I don't know, man, I think if Joe Biden had kept confusing Zelenskyy with Putin and Iran with Japan, the media might have made a pretty big deal about it?
Barrie Wilkinson
@barriewilks.bsky.social
Natural products/specialised metabolism @JohnInnesCentre.bsky.social https://www.jic.ac.uk/people/barrie-wilkinson/ https://www.cmi-norwich.ac.uk/people/prof-barrie-wilkinson/
Another paper out in the @microbiologysociety.org special issue on Advances in the biology of Actinomycetes! Congratulations to everyone involved @matthutchings.bsky.social @barriewilks.bsky.social @johninnescentre.bsky.social www.microbiologyresearch.org/content/jour...
Defining the OrrA regulon and its role in development and antibiotic production in Streptomyces venezuelae NRRL B-65442
Streptomyces bacteria have complex life cycles involving hyphal growth, sporulation and the production of diverse specialised metabolites, including antibiotics. In this study, we investigated the rol...
microbiologyresearch.org
Our study into the incredible genome of Embleya australiensis has been published in Microbial Genomics. We've shown that Embleya carry gigantic secondary chromosomes around 4 - 6 Mb in size! Enjoy reading and don't hesitate to reach out! www.microbiologyresearch.org/content/jour... 🧪💻🦠 1/4
Dear PhD students and postdocs — we want to hear about your science firsthand at our annual Early Career Microbiologists Mini-Symposium @johninnescentre.bsky.social (UK) this September. For more information and to apply: www.jic.ac.uk/event/early-...
Early Career Microbiologists Mini-Symposium 2026 | John Innes Centre
The Department of Molecular Microbiology is organising a one and a half day Early- Career Microbiologists Mini-Symposium. The symposium will be held from Tuesday 22nd – Wednesday 23rd September 2026.
jic.ac.uk
The Microbe Zoo will be going to the Royal Society summer science exhibition 2026!!! Fantastic achievement by @sawtrust.bsky.social and @norwichmicro.bsky.social royalsociety.org/science-even...
If anyone is interested in working on these bacteria @johninnescentre.bsky.social has protocols, strains, plasmids and a genome database available here: streptomyces.org.uk
Streptomyces.org.uk
streptomyces.org.uk
Matt Hutchings@matthutchings.bsky.social · 6mo agoResearch into filamentous actinomycetes, the antibiotic producers, is in steep decline. Loads of natural products chemistry research worldwide but not much aimed at understanding their biology and ecology. The latter is key to unlocking their specialised metabolism link.springer.com/article/10.1...
Research into filamentous actinomycetes, the antibiotic producers, is in steep decline. Loads of natural products chemistry research worldwide but not much aimed at understanding their biology and ecology. The latter is key to unlocking their specialised metabolism link.springer.com/article/10.1...
Revitalizing actinobacteria research: an urgent response to the antimicrobial resistance crisis - Natural Products and Bioprospecting
Abstract The crisis of antimicrobial resistance (AMR) is escalating while the antibiotic pipeline remains stagnant. Our bibliometric analysis of eight decades of literature reveals a critical imbalanc...
link.springer.com
Good to see this out - new CRISPRi work from the @ryanfseipke.bsky.social lab/ #microsky #streptomyces A platform for CRISPRi-seq in Streptomyces albidoflavus journals.asm.org/doi/pdf/10.1...
journals.asm.org
Delighted to see the main work from my PhD finally published in @mbio.bsky.social! It all started with the observation that deleting the cutRS two-component system in S. venezuelae caused this amazing explorer phenotype in the presence of glucose. But what was going on?! (1/n)
Very happy to see this remarkable work published. Led by @tommclean.bsky.social and @ainsley-beaton.bsky.social. We show how Streptomyces bacteria sense & respond to misfolded secreted proteins. A great collaboration with @barriewilks.bsky.social #microsky 1/2 journals.asm.org/doi/epub/10....
The conserved two-component systems CutRS and CssRS control the protein secretion stress response in Streptomyces
journals.asm.org
📄 Delighted to share that the preprint of my main PhD work is out now! 👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏 🧵 below! www.biorxiv.org/content/10.6...
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems
Low-copy-number plasmids often rely on dedicated maintenance mechanisms, such as partitioning systems, to ensure stable inheritance across generations. These partition systems actively segregate siste...
biorxiv.org
If successful, the ViTaL-D Study would be a step towards using biofortified tomatoes to overcome a growing global problem of vitamin D deficiency 🌎 This step forward is of particular interest to people who follow a plant-based diet because vegan sources of vitamin D are nearly non-existent 🌿
Need a winter warmer? Groundbreaking gene-edited tomato soup trial with higher levels of 'Sunshine' vitamin recruiting now - Quadram Institute
Human trial of gene edited food, to understand whether biofortifying tomatoes in this way leads to higher levels of vitamin D in the blood
buff.ly
We are hiring‼️ Two cool projects in my group for a PhD student in plant immunity and for a Postdoc in plant microbiota research 🌿🧫🚀🚀
We have a PhD opportunity available in our group @johninnescentre.bsky.social through the NRP Doctoral Training Partnership. Help us uncover the Hidden Diversity of Bacterial NLRs. Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Beyond Immunity: Uncovering the Hidden Diversity of Bacterial NLRs (SCHLIMPERT_J26DTP) | Doctoral Training Partnership
Join us in exploring the hidden functions of ancient immune proteins in bacteria. Bacteria, like plants and animals, have evolved sophisticated systems to detect and respond to threats.
biodtp.norwichresearchpark.ac.uk
Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!!
