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Mikala Egeblad

@megeblad.bsky.social

Bloomberg Distinguished Professor of Tumor Microenvironment. Johns Hopkins University School of Medicine.

69 Posts2277 Follower348 Folgt
Aguirre-Ghiso Lab@jaguirreghisolab.bsky.social · last yr.

Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

nature.com

Max Kozlov@maxkozlov.bsky.social · last yr.

Hidden in the lungs of some breast cancer survivors are tumor cells that can remain dormant for decades — until they one day trigger a relapse. Now, experiments show for the first time these rogue cells can be roused from their slumber by common respiratory illnesses such as COVID-19 or the flu.

‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu

Inflammation from the respiratory infections seems to be the culprit, study in mice finds.

nature.com

Hannah Meyer@hannahvmeyer.bsky.social · last yr.

Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!

T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database

Banerjee et al. present a comprehensive T cell receptor cross-reactivity database and a hierarchical Bayesian framework to predict T cell receptor targets. Together, they reveal structural and biochem...

cell.com

JHU Bloomberg Distinguished Professorships@jhu-bdps.bsky.social · last yr.

A fascinating study reports that neutrophils and NETs actively induce tumor necrosis. Congratulations, BDP @megeblad.bsky.social and @adrover.bsky.social on your latest publication in @nature.com.

Mikala Egeblad@megeblad.bsky.social · last yr.

As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis. 🔗 www.nature.com/articles/s41... @jhu-bdps.bsky.social @nature.com

Aaron J. Waltke@goodaaron.bsky.social · last yr.

I can confirm the PBS Passport is a very good deal for $5/month or $2.50/month if you do yearly. Thousands of hours of top notch content. NOVA is great. The new Ken Burns doc on Leonardo da Vinci is excellent. You can sign up at the link below! www.pbs.org/passport/lea...

PBS: Public Broadcasting Service

Watch full episodes of your favorite PBS dramas, find in-depth news analysis and explore documentaries on history, science, art and more!

pbs.org

Anna Bell@annabellreads.bsky.social · last yr.

btw did you know you can subscribe to PBS for only like $5/mo or a $60 one-time for a year donation, and get access to their Passport streaming service? They mail you a little live programming guide and everything, too. The 40-something seasons of NOVA alone are worth it.

Mikala Egeblad@megeblad.bsky.social · last yr.

As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis. 🔗 www.nature.com/articles/s41... @jhu-bdps.bsky.social @nature.com

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

nature.com

Jose M. Adrover@adrover.bsky.social · last yr.

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

nature.com

Ivan Zanoni@lozanzi.bsky.social · last yr.

#WeekendRead! #BeyondNETosis! @caroleparentlab.bsky.social @sbarya.bsky.social &co show @natcellbio.nature.com that neutrophils can secrete nuclear-derived exosomes containing LTB4 & DNA which direct migration but at also favor inflammation resolution via neutrophil retrotransmigration!

Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation - Nature Cell Biology

Arya et al. report that migrating neutrophils resolve acute inflammation by releasing exosomes associated with nuclear DNA. This process is distinct from the release of neutrophil extracellular traps,...

go.nature.com

Carl T. Bergstrom@carlbergstrom.com · last yr.

Very smart, high ROI initiative from the Spencer Foundation. Providing bridge funding for canceled NSF grants: 1) directs funds to projects already screened by a top-noch review process. 2) avoids imposing proposal prep costs on researchers. 3) ameliorates the disruption from GOP sabotage.

Rapid Response Bridge Funding Program

In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...

spencer.org

Michael Love@mikelove.bsky.social · last yr.

Up until June 2 (Monday) you can apply for scholarship to attend GBCC2025 at Cold Spring Harbor Laboratory. This is the Bioconductor / Galaxy joint conference at the end of June. You should submit a poster abstract to apply for scholarship. Scholarship details below.

Scholarship Tiers: • Tier 1 (registration + travel support up to $700) is limited and highly competitive. Only select this if you cannot attend without travel funding. A brief justification is required. • Tier 2 (registration only) is for applicants who can cover their own travel. You must confirm that travel funding is secured. • Tier 3 will cover the VIRTUAL conference registration only. What Registration Includes (Tiers 1 & 2) • Full access to sessions, workshops, and networking events • Daily meals (breakfast, lunch, dinner) • Welcome reception and banquet • On-campus housing • Free on-site parking
Bioconductor@bioconductor.bsky.social · last yr.

🔔 In case you missed it: NEW scholarship opportunities to attend GBCC2025 are now open! We are thrilled to offer this opportunity to our community and hope to see you there! Apply now: forms.gle/WKoLb5NUR6FV... #GBCC2025 #Bioconductor #UseGalaxy #DataScience

Image advertising GBCC2025 Scholarship to attend the Galaxy & Bioconductor Conference, June 23–26 at Cold Spring Harbor. Apply by June 2.
@danapeer.bsky.social · last yr.

I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature

Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

nature.com

STAT@statnews.com · last yr.

A clinical trial run by the National Cancer Institute seems to confirm that a single dose of the vaccine used to prevent infection with the human papilloma virus is just as effective as two www.statnews.com/2025/04/28/h...

U.S. government researchers present 'phenomenal' new data on HPV vaccines

A new study seems to confirm that a single dose of the vaccine used to prevent HPV infection is just as effective as two — and, therefore, also helps to prevent cancer.

statnews.com