Audrey Desgrange

@audreydsg.bsky.social

Permanent researcher at INSERM. Working at Institut Imagine and Institut Pasteur (Paris, France). Morphogenesis addict. L’Oréal UNESCO FWIS ambassadress

Very happy to share our latest paper identifying Notch3 as a new left gene required for #heart #morphogenesis 💜 Many thanks to all the authors!

PLOS Biology@plosbiology.org · last yr.

Creating an asymmetric heart: @tbonnely.bsky.social @audreydsg.bsky.social @meilhacsigolene.bsky.social &co identify Notch3 as a novel asymmetric factor in lateral plate mesoderm that acts as a genetic modifier of NODAL to regulate #heart #morphogenesis @plosbiology.org 🧪 plos.io/42q6H4L

Left: Expression of Notch3 (white) detected by whole mount RNAscope ISH in an E8.5d wild-type embryo, shown in frontal views (top, cranial part of the embryo) and transverse section (bottom). Filled and empty arrowheads point to high and low expression, respectively. Right: Segmentation of the cardiac region in 3D images, to quantify gene expression in the left (white) or right (yellow) heart field. The heart tube is colored in red. Somites are outlined by white dotted lines. Expression of Notch3 within the segmented second heart field is extracted in the right panel.

📣 Journée internationale des femmes et des filles de science à l'Institut Imagine ! Nous célébrons aujourd'hui toutes celles qui, par leur passion et leur détermination, font avancer la recherche et l’innovation : cette journée permet de mettre en lumière leur parcours, parfois semé d’obstacles.

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🧬 Join Institut Imagine as a Junior Group Leader! - Junior Group Leader in Systems and Computational Biology - Junior Group Leader in RNA Biology and Epigenomics - Junior Group Leader in Artificial Intelligence for Genetics, Biology & Medicine To submit your application : lnkd.in/enm-U2tH

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🚨 Postdoc wanted 🚨 Ever wondered how mechanical forces shape the heart tube during embryogenesis?… I am looking for a postdoc with a background in developmental biology or biophysics to investigate this new topic as part of an ANR-JCJC 🚀🔬 Don’t hesitate to contact me 🤓🔗

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