John Innes Centre@johninnescentre.bsky.social · 10mo agoShortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026. Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years. Find out more: www.jic.ac.uk/training-car...
Start independent research at the JIC with us 👇. Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes. Please do get in touch by email if you'd like to know more 👍
John Innes Centre@johninnescentre.bsky.social · 10mo agoVACANCY - Independent research fellowships leading to tenured positions We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships. APPLICATION DEADLINE: 10 November 2025 Click here to apply: jic.link/Fellows
There is still some time left to apply for these two Group Leader positions in Plant Biology and Microbe-Plant Interactions. Spread the word, apply & become our colleague @johninnescentre.bsky.social
John Innes Centre@johninnescentre.bsky.social · last yr.We’re pleased to announce two new vacancies for senior roles at our institute: Group Leader in Discovery Plant Sciences: www.jic.ac.uk/vacancies/gr... 🗓️ Closes 25 August Independent Fellowship in Plant-Associated Microbial Interactions: www.jic.ac.uk/vacancies/in... 🗓️ Closes 5 September
Interested in host-associated microbiomes? Attending @eseb2025.bsky.social? Then come check out Symposium S07 on Monday August 18th and hear all about how microbiomes contribute to adaptation. Gut microbiomes, climate change, thermal physiology, behaviour, invasion biology, blood-feeding, and more!
VACANCY - We’re recruiting for a visionary group leader to lead fundamental research on Discovery Plant Science as part of our vibrant research community Successful candidate will be offered a six-year tenure-track position with the opportunity to apply for tenure: www.jic.ac.uk/vacancies/gr...
Ever wondered why some antibiotics are made by Streptomyces on agar plates but not in liquid cultures? Read this work on redox control of antibiotic biosynthesis. Led by katienoble241.bsky.social and Rebecca Devine, and in collaboration with @barriewilks.bsky.social journals.asm.org/doi/10.1128/...
journals.asm.org
Exciting times to be at @johninnescentre.bsky.social ! www.jic.ac.uk/press-releas...
Major funding boost to bring world leading researchers to the John Innes Centre | John Innes Centre
The John Innes Centre has been awarded an equal share of the new £54 million Global Talent Fund, to attract and support leading researchers and their teams to relocate to the UK. The new Global Talent...
jic.ac.uk
We’re pleased to announce two new vacancies for senior roles at our institute: Group Leader in Discovery Plant Sciences: www.jic.ac.uk/vacancies/gr... 🗓️ Closes 25 August Independent Fellowship in Plant-Associated Microbial Interactions: www.jic.ac.uk/vacancies/in... 🗓️ Closes 5 September
Congrats, great to see this out in full!
Sam Mugford@samtmugford.bsky.social · last yr.Aphid Saliva fans, happy news, this amazing story is now out in Science Advances www.science.org/doi/10.1126/... congrats @qunliu07.bsky.social @saskiahogenhout.bsky.social et al @johninnescentre.bsky.social 24h after a triumphant presentation at #ismpmi2025
Delighted to be speaking on "A platform for lantibiotic diversification" at SynBioAustralasia 2025 this November in Wellington. If you’re working at the intersection of biology and engineering — don’t miss it. 🔗 synbioaustralasia.org/upcoming-conference #SBA2025 #SyntheticBiology #SynBioCommunity
SBA 2025 conference
SBA 2025 conference Synthetic Biology Australasia New Zealand synbio conference
synbioaustralasia.org
Super happy to see our work on lydiamycin biosynthesis, structure and function published in @pnas.org 😀 www.pnas.org/doi/10.1073/... The work is described in the thread below, where we use BGC info to guide the discovery of multiple key features of this antibiotic. @johninnescentre.bsky.social
Identification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target | PNAS
The natural products actinonin and matlystatin feature an N-hydroxy-2-pentyl-succinamyl (HPS) chemophore that facilitates metal chelation and confe...
pnas.org
Andy Truman@andytruman4.bsky.social · 2y agoNew pre-print from the group 🥳 We use targeted genome mining to show that the plant pathogen Rhodococcus fascians makes the antibiotic lydiamycin. The BGC information then informed the discovery of multiple key features relating to the molecule 1/4 #biosynthesis www.biorxiv.org/cgi/content/...
EVENT - Early Career Microbiologists Mini-Symposium Join our Department of Molecular #Microbiology Early Career Microbiologists Mini-Symposium. Application deadline: 9 June 2025. Event: 15 - 16 September 2025. The John Innes Centre, NR4 7UH Find out more and apply: www.jic.ac.uk/event/early-...
Early Career Microbiologists Mini-Symposium 2025 | John Innes Centre
The Department of Molecular Microbiology is organising a one and a half day Early Career Microbiologists Mini-Symposium. The symposium will be held from Monday 15 – Tuesday 16 September 2025.
jic.ac.uk
Happy International Day of Immunology! 🧬🔬💉 “Measles: A Dangerous Illness” — a letter by Roald Dahl 'It is not yet generally accepted that measles can be a dangerous illness. Believe me, it is.'
“Measles: A Dangerous Illness” — a letter by Roald Dahl — Superbugs - The microbial world in, on and around us
Originally published in a pamphlet for the Sandwell Health Authority in the West Midlands in 1986
superbugs.online