring new approaches to understand and harness the natural diversity that enables plants and their associated microbiomes...

wur.nl

Dave Palmer@davepalmerusask.bsky.social · 4mo ago

Our manuscript describing a new 2nd-year laboratory experiment using #biocatalysis in organic chemistry is now available on ChemRxiv! Here's a little thread about the experiment, and how we developed it from work in my research lab. #ChemSky 🧵 /1

Introducing Biocatalysis into the Second-Year Organic Laboratory: Using an Aldolase in the Synthesis of a Sunscreen Ingredient | ChemRxiv

Biocatalysis has become an important part of synthetic chemistry, particularly in the pharmaceutical industry. It is therefore important for chemistry students to learn about biocatalysis in their pro...

chemrxiv.org