Pleased to share results from the CAcTUS Phase II trial of ctDNA-guided therapy in BRAF-mutant advanced melanoma are now published! 🌵🧬 CAcTUS is the first melanoma trial to adapt treatment based on ctDNA testing. Read: www.nature.com/articles/s41...

OpenSAFELY is open from today! Huge thanks to all who supported this vast collaboration: whole population GP data; in a productive platform; innovative privacy protections; unprecedented support from professions, privacy campaigners; &c Now it's over to users! www.bennett.ox.ac.uk/blog/2026/02...

OpenSAFELY news: you can apply to do non-COVID research, from today! | Bennett Institute for Applied Data Science

We are delighted to announce that - from today - you can submit applications to the OpenSAFELY service for non-COVID-19 studies.

bennett.ox.ac.uk

www.deadlanguagesociety.com/p/how-far-ba... I cannot speak as to the accuracy of the piece yet I found it a fascinating exercise @adamroberts.bsky.social @drlauravarnam.bsky.social

How far back in time can you understand English?

An experiment in language change

deadlanguagesociety.com

👉...cutting-edge science, clinical insights & discussions re: real-world implementation of TIL therapy. Featuring keynote speakers: Inge Marie Svane 🇩🇰 & Sebastian Klobuch 🇳🇱. @sklobuch.bsky.social @debrajosephs.bsky.social @turajliclab.bsky.social @beckilee.bsky.social

Exciting conference alert! sites.manchester.ac.uk/from-lab-to-... Fantastic speakers including Chris Marine, Christian Blank Melanoma evolution Local microenvironment of melanoma Melanoma-host interactions Precision immunotherapy Emerging therapeutics Clinical trials and real-world data

🩺 Fantastic opportunity for #YoungOncologists: ICF-ESMO programme for an 8-week observership. We've excellent opportunities here in Manchester & would be happy to support (✉️: the-christie.observers@nhs.net). @christieinstitute.bsky.social @myesmo.bsky.social 📥 For more info (due 25 Jan 2026) 👇

Excited about not one but 2 fantastic conferences in Manchester! So timely as cell therapies are on the standard care horizon!

Jon Lim, FRCP PhD@drjonlim.bsky.social · 8mo ago

...and don’t miss our TIL Summit 2026, taking place the day before (11 Mar 2026), also at the Midland Hotel. A dedicated forum bringing together UK & international leaders to discuss TIL therapy, manufacturing, biomarkers, and next-generation trials 👇

⏰ Calling all melanoma enthusiasts! The abstract submission deadline for the inaugural “Lab to Life: Innovations in Melanoma Research Conference UK 2026” has been extended to 19 December 2025! Happening 12-13 March 2026 at The Midland Hotel, Manchester. Submit your abstract and register here:

Home

Lab to Life: Innovations in Melanoma is a UK conference in Manchester on cutting-edge melanoma research, translational science and advances in treatments.

sites.manchester.ac.uk

Cancer detectives a hit in our house! Bench to bedside look at the DETECTION trial- Inspiring scientists of the future and an insight into why science is important, the breakthroughs they fund and what it means to the people involved www.channel4.com/programmes/c...

Happy Halloween from these two!

Melanoma UK today visited the Smiths Melanoma hub today learning about the amazing work all of these lovely people are doing! Thanks for funding us! @mcrcnews.bsky.social

Attending #ESMO25 Join us to learn about sustainability integration into cancer care and the environmental impacts of AI 👇 @myesmo.bsky.social @robchuter.bsky.social @beckilee.bsky.social @pawelsobczuk.bsky.social @ouchinternational.bsky.social @irishdocsenv.bsky.social @cancertrialsie.bsky.social

Amazing work throughout the UK to smash our recruitment target!

Southampton Clinical Trials Unit@southamptonctu.bsky.social · 10mo ago

Congratulations to the DETECTION-2 team for reaching this recruitment milestone! This #ClinicalTrial is seeing if a simple blood test can detect #melanoma returning earlier than a routine scan. A larger phase III trial is now being planned. Read more - bit.ly/3YRtqok @cancerresearchuk.org

We are pleased to announce the publication of our STEMM sector-wide survey The report highlights our findings & suggests recommendations. Now available to download here carersinstemm.co.uk Please share especially w/ institutions, funders & allies @laurawolz.bsky.social @carterlj.bsky.social

NEW: Nature trained AI to predict which NIH grants from 2014 would have been cut if the Trump admin had its way back then — and what science would have been lost to history. "The results show the damage that cuts in funding can do to research, and the unpredictable nature of the research process."

