🧵 New publication from the PGC Anxiety Working Group. Our GWAS meta-analysis of anxiety disorders is now published in @natgenet.nature.com! 🔗: doi.org/10.1038/s415...

The PGC Suicide Working Group will provide a symposium at #WCPG2025 🇲🇽 covering our latest multi-ancestry GWAS and CNV meta-analyses, sex-specific meta-analyses, and GxEHR analyses. 🥳 @lcstoshio.bsky.social @andreyshabalin.bsky.social @sarahcolbert.bsky.social @caina89.bsky.social

We recently launched The Upright to address the critical gaps in access, effectiveness, and cultural relevance surrounding mental health, suicide prevention, and the lived experience of communities. Learn more about The Upright and join us for The Summit: www.addevent.com/event/MR2473...

Fantastic to see Maria Koromina's great work out in @natneuro.nature.com! 1. A deep look at potential "causal" genetic signals in bipolar disorder 2. A systematic exploration of the analytical choices involved in fine-mapping meta-analysis 1/4 www.nature.com/articles/s41...

Fine-mapping genomic loci refines bipolar disorder risk genes - Nature Neuroscience

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide fu...

nature.com

Latin America has experienced an increase in suicide rate, contrasting with a global decline. We review possible reasons for this here: www.sciencedirect.com/science/arti... Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.

We're excited to introduce Tractor-Mix, our new method for GWAS in admixed cohorts with relatedness, led by the fantastic @doubletaotan.bsky.social! Read the full preprint here: www.medrxiv.org/content/10.1... Thanks to all our amazing collaborators who helped make this work possible!

The OpenMx Team is pleased to announce the release of OpenMx version 2.22!: openmx.ssri.psu.edu/node/4942 The big news in this release relates to GREML (Genomic-relatedness-matrix REstricted Maximum-Likelihood): 2 bug-fixes, a patched memory leak, and 2 new features! 1/n

Postdoc opportunity! At National Genomics Infrastructure in Uppsala we're looking for a postdoc in genomics R&D. Cutting-edge methods dev in an excellent, international environment at the junction between academia and infrastructure. Deadline May 23! www.uu.se/en/about-uu/...

Postdoctoral Researcher, NGI Uppsala, SNP&SEQ Technology Platform - Uppsala University

Postdoctoral Researcher, NGI Uppsala, SNP&SEQ Technology Platform, Department of Medical Sciences, Uppsala University

uu.se

PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

Asked GPT to (impossibly) "write a Bluesky post 100% guaranteed to go viral" Its suggestion: "just saw a guy confidently order a "croissantini" at the coffee shop and the barista nodded like that was a normal word. i live in a simulation." Then I said "Make it more viral" and things got weird... 🧵

New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology. www.biorxiv.org/content/10.1...

Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits

Spatially resolved transcriptomics is transforming our understanding of cellular and molecular diversity of tissues. Here, to identify tissue structures that are enriched for putatively causal disease...

biorxiv.org

@sarahcolbert.bsky.social ‘s #SRS25 presentation: Genome-Wide Association Studies of Suicidal Thoughts and Behaviors in the Psychiatric Genomics Consortium So incredible!

Massive multi-ancestry GWAS resource for 1,167 clinical traits & diseases in 6 global biobanks (n=1,789,365) 👉29,139 locus-trait pairs 👉2,624 non-overlapping loci across the genome 👉associated with 6 traits each (median) 👉colocalization across traits for 72% of loci [1/3]

Please consider helping @kathleenwreardon.bsky.social with this project—and sharing it widely—to improve how we approach teaching HiTOP for a variety of groups and end users csufull.qualtrics.com/jfe/form/SV_...

@kathleenwreardon.bsky.social · last yr.

Take this brief survey on how mental health stakeholders (students, researchers, clinicians) learn about HiTOP (@hitop-system.bsky.social) - also including common challenges & misconceptions. csufull.qualtrics.com/jfe/form/SV_... Please share to help improve HiTOP education! 💡

Excited to be in Salt Lake City for our 2-week NIH training course in Advanced Statistics in Neuroimaging & Genetics! Today-tomorrow I'm teaching longitudinal & Bayesian modeling in neuroimaging to a stellar group of students. medicine.utah.edu/psychiatry/a...

Our new study in Molecular Psychiatry, in 1528 children and their parents (@ntrbiopsy.bsky.social) shows that indirect genetic effects—where parental genetics shape offspring traits via environmental influences (genetic nurture)—impact DNA methylation of children. doi.org/10.1038/s413... (1/5)

Intergenerational transmission of complex traits and the offspring methylome - Molecular Psychiatry

Molecular Psychiatry - Intergenerational transmission of complex traits and the offspring methylome

doi.org

On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...

Reminder: We hope you will join us TODAY for a timely and important Member’s Meetup regarding the federal changes and updates affecting the NIH. 📅 Wednesday, January 29 🕗 3 PM EST 📍 us06web.zoom.us/meeting/regi... #psychiatry #psychiatricgenetics

Unsure how recent changes in U.S. policy regarding the NIH will impact the psychiatric genetics world? You're not alone. Join ISPG for a Member’s Meetup for community discussion and support: 📅 Wednesday, January 29 🕗 3 PM EST 📍 Pre-Register: us06web.zoom.us/meeting/regi...

📢 Quantgen friends: We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁 Check out our latest program and apply now! www.grc.org/quantitative...

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social. www.cell.com/cell/fulltex... A thread 🧵:

📚 Bias in Faculty Promotions A @natureportfolio.bsky.social study of 1,571 staff at US universities revealed underrepresented minorities face tougher standards. They received 7% more negative votes & their research was judged more harshly. 🔗 www.nature.com/articles/s41... #SciComm 🧪 #HigherEd

Underrepresented minority faculty in the USA face a double standard in promotion and tenure decisions - Nature Human Behaviour

Masters-Waage et al. report that underrepresented minority (URM) faculty in the USA face barriers in the promotion and tenure process, receiving more negative votes and fewer unanimous positive decisi...

nature.com

🚨Call for submissions!🚨 We're organizing a special issue on "Behavioral Genetics as a Public Science"🧬🌍 Relevant topics include: -Public outreach and education -(Mis)use and (mis)interpretations of BG research -Ethical, legal, and social issues tinyurl.com/bgpublicscie...

Call for Submissions: Behavior Genetics Special Issue on Public Science

Call for Submissions: Behavioral Genetics as a Public Science: Impacts and Implications Journal: Behavior Genetics Aim and Scope: Genetically informed studies of human behavior captivate a broad a...

tinyurl.com

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...

Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance

Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...

biorxiv.org

New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...

Characterizing the genetic architecture of drug response using gene-context interaction methods

Sadowski et al. propose a framework to study the genetics of response to commonly prescribed drugs in large biobanks. They quantify the heritability of response to statins, metformin, warfarin, and methotrexate, and identify associated genes. Their analysis also shows the importance of accounting for drug use in genetic risk prediction.

cell.com

WHO just released the new principles for ethical collection and sharing of genomics data www.who.int/news/item/20...

WHO releases new principles for ethical human genomic data collection and sharing

The World Health Organization (WHO) has issued a set of principles for the ethical collection, access, use and sharing of human genomic data. Created with guidance from the WHO Technical Advisory Grou...

who.int

My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.

Examining the role of common variants in rare neurodevelopmental conditions - Nature

Patients with neurodevelopmental conditions without a monogenic diagnosis have a higher polygenic burden than those with a monogenic diagnosis. Non-transmitted common all...

nature.com

Emilie Wigdor@emiliewigdor.bsky.social · 2y ago

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣 Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...