IL-6-induced C/EBPα drives follicular regulatory T cell differentiation to regulate humoral immunity in mice @natcomms.nature.com www.nature.com/articles/s41...

TGF-β and IL-2 differentially shape T follicular regulatory cell differentiation and stability in vitro www.nature.com/articles/s41...

Super excited to see our newest study on in vitro-generated Tfr cells published in Cellular & Molecular Immunology. Check it out for free: www.nature.com/articles/s41.... Fantastic work by first-author Luisa Bach and our colleagues & collaborators. @immunosens.bsky.social @unibonn.bsky.social

A decade ago we showed that T-dependent IgM+ memory B cells (MBCs) that express CD80 and CD73 rapidly respond to a secondary Plasmodium infection (Krishnamurty, Immunity, 2016). Since then, post-doc Gretchen Harms Pritchard has been working out the cues that lead to the formation of these cells. ⤵️

Journal of Experimental Medicine@jem.org · 2mo ago

Harms Pritchard, @marionpepper.bsky.social et al. dissect key CD4⁺ T cell/B cell interactions to define signals that govern the development of memory B cell populations. rupress.org/jem/article/... #InfectiousDisease #HostDefense #LymphocyteBiology #BCells

Schroeder, Zhu, Xia, and Hu show that, depending on the immunization route, location, and antigen dose, BACH2 exerts bidirectional regulation on the differentiation of CXCR5− versus CXCR5⁺ CD4⁺ T cells, orchestrating systemic immunity throughout the body. rupress.org/jem/article/...

Tumor-draining lymph nodes lack active germinal centers and instead harbor quiescent tumor-reactive memory B cells, serving as memory reservoirs supporting intra-tumoral immunity @cp-immunity.bsky.social www.cell.com/immunity/ful... @zivshulman.bsky.social @weizmanninstitute.bsky.social

📣EFIS - Immunology Letters Study Group “T Cell Connect Europe” Monthly Immunology Lecture Series focusing on #Tcellbiology and T cell-mediated immunity! 💡Two 25 minute lectures + 10 minutes discussion 📅Next lecture: June 2, 2026. 🎙️Presenters: Axel Kallies & Adrian Hayday. 🔗 www.t-cells.eu

Looking forward to two exciting talks by Massimiliano Pagani (Milan) and Daniela Latorre @lablatorre.bsky.social (Milan) in the @efis-immunology.bsky.social EFIS-IL study group T-Cell Connect Europe online lecture series TODAY at 5pm CET. Details: www.t-cells.eu

🧭 ... two weeks left to submit your abstracts for the 55th Annual Meeting of the German Society for Immunology www.immunology-conference.de/scientific-p... All accepted abstracts will be published in the @eurjimmunol.bsky.social @efis-immunology.bsky.social @dgfi-yi.bsky.social

In this review, Adam, Suhail, Kuchroo, and Vignali highlight the challenges and novel approaches to developing agonistic inhibitory receptor (IR)-targeted therapies to treat #autoimmunity and inflammatory disorders. rupress.org/jem/article/... #CancerFocus #LymphocyteBiology

Perinatal infection elicits clonally restricted T follicular helper cell responses that drive antibody-mediated viral control @cp-immunity.bsky.social @unibas.ch www.cell.com/immunity/ful...

Ettal 💐 Spring School 2026: Deep Dives into Current Concepts in Immunology #dgfispringschool 30 leading speakers and 63 participants from nine countries explored cutting edge immunology. @efis-immunology.bsky.social @yefis-immunology.bsky.social @drfzberlin.bsky.social @dgfi-yi.bsky.social

I had an absolutely fantastic time at the 21st @dgfi-org.bsky.social Spring School in Ettal, Bavaria, Germany. It was a true pleasure discussing with the incredibly talented students and postdocs. Thank you to the organizers for the kind invitation and the superb organization! #dgfispringschool

I'd like to see this problem analysed at the single cell multi-omics level 'Advances in research technolo- gies are crucial for the scientific enterprise but have an unintended consequence: when pow- erful techniques become widely available, they tend to be applied without a good question in mind.'

On the balance of knowledge - Nature Reviews Immunology

Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

nature.com

Great news—We remain the most successful German University of Excellence! With eight Clusters of Excellence and funding secured until 2033, we’re moving closer to our goal of establishing our Uni permanently among the best universities in the world: www.uni-bonn.de/en/news/040-... © VL/Uni Bonn

Looking forward to two exciting talks by Jens Geginat (Milan) and Ralf Schmidt (Vienna) in the @efis-immunology.bsky.social EFIS-IL study group T-Cell Connect Europe online lecture series TODAY at 5pm CET. Details: www.t-cells.eu

Excited to organize @keystoneSymposia.bsky.social Tissue and Spatial Immunology with @leilaakkari.bsky.social and Hai Qi in February 2027! Join us to explore emerging research in Banff! keysym.us/KSSpatialImmune27 #KSSpatialImmune27

Tissue and Spatial Immunology | Keystone Symposia

Join us at the Keystone Symposia on Tissue and Spatial Immunology, February 2027, in Banff, with field leaders!

keysym.us

Our workflow to image and analyse germinal centres using a 50-plex cyclic staining protocol now out. Work led by Isabel San Martín Molina & Edith Marcial Juárez with @babrahaminst.bsky.social imaging facility scientists Simon Walker & Hanneke Okkenhaug. onlinelibrary.wiley.com/doi/10.1002/...

Spatial Profiling of Germinal Centers in Mouse Secondary Lymphoid Organs Using MACSima Imaging Cyclic Staining Technology

We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, a...

onlinelibrary.wiley.com

Ever wondered what happens if you remove Tfh cells from established germinal centres?

Thrilled to share our latest work: Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - now online in Nature Immunology. Led by Alberto Conti, Alex Evans and Teresa von Linde in the lab. www.nature.com/articles/s41...

Finally, my PhD project is published! 🎉 I am thankful to all the collaborators who made this possible! www.nature.com/articles/s41... @natcomms.nature.com #dendriticcells #immunesynapse #centrosome

Looking forward to two exciting talks by @carovinuesa.bsky.social and Dirk Elewaut in the EFIS-IL study group T-Cell Connect Europe online lecture series TODAY at 5pm CET t-cells.eu

@biorxivpreprint.bsky.social Dysregulated localization of Tfh and B cells in lymph nodes of Idiopathic multicentric Castleman disease patients www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social

🚀 New preprint! The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab! 🔗 www.biorxiv.org/content/10.6...

🎉 The new yEFIS website is now live! 🌐 We’re happy to share that our new website is officially online, check it out 👉https://www.yefis.org/

@biorxivpreprint.bsky.social Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responses www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social BCL6 is required for the development of functionally responsive IgM+ GC-independent Memory B Cells @marionpepper.bsky.social www.biorxiv.org/content/10.1...

The Cluster Science Days 2025 were a very joyful event bringing together our Bonn scientists to share ideas and to network. During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.

@natrevimmunol.nature.com Guidelines for T cell nomenclature www.nature.com/articles/s41...