Amjad Khalaf 🇵🇸

@amjadkhalaf.bsky.social

PhD student with Mara Lawniczak and Mark Blaxter | Tree of Life | Wellcome Sanger Institute | University of Cambridge | Palestinian & Italian

New preprint! We unexpectedly discovered that some Caenorhabditis species delete parts of their somatic genome early in development, which fragments their chromosomes and eliminates key germline genes. Multiple lines of evidence suggest this bizarre process was present in the ancestors of C. elegans

Figure with three panels. Left: phylogenetic tree of Caenorhabditis species, highlighting those with programmed DNA elimination. Middle: plot showing chromosomal locations of eliminated DNA. Right: Images showing DNA fragments being eliminated during early development.
bioRxivpreprint@biorxivpreprint.bsky.social · 10mo ago

Programmed DNA elimination was present in the last common ancestor of Caenorhabditis nematodes https://www.biorxiv.org/content/10.1101/2025.10.23.681605v1

it's really an honour to be interviewed by the wonderful @carmcdhume.bsky.social -- a huge thank you! ❤️🫂

Carmen Denman Hume@carmcdhume.bsky.social · last yr.

Meet @amjadkhalaf.bsky.social. Amjad is a great science communicator. I've listened to him present his research. I've interviewed him twice. I've read his papers. Head to the blog, so you too can get swept up by his enthusiasm and #microsporidian studies ⤵️ sangerinstitute.blog/2025/07/29/s...

New preprint! We generate 40 new high-quality microsporidian genomes from infected arthropod hosts that were sequenced to create reference genomes by the Darwin Tree of Life project. 8 of our genomes are chromosome-level, and we’re able to generate Hi-C data for 7! 🧬 www.biorxiv.org/content/10.1...

Forty New Genomes Shed Light on Sexual Reproduction and the Origin of Tetraploidy in Microsporidia

Microsporidia are single-celled, obligately intracellular parasites with growing public health, agricultural, and economic importance. Despite this, Microsporidia remain relatively enigmatic, with man...

biorxiv.org