I have fallen into the depths of summer paper land, where I only exist to review other articles and respond to reviews for my articles, and somehow still ACS has decided that I have to log in in the most roundabout way to their main website before going to the pub center #rude

Thoughts on the various Trump administration proposals to revamp US science funding - and what they all have in common:

The Assault On Science Funding Continues

science.org

Excited to see this collaboration now in print. Dye chemistry meets AI-designed proteins. Three small, orthogonal tags; lifetime modulation; split versions. Request the free dyes at dyes.janelia.org www.science.org/doi/10.1126/...

De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging

Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...

science.org

Our department is hiring! We teach and do research with undergraduates exclusively. For a PUI, we have very good facilities and instrumentation (400 MHz NMR, six MS). Great colleagues and students — about 1/3 of majors go on to Ph.D. #chemsky @chemjobber.bsky.social jobs.cofc.edu/postings/18244

New: The National Science Foundation is preparing to claw back some $500 million in funds from some of its core science programs in physics, math, computer science, and engineering in order to fund a project from the White House Office of Science and Technology Policy.

NSF plans cuts to core science programmes to fund White House initiative

A proposed clawback of already distributed research funds comes as the US agency’s budget is already squeezed and it struggling to clear a backlog of grant applications.

nature.com

We're not done friends. See thread. Comment on the NSF proposal, contact your reps!

Mark Peifer (He, him)@peiferlabunc.bsky.social · 3w ago

Let's learn a lesson from the nearly 500K of us who mobilized to comment on the OMB rules. We can leave the sidelines, take action and it can make a difference. After 15 months of inaction, our scientific societies finally woke up and mobilized members. It doesn't stop there 1/n

cutting pure science to prioritize applications is fundamentally like asking farmers not to waste time producing grain, cheese, and tomatoes and focus on making pizzas

We are on a roll! Yet another paper from the group. Learn how biomolecular switches may profit from operating in a correlated manner, e.g. by being in contact with the same environment in a work by Rudi, Daniel and Giovanni. journals.aps.org/pra/abstract... #Quantum @quantumbiology.bsky.social

Photoswitchable optoGPCRs for reversible control of Gs and arrestin signalling www.biorxiv.org/content/10.64898/2026.07.01.735182v1

I love everything about this editorial by @dereklowe.bsky.social. Silence won't save anyone in the end. www.science.org/content/blog... "So the CEOs have decided to lie very still and hope that no one notices them.... But will it work? Only so long as Trump and his creatures see a benefit in it..."

Speaking Up: Who Is, and Who Isn't

science.org

🟧 Orange is the new green?? 🟧 New sensitive orange calcium indicator (🟠OCaMP) now out in Nature Comms: www.nature.com/articles/s41... Highlights ⚡ Detects single action potentials in vivo 🔬 Optimized for 1030 nm imaging 📸 Highly photostable, minimal photoswitching 🌈 Multiplex with green biosensors

A new paper presents CANVAS, a computational workflow that converts minimal de novo TIM barrels into enzymes by designing structural lids that generate tailored active sites www.nature.com/articles/s41...

Customizing the structure of minimal TIM barrels to craft efficient de novo enzymes - Nature Chemical Biology

The TIM barrel is nature’s most versatile enzyme fold, yet de novo variants lack functional active sites. Minimal de novo TIM barrels have now been converted into enzymes by designing structural lids ...

nature.com

A [Cu-4Fe-4S] cluster? Yep, you read that right! We report a new bioinorganic motif in an acetol dehydrogenase and characterized it with our wonderful collaborators from @ribesresearch.bsky.social @lmu.de @cutsail-lab.bsky.social @ksgchem.bsky.social @mpi-mr.bsky.social @hhu.de 🧪 #chemsky

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 2mo ago

An Unprecedented [Cu 4Fe 4S] Cluster in a Methanotroph Acetol Dehydrogenase https://www.biorxiv.org/content/10.64898/2026.06.11.731722v1

Something that has improved my powers of concentration/getting stuff done enormously--getting a small MP3 player that only has music I like, doesn't pause for ads, doesn't require internet, is tiny enough to live in my pocket, etc. Most important: it's NOT my phone

Just got a notice of award for an R01. I will be hiring. I'll be looking for either a staff scientist or postdoctoral researcher. The project explores the conserved HEATR5 family of proteins. Their roles in AP1 mediated traffic, and links to motors.🎉

Want to compare different LLMs on extracting chemical data from papers? Check out LoA! Paper: pubs.acs.org/doi/10.1021/... Github/Jupyter/Docker: github.com/arwalkerlab/... #compchem #chemsky

Dear colleagues, PLEASE submit a comment against OMB's proposed rule. Elizabeth wrote great guide on drafting a comment. To submit it, go to www.regulations.gov/search and search for OMB-2026-0034. It will take time & effort to write a good comment, but a worthwhile effort to save our profession.

elizabethginexi.bsky.social@elizabethginexi.bsky.social · 2mo ago

Calling all Scientists! Research Administrators! Deans! Fans of Science! No one is coming to save us. Here is your assignment. I have written a step by step, easy to understand "how-to" document to help you comment on the proposed OMB rule. elizabethginexi.substack.com/p/what-we-ne...

hey #chemsky / #compchem - "molecular dynamic simulations" or "molecular dynamics simulations"? I always thought it was the second one but I keep seeing the first and becoming unreasonably irked

#postdoc position in our lab explore.jobs.ufl.edu/en-us/job/53...

Ukrainian 🇺🇦 embroidery, known as vyshyvanka - organic chemistry edition #chemsky

🚨 New preprint from the Feigin Lab! 🚨 www.biorxiv.org/content/10.6... Opioids have profound effects on the pancreatic cancer microenvironment! An FDA-approved opioid antagonist that doesn't cross the blood brain barrier decreases tumor aggressiveness in a mouse model of pancreatic cancer!

First author, Andrea Batchev’s paper: “Cyclen Tetra‐Amide Ligands as a Privileged Class of Ligands for Studying Second‐Sphere Coordination Environments The paper is a collaboration between the Allen and Walker Labs at #wsuchemistry. #ChemSky chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Cyclen Tetra‐Amide Ligands as a Privileged Class of Ligands for Studying Second‐Sphere Coordination Environments

Cyclen tetra-amide derivatives provide a privileged ligand platform for controlling second-coordination sphere structure. Hydrogen-bond networks in the second-coordination sphere are leveraged to sta...

chemistry-europe.onlinelibrary.wiley.com

A Spectrum of Possibilities: A Systematic Evaluation of Fluorescent Proteins in Cyanobacteria by Anna Behle and team: www.biorxiv.org/content/10.6...

Please share widely. The new (simpler) MIRA R35 for Early Stage Investigators (ESI) NOFO is published. First due date is 10/2/2026. files.simpler.grants.gov/opportunitie...

We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...

Wonderful opportunity to hear about the latest progress in fluorescent probe technology ⬇️

Janelia Conferences@janeliaconf.bsky.social · 6mo ago

📢 Applications are open! Join us in October to explore next-generation fluorescent proteins, biosensors & imaging advances + machine learning and computational approaches to accelerate design. 🛏️ Meals & lodging covered; no registration fee Apply by May 21 ➡️ janelia.news/FPS26 @agtebo.bsky.social

Happy to share how low-barrier hydrogen bonds power PCET reactions in metal-free RNRs - now out in PNAS! So proud of my lab & for great collaboration w Heberle, Kasanmascheff & Högbom Labs. Thank you @kawresearch.bsky.social for long-term support of our research! www.pnas.org/doi/10.1073/...