Pratiti (Mimi) Bandopadhayay
@bandolab.bsky.social
www.bandolab.org Genomic approaches for childhood brain tumors Pediatric Neuro-Oncologist/Scientist @DanaFarber, @Broadinstitute, @BostonChildrens Views are my own
Join researchers working on pediatric cancer at @dmmjournal.bsky.social's meeting in October at Nationwide Children’s Hospital, USA. Organisers: James Amatruda @amatrudalab.bsky.social, Pratiti (Mimi) Bandopadhayay @bandolab.bsky.social , Ana Banito & Elaine Mardis Register at tinyurl.com/bddksc4v
We have a fantastic line up of speakers for our 2026 Journal Meeting organised by @amatrudalab.bsky.social, @bandolab.bsky.social, @banitolab.bsky.social and Elaine Mardis @nationwidekids.bsky.social! 🚨Register your interest now so you're first to get updates🚨 www.biologists.com/meetings/dmm...
Daniel Nomura, David McFadden, Kimberly Stegmaier, and Pratiti Bandopadhayay will discuss "Discovery of New Targets With Functional and Chemical Genomics" in a plenary at the AACR Conference on Fusion-Positive Cancers (January 13-15; Philadelphia). buff.ly/S2biIJv #AACRfusion26 @bandolab.bsky.social
This was a fun project with John Rhee and Charlotta Lindvall on using LLMs to scour medical records. It has been wonderful to work with them! secure-web.cisco.com/1QgAtJ9SFoCj...
Scalable Tracking of Symptoms in the Electronic Health Record using Large Language Models in Patients with Central Nervous System Cancers Undergoing Therapy
AbstractBackground. Advances in large language models (LLMs) provide a means for scalable tracking of patient symptoms in clinical trials and post-marking
secure-web.cisco.com
Everyone needs to watch this. Our children deserve better. They need MORE funding, resources and research. Not less. lnkd.in/gevV3Gth
#pediatriccancerawareness | René Marsh
Federal funding for a pediatric brain cancer network of top doctors, scientists and hospitals across the country is being cut. Health and Human Services tells CNN the cut is for efficiency. The Pedi...
lnkd.in
Excited to get this out there as we go through revisions. These findings have changed how I think about KIAA1549-BRAF of pediatric gliomas, and all other fusions, completely. The fusion partner is important, necessary and engenders novel vulnerabilities that can be therapeutically targeted.
Adnan Halim@handle.invalid · 12mo agoTogether with @glyco.me, @bandolab.bsky.social and teams, we recently uncovered a link between pediatric brain tumors, POMT1/2 enzymes and KIAA1549 - full story in the preprint below: www.biorxiv.org/content/10.1...
Terrible news for pediatric brain tumor research and incredible amount of hard work wasted. This very likely will result in some active trials prematurely closing without sufficient accrual to answer their aims.
Pratiti (Mimi) Bandopadhayay@bandolab.bsky.social · 12mo agoDevastating news. The Pediatric Brain Tumor Consortium has lost its ability to apply for federal funding upon which it is structured. Without this, it cant exist. This threatens access to clinical trials for children. These children need MORE funding and MORE trials, not less. They deserve better
Every dollar invested by the federal government on health research returns $2.60 in economic activity, not to mention the benefits to our health. The federal government spends very little on biomedical research as it is; it is so counterproductive to cut what remains. ☹️
Devastating news. The Pediatric Brain Tumor Consortium has lost its ability to apply for federal funding upon which it is structured. Without this, it cant exist. This threatens access to clinical trials for children. These children need MORE funding and MORE trials, not less. They deserve better
Excited to share our paper reporting significance of FGFR-alterations across pediatric gliomas. Congratulations April Apfelbaum and Eric Morin and to everyone across our labs and collaborators. Thank you to the foundations and patients/ families who made this happen. www.bandolab.org rdcu.be/eyHcG
A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
Nature Communications - A subset of pediatric gliomas harbour alterations in fibroblast growth factor receptor (FGFR)-family proteins. Here, the authors characterise the genomic landscape of 11,635...
rdcu.be
Excited to be part of the editorial team for the FIRST journal specifically focused on pediatric brain tumors. Submissions now open!
EANO@eanoassociation.bsky.social · last yr.💪Neuro-Oncology Pediatrics – a new open access journal by EANO & @neuroonc.bsky.social for the global #pediatric & AYA #NeuroOncology community. Now open for submissions! 🔗 academic.oup.com/neuro-onc-peds Editor-in-Chief: S. Mueller Executive Editors: M. A. Roldán (EANO), @bandolab.bsky.social (SNO)
An inspirational (and fun) few days of science at the joint Bando-Beroukhim-Ligon Labs retreat in Maine. Joined by Nada Jabado, Claudia Kleinman and Veronica Rendo. We are all on the mission together to find better treatments for our kids #BandoLab
A fun project with @rameenberoukhim.bsky.social and @vrendo.bsky.social focused on how the interplay between structural variants at the BRD4 locus fine tunes its expression. Congratulations to Jeremiah, Simona, Sophie and team, and also to Veronica! Looking forward to many more collaborations ahead.
