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Andres Bendesky

@bendeskylab.com

Neuroscience – behavior – genetics – evolution Columbia University

133 Posts1179 Follower432 Folgt
Jeff Groh@jeffgroh.bsky.social · last wk.

Avocados come in 2 varieties - A-types start each day female and switch to male midday. B-types do the reverse. In work just published from the last chapter of my PhD, we show this system evolved 40+million yrs ago and is regulated by alleles of 1 transcription factor www.pnas.org/doi/10.1073/...

Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado | PNAS

In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two ...

pnas.org

Adam Auton@adamauton.bsky.social · last wk.

23andMe is hiring for 2 amazing roles! - Scientist, ML for Health Risk Prediction: build next-gen health prediction tools integrating genetics. - Scientist, Population Genetics: build state-of-the-art algorithms for genetic relationship & ancestry inference. Links below!

Clément Lafon Placette@plantreproevo.bsky.social · 2w ago

What a systems view can tell us about genomic imprinting in plants! Happy collab with @vojta-ce.bsky.social @omeriltas.bsky.social @apecinka.bsky.social @susnatas.bsky.social @kovacik.bsky.social A. Přibylová and led by Trezalka Budinsky www.biorxiv.org/content/10.6...

Imprinted regulatory networks reveal the molecular cross-talk between paternal and maternal genomes in the endosperm of Arabidopsis arenosa

Imprinted genes do not act alone to shape seed development, but as a complex network - just like any other gene. Yet, the molecular context in which they are embedded, i.e. their gene network, remains...

biorxiv.org

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Heng Li@lh3lh3.bsky.social · 2mo ago

Minibwa is a hybrid of bwa-mem and minimap2 and the successor of bwa-mem for short-read mapping. ~4X/2.5X as fast as bwa-mem/bwa-mem2 for WGS reads at comparable accuracy. Native support of directional bisulfite-seq. Applicable to long reads. Preprint at arxiv.org/abs/2606.15357

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Margarida Cardoso Moreira@margaridamcm.bsky.social · 2mo ago

Beautiful work on the evolution of sensory perception. Existing neuronal lineages are often recoded throughout evolution by the expression of novel olfactory receptor genes. The Arguello lab reconstructed all the steps in this sensory neuron recoding. A must-read!

@tomtom-auer.bsky.social · 2mo ago

How do duplicated receptor genes "find a home" in olfactory circuits? Great study by the Arguello lab shows the re-coding of olfactory channels across species. Neat combination of phylogenetic reconstruction, sc-transcriptomics and more. Check out the pre-print: www.biorxiv.org/content/10.6...

Tris Dodge@tododge.bsky.social · 2mo ago

Excited to share new work on two sex-linked pigment traits in Xiphophorus! This project was led by undergrad @lagiven.bsky.social, who’s worked with me for the last 3(!) years. www.biorxiv.org/content/10.6...

Two melanic pigment patterns are associated with a sex chromosome-linked oncogene in the mountain swordtail Xiphophorus nezahualcoyotl

Sex-linked traits are widespread, but their genetic architecture has been challenging to characterize, due in part to the repetitive and structurally complex nature of sex chromosomes. In swordtails a...

biorxiv.org

Molly Przeworski@mollyprz.bsky.social · 2mo ago

Now published: journals.plos.org/plosbiology/...

What sets the mutation rate of a cell type in an animal species?

Mutation rates per generation are strikingly similar across germlines of animals and across at least one somatic cell type, suggesting a key role for natural selection in shaping mutation rates. This ...

journals.plos.org

Molly Przeworski@mollyprz.bsky.social · 8mo ago

Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n

Tessa Montague@tessamontague.bsky.social · 2mo ago

Do you know an outstanding aquarist? We're hiring a Senior Aquarist to help run our cephalopod facility at Columbia University. Our team maintains a colony of 250+ cuttlefish, develops new husbandry techniques (inc transgenics) & studies cuttlefish camouflage and social behavior. 1/3 [Pls repost!]

Mayor Zohran Kwame Mamdani@mayor.nyc.gov · 2mo ago

Today, I signed an Executive Order temporarily repealing bedtimes in the City of New York so that kids of all ages can watch our team in the NBA Finals. As Mayor, you’re forced to make many difficult decisions. This was not one of them. Go Knicks.

Pauli Group (posts by Andi Pauli)@pauligroup.bsky.social · 3mo ago

New insights into #fertilization from the @pauligroup.bsky.social & Ikawa labs! In a tour-de-force study, we discovered ✨ SPARK ✨, a conserved sperm fertilization complex that couples sperm-egg binding to membrane fusion. Read on 🧵👇 and check out our preprint for more details! tinyurl.com/34cm4xat

tinyurl.com

Victoria Deneke@vdeneke.bsky.social · 3mo ago

How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇

Molly Przeworski@mollyprz.bsky.social · 3mo ago

Happy to highlight new findings by Vanesa Getseva and Lin Poyraz about the sources of variation in germline mutation rates among humans: www.biorxiv.org/content/10.6... Joint work with Anastasia Stolyarova and @ipsitaagarwal.bsky.social. 1/n

A sibling study of variation in parental mutation rates

People are born with variable numbers of de novo germline mutations (DNMs), depending primarily on the ages of their parents. To explore additional causes, we developed an approach to call DNMs from nucleotide differences between siblings in genomic regions inherited identical by descent from both parents. Applying it to whole genome sequences from 28,985 sibling pairs of diverse genetic ancestries present in the UK Biobank and All of Us datasets, as well as 2,330 trios, we identified >800K autosomal DNMs and characterized mutation phenotypes in 27,645 sets of parents. We found subtle shifts in the mutation spectrum but no differences in total DNM rates among genetic ancestry groups, or between smokers and non-smokers. Testing for associations between parental mutation phenotypes and their burden of loss-of-function and deleterious missense variants in a set of 180 DNA repair and maintenance genes, we discovered that disruptions in REV1 and LIG1 increase germline mutation rates, and thus that rare mutator alleles segregate in population cohorts. ### Competing Interest Statement The authors have declared no competing interest. NIH, R35 GM083098

biorxiv.org

Drew Schreiner@schreinerdrew.bsky.social · 3mo ago

Where, exactly, does learning happen in the brain? Out today in @nature.com, we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster - but at a cost. Read on👇 #neuroskyence 🧪 #prattle 💬 #bioacoustics Shareable link: rdcu.be/fiyrS

A synaptic locus of song learning - Nature

Combining a computational framework and optogenetic and chemogenetic manipulations within and downstream of the cortico-basal ganglia circuit identifies the specific cortico-basal ganglia synapse...

nature.com