Nature@nature.com · 10mo ago

We used machine-learning tools in an attempt to recreate the method for cutting funding, and then applied it to past US NIH grants to reveal the broad-reaching consequences go.nature.com/4pBArFH

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Very pleased to say DETECTION2 has just randomised it's 50th patient! Awesome work by patient groups @melanomafocus.bsky.social , UK clinical teams @christieinstitute.bsky.social R+I and SCTU funded by @cancerresearchuk.org

snoopy is standing in front of a fireworks display and says `` congratulations ! ''

Alt: snoopy is standing in front of a fireworks display and says `` congratulations ! ''

media.tenor.com

v1.108 is rolling out today 🚚 Now live, at long last: Bookmarks, aka Saved Posts. For all those posts you'll definitely plan to come back to! Update the app and give it a try. The button is right down there 👇

The Lee lab is expanding! We are really interested in mechanisms of local and systemic immune tolerance particularly in liver metastases - X2 research technicians 💡 Creative fun environment 🌱 Opportunities to grow 🫂 Highly collaborative with clinical+basic research 📢 Please spread word!

Research Technician:Oxford Road

jobs.manchester.ac.uk

Calling all ECRs in cancer and metastasis research. Don't forget to register for the upcoming ECR Virtual Symposium in November (FREE for MRS members). More details here metastasis-research.org/2025/08/06/2...

⭐We have a clinical fellow opportunity with the melanoma team! ⭐ Very friendly and supportive team Lots of learning opportunities including clinical trials and immune therapy Apply here👇 urldefense.com/v3/__https:/...

🚨 Exciting new paper alert 🚨 From the Marie lab ⭐They have identified new melanoblast cell states which are reawakened in metastasizing and immunotherapy resistant melanoma ⭐ Can target using hdac inhibitors #melsm #melanoma #cancer www.biorxiv.org/content/10.1...

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

Melanoma plasticity, driven by phenotype state switching, underlies clinically relevant traits such as metastasis and therapy resistance. As melanoma progression is thought to recapitulate aspects of ...

biorxiv.org

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

nature.com

Mathematical models and ctdna have reached the clinic - the ultimate personalised trial testing adaptive targeted therapy highlighted in the news today! #EBEcancer25 www.express.co.uk/life-style/h...

UK cancer breakthrough as simple blood test could help pinpoint treatment

EXCLUSIVE: Skin cancers can be among the most aggressive forms of the disease so using drugs to shrink them must be used with precision.

express.co.uk

Absolutely loving this course - fantastic discussions between all and the delegates and faculty. So many exciting Q's coming out of this!

Trevor Graham@trevorgraham.bsky.social · last yr.

Now medical oncologist and clinician scientist @beckilee.bsky.social leading the first clinical session. Discussing how to bring evolutionary and ecological ideas into molecular tumour boards, and how to design evo clinical trials for better treatment regimens. #EBEcancer25 @eventswcs.bsky.social

Excited to share our new study on how resistance to AKT inhibition is linked to lineage differences within breast cancer 👇🏽 Stellar work @colindhratcliffe.bsky.social www.biorxiv.org/content/10.1... and also surprisingly/worryingly good AI generated podcast 🎧 notebooklm.google.com/notebook/28e...

The deadline for early bird registration for the 5th Crick Cancer Conference has been extended. See the full programme and book by 15 July to take advantage of reduced ticket rates for early bookers ⤵️ www.crick.ac.uk/whats-on/5th...

5th Crick International Cancer Conference

crick.ac.uk

Super proud of our fellow Tomasso Bosetti presenting his poster at #ASCO25 on the impact of timing of immune therapy and outcomes across cancers - the early 🐦catches the 🪱!

Our data and the lung cancer trial also presented are very compelling for early time of day immune therapy treatment urldefense.com/v3/__https:/...

Sarah Danson@sdanson1.bsky.social · last yr.

This is fascinating. When paired with the Manchester abstract @beckilee.bsky.social and colleagues presented, do we need to change practice now?

Single cell whizz with green fingers for molecular genomics? Want to develop and apply new technologies for profiling #cancer #evolution? Like single cell WGS + ATAC: www.biorxiv.org/content/10.1... Perhaps our senior scientific officer role is for you? jobs.icr.ac.uk/vacancies/12... @icr.ac.uk

Higher or Senior Scientific Officer in Sutton | The Institute of Cancer Research

View details and apply for this Higher or Senior Scientific Officer vacancy in Sutton. Salary : Salary from 39,805 to 49,023 Reporting to: Prof Trevor Graham Duration of ...

jobs.icr.ac.uk