Veronica Rendo@vrendo.bsky.social · last yr.📣 Online now! Our study shows how recurrent focal deletions constitute a mechanism by which cancer cells can dampen toxicity due to gene amplification. www.cell.com/cell-genomic... 🧵👇:
Congratulations to @vrendo.bsky.social. Very excited for the amazing science that is still to come from the Rendo Lab for our kids with brain tumors
Veronica Rendo@vrendo.bsky.social · last yr.Today we celebrated my official Group Leader appointment and paper publications with bubbles and prinsesstårta, the Swedish way! 🍰🥂🍾 Skål!
The Bando and Beroukhim Labs (www.bandolab.org, www.beroukhimlab.org) are seeking a Senior Scientist to help find better treatments for children with brain tumors. More details here: careers.dana-farber.org/job/11089/sr... @rameenberoukhim.bsky.social #BandoLab #DFCI @broadinstitute.org
Research Laboratory Job: Sr Scientist - Bandopadhayay Lab at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA
Sr Scientist - Bandopadhayay Lab job
careers.dana-farber.org
So excited to see this paper out! An example of how window of opportunity trials can help dissect the mechanisms of response and resistance associated with targeted therapies in glioblastoma 🧠 www.science.org/doi/10.1126/... Thanks to the patients and scientific team who made this study possible.
A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma
In patients with glioblastoma, navtemadlin resistance is not mediated by TP53-inactivating mutations, and combination with TMZ may improve efficacy.
science.org
With an aim to drive collaborative team science & in honor of our remarkable #CARTcell patients, we started the annual Cleveland Hood Lecture w/ Dr Neev Manoharan of Sydney Children’s Hospital as our inaugural speaker. It’s a privilege to build intercontinental alliances against childhood cancer ❤️🔬
Congratulations to @johnprensner.bsky.social and the entire team!
John Prensner@johnprensner.bsky.social · 2y agoLooking to see how #RiboSeq can improve your cancer research? Check out how we've been developing new methods to study #medulloblastoma and other forms of #childhoodcancer. Out in @naturecomms.bsky.social now. Thanks to Jim Clauwaert and Gerben Menschaert as well! www.nature.com/articles/s41...
Honored to have our recently published first-in-human phase 1 clinical trial of repeatedly dosed intracerebroventrocular B7-H3 #CARTcells for children with #DIPG highlighted in @theaacr.bsky.social and #CancerDiscovery Research Watch ❤️🔬
BrainChild-03 Trial Supports Safety of B7-H3 CAR T-cell Therapy for DIPG
Main Finding: A phase I trial supported the safety and feasibility of repeated intracranial infusions of B7-H3 CAR T cells for DIPG.Concept: B7-H3 is an immunoregulatory protein expressed on the surfa...
aacrjournals.org
Proud to share this preprint on behalf of Nico, Daren and team with some insights that we hope will be helpful to those modeling K27M mutations in histone proteins. #BandoLab www.biorxiv.org/content/10.1...
N-terminal modification of Histone H3 inhibits H3K27M-mediated loss of H3K27 trimethylation
The use of short epitope tags is widespread in the study of histone H3 biology as they allow for the antibody-mediated detection and pulldown of particular histone post-translational modifications (PT...
biorxiv.org
Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this! So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work! www.cell.com/molecular-ce...
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.
cell.com
A proud mentor moment! Congratulations to Jenna! We are so excited to have you in our team and working for children with brain tumors to find more effective and less toxic treatments. Www.bandolab.org @broadinstitute.org #DFCI #SNO2024 #ISPNO
#SNO2024…… my first BlueSky meeting! Excited to connect with friends, colleagues and collaborators and brainstorm around our projects focused on pediatric brain tumors. Www.bandolab.org #teamscience #PedBrainTumors #BandoLab #DFCI @broadinstitute.org We are on this mission together
Our Blue Skies repost of April and Eric's preprint, on behalf of the www.bandolab.org, Ligon Lab, David Jones, and collaborators, focused on FGFR-alterations in pediatric gliomas. #TeamScience #PedBrainTumors @broadinstitute.bsky.social #DanaFarber @dkfz.bsky.social www.biorxiv.org/content/10.1...
A diverse landscape of FGFR alterations and co-mutations defines novel therapeutic strategies in pediatric low-grade gliomas
Alterations in Fibroblast growth factor receptor (FGFR)-family proteins frequently occur as oncogenes in many cancers, including a subset of pediatric gliomas. Here, we performed a genomic analysis of...
biorxiv.org
Hello to the Blue Sky community! Excited to join on behalf of www.bandolab.org! We are on a mission to find more effective and less toxic treatments for children with brain tumors
Bandopadhayay Lab at Dana-Farber Cancer Institute
The Bandopadhayay Lab applies genomics to characterize driver alterations that contribute to pediatric brain tumor formation and to develop strategies to therapeutically target them.
bandolab.org
